Systemic Reactions to Topically Applied Drugs

Pascher, Frances

doi:10.1111/j.1365-4362.1978.tb05977.x

Cited by 32 publications

(24 citation statements)

References 39 publications

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“…The solution used in this study comprised 4.5 g phenol, 10 g resorcinol, 0.3 g basic fuchsin, 5 ml acetone, 9.4 ml of 80% ethanol, and 85.6 ml of distilled water, of which the components of this solution have antifungal (carbol-fuchsin), antibacterial (ethanol and resorcinol), and acidic (acetone) eVects. Although some studies have suggested the possibility that some ingredients are toxic (e.g., phenol, acetone, and resorcinol), they comprise less than 5-10% of the total solution and castellani solution has been used only topically [18]. Moreover, in a recent animal study, topical application of castellani solution to the round window membrane in the middle ear cavity did not have any eVect on the outer hair cell function [19].…”

Section: Discussionmentioning

confidence: 96%

Clinical characteristics of granular myringitis treated with castellani solution

Kim

2011

Eur Arch Otorhinolaryngol

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Aim of the study is to observe clinical manifestations of granular myringitis (GM) treated with castellani solution. Twenty-four patients (18 women and 6 men; mean age, 49.7 years; range, 9-77 years) diagnosed with GM and treated with castellani solution were enrolled retrospectively. Topical treatment using castellani solution with or without curettage of a granular lesion and serial otoendoscopy-aided photographic documentation of the tympanic membrane were performed. Outpatient follow-up period ranged from 3 to 72 months and the mean follow-up period was 14.4 months. GM was classified into marginal/non-marginal type and ulcerative/polypoid subtype using a new scale. According to the scale used in this study, the marginal and ulcerative GM was the predominant type of GM lesion. Bacterial cultures of ear discharges from 19 patients revealed Staphylococcus, Corynebacterium and Providencia stuartii in 12, 5, and 1 patient, respectively and no growth of bacteria in one patient. Of 24 patients, 23 showed complete resolution of GM after treatment with castellani solution. However, one patient had a persistent, small, dry, deepithelialized lesion and eight others required more than 3 months for complete recovery owing to a persistent residual lesion. There was recurrence in two patients but the lesion resolved after additional castellani treatment. Topical application of castellani solution is a simple and effective treatment for GM. This study suggests a potential of castellani solution for treatment of GM with a serial photographic documentation and novel classification scale for description of lesions. A sufficiently long follow-up period is essential to confirm a complete recovery of GM.

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Section: Discussionmentioning

confidence: 96%

Clinical characteristics of granular myringitis treated with castellani solution

Kim

2011

Eur Arch Otorhinolaryngol

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“…Phenol (hydroxybenzene, carbolic acid) has been used as an antiseptic for the sterilization of ulcers and burns. 55 Phenol is a potent CNS and respiratory system stimulant as well as a protoplasmic poison and can cause renal failure by direct damage to the kidney. The mechanism for this is the uncoupling of oxidative phosphorylation.…”

Section: Acids and Other Chemicals That Burn Skinmentioning

confidence: 99%

Systemic toxicity from skin exposures (or what happens when you do not decontaminate)

McDougal¹,

Council²,

Powers³

2007

J. Chem. Health Saf.

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Decontamination of the skin is a process that is incompletely understood and as a result, some decontamination procedures can make penetration of a chemical through the skin worse. Therefore, it is necessary to decontaminate the skin on a rational basis, rather than indiscriminately. Systemic toxicity from skin exposures is the combined result of two chemical characteristics -penetration of the chemical through the skin and toxic potency of the chemical. The range of penetrability and toxic potency for common industrial chemicals varies over several orders of magnitude. Even an extremely toxic chemical that does not penetrate the skin readily may not need decontamination after exposure. The purpose of this review is to provide information about systemic toxicity from skin exposures and how chemical permeability and toxicity are determined, so that an individual may evaluate the necessity for decontamination of chemicals used in his/ her specific workplace.

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“…A 40% peeling resorcinol paste applied daily for 3 weeks produced dizziness, pallor, cold sweat, tremors, and collapse on final application. [318] Resorcinol has an anti-thyroid activity. Hence, continuous application can cause myxedema.…”

Section: Intralesional Steroidsmentioning

confidence: 99%

Complications of medium depth and deep chemical peels

Nikalji

Godse

Sakhiya³

et al. 2012

J Cutan Aesthet Surg

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Superficial and medium depth peels are dynamic tools when used as part of office procedures for treatment of acne, pigmentation disorders, and photo-aging. Results and complications are generally related to the depth of wounding, with deeper peels providing more marked results and higher incidence of complications. Complications are also more likely with darker skin types, certain peeling agents, and sun exposure. They can range from minor irritations, uneven pigmentation to permanent scarring. In very rare cases, complications can be life-threatening.

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Systemic Reactions to Topically Applied Drugs

Cited by 32 publications

References 39 publications

Clinical characteristics of granular myringitis treated with castellani solution

Clinical characteristics of granular myringitis treated with castellani solution

Systemic toxicity from skin exposures (or what happens when you do not decontaminate)

Complications of medium depth and deep chemical peels

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