Systemic oxidative stress in children and teenagers with Down syndrome

Abstract

The results revealed a systemic pro-oxidant status in DS individuals, evidenced by the increased activity of some important antioxidant enzymes, together with decreased GSH levels in whole blood and elevated UA levels in plasma, probably as an antioxidant compensation related to the redox imbalance in DS individuals.

Association Between Down Syndrome and In-Hospital Death Among Children Undergoing Surgery for Congenital Heart Disease

“…Blood levels of the antioxidant enzymes superoxide dismutase, catalase, and glutathione reductase have recently been shown to be 47.2%, 24.7%, and 49.6% greater in healthy children and teenagers with DS as compared with healthy age-matched chromosomally normal controls. 31 There are risk factors that would be expected to be associated with less favorable outcomes for children with DS who undergo cardiac surgical repairs. The latter include their increased likelihood of having cervical spine instability and airway abnormalities, including subglottic stenosis, laryngomalacia, tracheomalacia, tracheal bronchus, and bronchomalacia.…”

Persistence of the benefit of an antioxidant therapy in children and teenagers with Down syndrome

“…In two recent accompanied papers by Garlet et al (2013) and Parisotto et al (2014), both from our laboratory, biomarkers of OS were evaluated in blood samples collected from children and teenagers with DS, using the same protocol and experimental design of the present study. However, now the biomarkers of OS were evaluated in the blood of DS patients (n = 21) before (t 0 ) and after a daily antioxidant intervention (vitamin E 400 mg, C 500 mg, E-TABS 1 and Energil C 1 , respectively) during 6 months (t 1 ), as well as after an interruption of the supplementation (also after 6 months) (t 2 ) and after a new supplementation of further 6 months (t 3 ).…”

“…There is consequently a gene dosage effect in DS leading to $50% greater levels of SOD-1 and elevated endogenous production of hydrogen peroxide (H 2 O 2 ), and potentially of hydroxyl radical ( OH) (Garlet et al, 2013;Lott, 2012), which is the most reactive and deleterious ROS inducing damage in proteins, lipids and DNA (Halliwell & Gutteridge, 2007).…”

Detection and Quantification of Free Radicals in Peroxisomal Disorders: A Comparative Study with Oxidative Stress Parameters

“…On the other hand, Petrillo et al reported similar SOD activity in peroxisomal disorder patients and control group [23], while Baarine et al, reported higher SOD in patients with peroxisomal disorders [10]. Over expression of SOD was also reported in oxidative stress conditions associated with neural disorders [30]. This confliction between all these different studies may be underscored by the fact that levels of SOD in peroxisomal disorders depend on the degree of disease severity, activity of the disease and exhaustion or depletion of the enzyme.…”