2011
DOI: 10.2500/aap.2011.32.3446
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Systemic reactions to subcutaneous allergen immunotherapy and the response to epinephrine

Abstract: The use of epinephrine for anaphylaxis to subcutaneous allergen immunotherapy (SCIT) is the standard of care, but its use for mild systemic reactions (SRs) is somewhat controversial. The objective of this study is to determine the rate of SR to SCIT, the symptoms reported, and the response to intramuscular (i.m.) epinephrine over a 1 year period. This retrospective study was designed to evaluate SRs to SCIT to any combination of approximately 20 allergens (pollens, animal emanations, molds, and Hymenoptera) in… Show more

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Cited by 38 publications
(20 citation statements)
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“…To the best of our knowledge, this is the largest study reporting the safety outcome of a self‐administered SCIT protocol for a patient cohort consisting of tens of thousands of individuals. The UAS SR rates are significantly lower than those promulgated for traditional in‐office IT protocols ( p < 0.0001) . No grade V anaphylactic reactions occurred in over 2 million home‐administered injections.…”
Section: Discussionmentioning
confidence: 87%
“…To the best of our knowledge, this is the largest study reporting the safety outcome of a self‐administered SCIT protocol for a patient cohort consisting of tens of thousands of individuals. The UAS SR rates are significantly lower than those promulgated for traditional in‐office IT protocols ( p < 0.0001) . No grade V anaphylactic reactions occurred in over 2 million home‐administered injections.…”
Section: Discussionmentioning
confidence: 87%
“…However, in most countries of the world, AIT remains a niche treatment secondary to symptomatic drugs due to its cost, the long duration of treatment, poor compliance by patients and, in particular, concerns regarding safety and individual efficacy. There have been many observational studies on large samples [17,18,19]that recognize and deal with adverse reactions during treatment and evaluate safety in the long term after AIT [20]. There are few reports, however, on the development of methods for identifying AIT-responsive and nonresponsive endotypes and phenotypes to guide patient selection.…”
Section: Discussionmentioning
confidence: 99%
“…However, in many immunisation clinics, infusion clinics, and allergen immunotherapy clinics, nurses are preauthorised to do this. 30 In community settings, adrenaline is often self injected through an autoinjector by the patient or injected by the parent, teacher, or other person responsible for the child. Delay in administration is associated with greater likelihood of biphasic and protracted anaphylaxis, and of death 23 24 ; in a UK series, only 14% of the patients who died from anaphylaxis received adrenaline before respiratory or cardiac arrest.…”
Section: Skin Subcutaneous Tissue and Mucosamentioning
confidence: 99%