BackgroundPlacement of a Blalock-Taussig (BT) shunt is frequently performed for palliation of
cyanotic congenital heart disease (CCHD).ObjectivesInhalational anesthetics, when used in adult heart surgery, offer advantages of
myocardial protection and decrease in use of inotropes, duration of ventilation, ICU and
hospital length of stay (LOS).There is little literature, however, in the comparative
use of inhalational and narcotic anesthesia in CCHD.Patients and MethodsFollowing Institutional Ethical Review Board approval and parental consent, 35 patients
presenting for BT shunt were prospectively randomized to receive either a desflurane
anesthetic or a narcotic anesthetic. Institutional practice for all patients undergoing
BT shunt is to undergo cardiopulmonary bypass (CPB) following median sternotomy.
Induction was accomplished with 5-7% sevoflurane in 100% oxygen, 2ug/kg fentanyl,
0.05mg/kg midazolam and 0.1mg/kg vecuronium. After intubation, patients in the narcotic
group (n=16) received an additional 5-10ug/kg fentanyl, 0.1mg/kg midazolam, 100% oxygen
and vecuronium. Patients in the inhalational group (n=19) received desflurane, 0.6-1
MAC, 100% oxygen, 0.05mg/kg midazolam, IV paracetamol 15mg/kg and vecuronium. At the end
of surgery, patients were transferred to the ICU and received IV paracetamol and
midazolam. Ventilation was weaned when the patient was hemodynamically stable.
Demographics, baseline, intra and post-op heart rates, duration of inotrope use, ICU and
hospital LOS, pre and post-op creatinine and serious adverse events (SAE) were recorded.
Data were analyzed using Student, paired t, Mann-Whitney U and Chi square/Fisher exact
tests, P < 0.05 significant.ResultsDemographic data were similar, except for a modestly higher pre-op heart rate in the
group receiving opioid anesthesia. Patients receiving desflurane had a significantly
shorter duration of mechanical ventilation and length of ICU and hospital stay. Inotrope
use was similar in both groups. The group receiving opioid anesthesia had an increase in
creatinine post operatively which was not observed in the desflurane group. There was no
difference in incidence of significant adverse events in either group.ConclusionsUse of inhalational anesthesia has increased in adult cardiac surgery and has proved to
reduce duration of elective ventilation, decrease ICU and hospital LOS, and mortality.
Inhalational anesthetics are less well-studied in CCHD. In the current study, desflurane
was chosen because of its low solubility, decreased recovery time and lack of metabolism
or organ system toxicities. Although it is a popular belief that desflurane is
associated with tachycardia and airway irritation, findings of the current study are
consistent with those of the previous works demonstrating a lack of these side effects
below 1 MAC3. No hemodynamic instability was encountered and there was no evidence that
desflurane exerted a negative inotropic effect. Markers of cardio protection were not
examined, although desflurane may have had a renal protective effe...