Systemic polyarteritis nodosa as the initial manifestation of a gastric adenocarcinoma

Poveda, Francisco; González-García, Juan; Picazo, M.L.; Giménez, America; Camacho, J Olmedo; Barbado, F J; Vázquez-Rodríguez, Juan José

doi:10.1111/j.1365-2796.1994.tb00862.x

Cited by 20 publications

(8 citation statements)

References 7 publications

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“…The use of the Watts' algorithm in our patient resulted in a diagnosis of MPA. To the best of our knowledge, the concurrent presence of PAN and gastric cancer has been reported in only two patients [12,13], but no case of AAV associated with gastric cancer has been reported to date. Gastric cancer is thought to be rarely associated with any type of vasculitis.…”

Section: Discussionmentioning

confidence: 78%

Resolution of anti-neutrophil cytoplasmic antibody-associated vasculitis after resection of gastric cancer

Hosoya¹,

Minota²,

Lefor³

et al. 2009

Mod Rheumatol

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We report a case of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis in a 62-year-old patient with gastric cancer. The myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) level was threefold above normal preoperatively. Vasculitis was seen on renal biopsy. Gastric resection revealed well-differentiated adenocarcinoma and vasculitis. The MPO-ANCA level returned to normal post-operatively. Although ANCA-associated vasculitis occasionally accompanies malignant tumors, this is the first documented case of concurrent gastric cancer-associated and ANCA-associated vasculitis, with post-operative resolution of the vasculitis.

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Section: Discussionmentioning

confidence: 78%

Resolution of anti-neutrophil cytoplasmic antibody-associated vasculitis after resection of gastric cancer

Hosoya¹,

Minota²,

Lefor³

et al. 2009

Mod Rheumatol

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“…; cutaneous leukocytoclastic vasculitis is the most frequent type noted. To date, only 3 cases of PN-associated solid cancer have been reported [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

A case of polyarteritis nodosa complicated by rectal cancer

Oku

Okamoto²,

Sakai

et al. 2010

Clin J Gastroenterol

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Solid cancers are rarely complicated by the occurrence of polyarteritis nodosa (PN), and most cases diagnosed as PN are, in fact, cases of paraneoplastic vasculitis. Paraneoplastic vasculitis is usually resolved after tumor removal. We present a rare case of a 69-year-old man with PN complicated by rectal cancer, without the occurrence of paraneoplastic vasculitis. Microscopic examination of the resected cancer lesion revealed inflammation of some arteries and neutrophil and lymphocyte infiltration, fibrin deposition, stenosis, and vasodilatation of capillaries caused by congestion in the submucosal layer. It was unclear how these findings exerted influence on the rectal cancer. Although the symptoms of PN did not improve after the patient's tumor was removed surgically, the symptoms improved rapidly after oral treatment with prednisolone and cyclophosphamide.

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“…The cause of the atrophy was not apparent with neurologic diagnostic modalities, and therefore the case was assumed to be due to a paraneoplastic manifestation [9]. There is also a case report of systemic polyarteritis nodosa leading to the discovery of an asymptomatic, surgically curable gastric adenocarcinoma, and a diagnosis of paraneoplastic systemic angiitis was given [10].…”

Section: Discussionmentioning

confidence: 99%

A case study of paraneoplastic cauda equina syndrome caused by a gastric adenocarcinoma

Hunt¹,

Zack-Williams²,

Hargreaves³

et al. 2016

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. IJCRI publishes ABSTRACTIntroduction: Cauda equina syndrome results from dysfunction of multiple sacral and lumbar nerve roots in the lumbar vertebral canal, leading to impairment of bladder, bowel, or sexual function, and perianal or "saddle" numbness. The most common cause of cauda equina syndrome is disc herniation resulting in compression at L4/5 and L5/S1. However, we will discuss the case of cauda equine syndrome with a paraneoplastic cause. There are only a handful of cases in literature of paraneoplastic cauda equine syndrome, and none specifically as a result of gastric adenocarcinoma. Paraneoplastic neurological syndromes (of which paraneoplastic cauda equine syndrome is one) are described as remote effects of cancer on the neurological system. They are rare, affecting less than 1/10,000 patients with cancer. In this case, the cauda equina was the target for an autoimmune response directed against antigens common to both the cancer and the nervous system. Case Report: A 71-year-old female was admitted with a two-month history of lumbar back pain, radiating down her thigh, progressive weakness of both legs, numbness of the sacral area, urinary incontinence and 6.4 kilogram unintentional weight loss within 2 months. Abdominal radiograph, breast examination, lumbar puncture, and autoantibodies screens were all negative. Abdominal and pelvic CT, spinal MRI, radioisotope scan and abdominal USS still did not demonstrate any malignant process. One month after admission, the patient deteriorated with sudden abdominal peritonism, tachycardia and hypothermia. An urgent CT was performed, which demonstrated a gastric perforation.A laparotomy was undertaken which demonstrated a 4-cm gastric perforation. Biopsies were taken and the histology subsequently demonstrated a high grade, poorly differentiated adenocarcinoma. From this diagnosis, it was ascertained that she had been suffering from secondary paraneoplastic neuropathy, caused by the gastric adenocarcinoma in the body of the stomach. This specific case has not been reported in literature within the last 10 years. Conclusion:In conclusion, an unusual presentation of acute and progressive neuropathy without obvious spinal/ cranial aetiology and associated cachexia should prompt thorough investigation to exclude a neoplastic process, as paraneoplastic syndromes may be the first sign of malignancy.

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Systemic polyarteritis nodosa as the initial manifestation of a gastric adenocarcinoma

Cited by 20 publications

References 7 publications

Resolution of anti-neutrophil cytoplasmic antibody-associated vasculitis after resection of gastric cancer

Resolution of anti-neutrophil cytoplasmic antibody-associated vasculitis after resection of gastric cancer

A case of polyarteritis nodosa complicated by rectal cancer

A case study of paraneoplastic cauda equina syndrome caused by a gastric adenocarcinoma

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