Systemic pharmacology reveal the mechanism by which the Qiangjin Zhuanggu Qufeng mixture inhibits LPS-induced pyroptosis of rat nucleus pulposus cells

Wang, Dong; Zhang, Liangping; He, Du; Zhang, Yujun; Bao, Jianhang; Gao, Wenshuo; Cheng, Wei; Zhu, Caihong; Jin, Hongting; Zhang, Wei; Zhu, Hongrui; Pan, Hao

doi:10.1016/j.phymed.2023.154998

Cited by 3 publications

(1 citation statement)

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“…Therefore, the inhibition of Propionibacterium acnes could potentially offer therapeutic benefits in the management of intervertebral disc degeneration. Moreover, traditional Chinese medicines have been demonstrated to play a prominent role in maintaining homeostasis of the inner nucleus pulposus and inhibiting disc degeneration [149][150][151][152]. Additionally, owing to their resemblance to natural extracellular matrix and exceptional biocompatibility, hydrogels exhibit immense potential as controlled drug release vectors for the treatment of disc degeneration.…”

Section: Future Directions and Conclusionmentioning

confidence: 99%

Achilles’ Heel—The Significance of Maintaining Microenvironmental Homeostasis in the Nucleus Pulposus for Intervertebral Discs

Luo,

Wei,

Zhang

et al. 2023

IJMS

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The dysregulation of intracellular and extracellular environments as well as the aberrant expression of ion channels on the cell membrane are intricately linked to a diverse array of degenerative disorders, including intervertebral disc degeneration. This condition is a significant contributor to low back pain, which poses a substantial burden on both personal quality of life and societal economics. Changes in the number and function of ion channels can disrupt the water and ion balance both inside and outside cells, thereby impacting the physiological functions of tissues and organs. Therefore, maintaining ion homeostasis and stable expression of ion channels within the cellular microenvironment may prove beneficial in the treatment of disc degeneration. Aquaporin (AQP), calcium ion channels, and acid-sensitive ion channels (ASIC) play crucial roles in regulating water, calcium ions, and hydrogen ions levels. These channels have significant effects on physiological and pathological processes such as cellular aging, inflammatory response, stromal decomposition, endoplasmic reticulum stress, and accumulation of cell metabolites. Additionally, Piezo 1, transient receptor potential vanilloid type 4 (TRPV4), tension response enhancer binding protein (TonEBP), potassium ions, zinc ions, and tungsten all play a role in the process of intervertebral disc degeneration. This review endeavors to elucidate alterations in the microenvironment of the nucleus pulposus during intervertebral disc degeneration (IVDD), with a view to offer novel insights and approaches for exploring therapeutic interventions against disc degeneration.

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Section: Future Directions and Conclusionmentioning

confidence: 99%