Systemic Protection by Antioxidants Against Uvl-Induced Erythema

Rios, Gioconda. De; Chan, Joel; Black, Homer S.; Rudolph, Andrew H.; Knox, John M.

doi:10.1111/1523-1747.ep12258527

Cited by 51 publications

(18 citation statements)

References 23 publications

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“…Photoprotection by endogenous compounds provided from components in the diet via endogenous delivery to the skin becomes a focus of lifelong major interest. Knowledge on systemic photoprotection is in its early stages (108), although pioneering studies stem from about 30 years ago (41,54,100). There is evidence from in vitro, animal, and human studies demonstrating actions of dietary constituents as endogenous photoprotectants (148).…”

Section: Introductionmentioning

confidence: 99%

Nutritional Protection Against Skin Damage From Sunlight

2004

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▪ Abstract The concept of systemic photoprotection by dietary means is gaining momentum. Skin is continuously exposed to ultraviolet (UV) radiation, the major cause of skin disorders such as sunburn, photodamage, and nonmelanoma skin cancer. Most of the erythemal annual UV dose is encountered under nonvacation conditions, when no sunscreen is applied. In the absence of topically added compounds, skin protection depends solely on endogenous defense. Micronutrients can act as UV absorbers, as antioxidants, or can modulate signaling pathways elicited upon UV exposure. UV-induced erythema is a suitable parameter to assess photoprotection. Dietary protection is provided by carotenoids, tocopherols, ascorbate, flavonoids, or n-3 fatty acids, contributing to maintenance resistance as part of lifelong protection.

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Section: Introductionmentioning

confidence: 99%

Nutritional Protection Against Skin Damage From Sunlight

2004

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“…Protection from inflammation‐edema by Pycnogenol® is consistent with other studies reporting protection from capillary damage and edema (8). The mechanism is unclear, but is consistent with an antioxidant action, because prooxidant states may contribute to UV‐induced inflammation, and other antioxidant compounds have been shown to protect from such acute UV‐induced damage (24,25).…”

Section: Discussionmentioning

confidence: 93%

Protection from Inflammation, Immunosuppression and Carcinogenesis Induced by UV Radiation in Mice by Topical Pycnogenol®^¶

Sime

Reeve

2004

Photochem & Photobiology

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Pycnogenol® is a standardized extract of the bark of the French maritime pine, Pinus pinaster Ait., that has multiple biological effects, including antioxidant, anti‐inflammatory and anticarcinogenic properties. This study describes the effect of topical application of lotions containing Pycnogenol® to Skh:hr hairless mice undergoing minimally inflammatory daily exposures to solar‐simulated UV radiation (SSUV). We report that concentrations of Pycnogenol® of 0.05–0.2% applied to the irradiated dorsal skin immediately after exposure resulted in dose‐dependent reduction of the inflammatory sunburn reaction, measured as its edema component. When mice received three consecutive daily exposures of minimally edematous SSUV, their ability to raise a contact hypersensitivity (CHS) reaction was suppressed by 54%. Pycnogenol® lotions applied postirradiation reduced this immunosuppression to 22% (0.05% Pycnogenol®) and 13% (0.1 % Pycnogenol®). Furthermore, when CHS was suppressed by 71% with exogenous treatment with cis‐urocanic acid, the putative epidermal mediator of photoimmunosuppression, 0.2% Pycnogenol® lotion reduced the immunosuppression to 18%. Chronic exposure to SSUW on 5 days/week for 10 weeks induced skin tumors from 11 weeks in both control mice and in mice receiving daily applications of 0.05% Pycnogenol®, but tumor appearance was significantly delayed until 20 weeks in mice receiving 0.2% Pycnogenol®. Furthermore, whereas 100% of control mice had at least one tumor by 30 weeks, and mice treated with 0.05% Pycnogenol® by 33 weeks, the maximum tumor prevalence in mice treated with 0.2% Pycnogenol® was significantly reduced to 85%, with some mice remaining tumor free. Average tumor multiplicity was also significantly reduced by 0.2% Pycnogenol®, from 5.2 in control mice to 3.5 at 35 weeks. Thus, topical Pycnogenol® offered significant and dose‐dependent protection from SSUV induced acute inflammation, immunosuppression and carcinogenesis, when applied to the skin after daily irradiation. Pycnogenol®, therefore, in addition to its recognized health benefits in other organs, appears to have potential in providing photoprotection for humans in a complementary role with sunscreens, having demonstrable activity when applied to the skin after, rather than before, UV exposure.

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“…Many studies have achieved protective antioxidant effects of carotenoids and vitamins together against acute and chronic manifestations of skin photo damage [27][28][29].…”

Section: Normalized Concentration Of Beta-carotenementioning

confidence: 99%

Resonance Raman spectroscopy as an effective tool for the determination of antioxidative stability of cosmetic formulations

Darvin

Sterry

Lademann

2009

Journal of Biophotonics

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Carotenoids beta-carotene, lutein, lycopene and others are well-known powerful antioxidants acting as an effective neutralizer of free radicals produced in the human organism as a result of the influence of stress factors, such as UV irradiation. The protective effect of antioxidants is used in cosmetic products to increase the skin protection against the destructive action of free radicals and for the stabilization of formulations against oxidation. In the skin, the different antioxidant substances form protection chains to avoid their destruction by the interaction with the free radicals. Similar effects have to be expected also in topically applied formulations. In the present study the influence of different mixtures of antioxidants (beta-carotene, vitamins C and E) on the stability of antioxidants in formulations used for skin treatment was investigated. The measurements were carried out by using non-invasive resonance Raman spectroscopy for the detection of the carotenoid concentration in the cosmetic formulations.

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Systemic Protection by Antioxidants Against Uvl-Induced Erythema

Cited by 51 publications

References 23 publications

Nutritional Protection Against Skin Damage From Sunlight

Nutritional Protection Against Skin Damage From Sunlight

Protection from Inflammation, Immunosuppression and Carcinogenesis Induced by UV Radiation in Mice by Topical Pycnogenol®^¶

Resonance Raman spectroscopy as an effective tool for the determination of antioxidative stability of cosmetic formulations

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Systemic Protection by Antioxidants Against Uvl-Induced Erythema

Cited by 51 publications

References 23 publications

Nutritional Protection Against Skin Damage From Sunlight

Nutritional Protection Against Skin Damage From Sunlight

Protection from Inflammation, Immunosuppression and Carcinogenesis Induced by UV Radiation in Mice by Topical Pycnogenol®¶

Resonance Raman spectroscopy as an effective tool for the determination of antioxidative stability of cosmetic formulations

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Protection from Inflammation, Immunosuppression and Carcinogenesis Induced by UV Radiation in Mice by Topical Pycnogenol®^¶