Systemic oxidative stress, as measured by urinary allantoin and F2-isoprostanes, is not increased in Down syndrome

Tolun, Adviye A.; Scarbrough, Peter M.; Zhang, Haoyue; McKillop, Jane-Ann; Wang, Frances; Kishnani, Priya S.; Millington, David S.; Young, Sarah P.; Il’yasova, Dora

doi:10.1016/j.annepidem.2012.09.005

Cited by 16 publications

(11 citation statements)

References 26 publications

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“…For example, children with sickle cell disease have hyperactive metabolism, which is associated with greater F 2 -IsoP levels [ 34 , 35 ]. In contrast, patients with Down syndrome have lower metabolic rate and are prone to obesity [ 36 ], which corresponds to our findings of a trend of lower urinary F 2 -IsoP levels in Down syndrome patients [ 37 ]. On the other hand, in a relatively homogenous ethnic population of Danish monozygotic and dizygotic twins (with similar genetic background), the heritability of urinary F 2 -IsoP levels was low (~22%) [ 38 ].…”

Section: Discussionsupporting

confidence: 89%

African Ancestry Gradient Is Associated with Lower Systemic F₂‐Isoprostane Levels

Annor

Goodman

Thyagarajan

et al. 2017

Oxidative Medicine and Cellular Longevity

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Context. Low levels of systemic F2-isoprostanes (F2-IsoP) increase the risk of diabetes and weight gain and were found in African Americans. Low F2-IsoPs could reflect an unfavorable metabolic characteristic, namely, slow mitochondrial metabolism in individuals with African ancestry. Objective. To examine differences in plasma F2-IsoPs in three groups with a priori different proportion of African ancestry: non-Hispanic Whites (NHWs), US-born African Americans (AAs), and West African immigrants (WAI). Design. Cross-sectional study. Setting. Georgia residents recruited from church communities. Participants. 218 males and females 25–74 years of age, who are self-identified as NHW (n = 83), AA (n = 56), or WAI (n = 79). Main Outcome Measure(s). Plasma F2-IsoPs quantified by gas chromatography-mass spectrometry. Results. After adjustment for age, gender, obesity, and other comorbidities, WAI had lower levels of plasma F2-IsoP than AA (beta-coefficient = −9.8, p < 0.001) and AA had lower levels than NHW (beta-coefficient = −30.3, p < 0.001). Similarly, among healthy nonobese participants, F2-IsoP levels were lowest among WAI, followed by AA, and the highest levels were among NHW. Conclusion. Plasma F2-IsoPs are inversely associated with African ancestry gradient. Additional studies are required to test whether optimization of systemic F2-IsoP levels can serve as means to improve race-specific lifestyle and pharmacological intervention targeted to obesity prevention and treatment.

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Section: Discussionsupporting

confidence: 89%

African Ancestry Gradient Is Associated with Lower Systemic F₂‐Isoprostane Levels

Annor

Goodman

Thyagarajan

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…There are several reports concerning the determination of allantoin in human urine [10][11][12][13][14]. Allantoin (5-ureidohydantoine) has recently been considered a promising biomarker of prooxidative processes [12,13] specific only for apes and humans [15].…”

Section: Allantoinmentioning

confidence: 99%

“…It requires the use of sensitive and specific analytical techniques [21]. Allantoin was determined by means of capillary zone electrophoresis (CZE) [27], enzymatic assay and enzyme cycling method [28], capillary electrophoresis with UV detection (CE-UV) [29], high performance liquid chromatography -UV detection (HPLC-UV) [9,30], ultra performance liquid chromatography -tandem mass spectrometry (HPLC/UPLC-MS/MS) [10][11][12][13][14]21], and gas chromatography -mass spectrometry (GC-MS) [20,24,31], and allantoin is detected readily in urine, plasma, and synovial fluid [25].…”

Section: Allantoinmentioning

confidence: 99%

Today’s oxidative stress markers

Czerska¹,

Mikołajewska²,

Zieliński³

et al. 2015

Med Pr

154

103

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Oxidative stress represents a situation where there is an imbalance between the reactive oxygen species (ROS) and the availability and the activity of antioxidants. This balance is disturbed by increased generation of free radicals or decreased antioxidant activity. It is very important to develop methods and find appropriate biomarkers that may be used to assess oxidative stress in vivo. It is significant because appropriate measurement of such stress is necessary in identifying its role in lifestyle-related diseases. Previously used markers of oxidative stress, such as thiobarbituric acid reactive substances (TBARS) or malondialdehyde (MDA), are progressively being supplemented by new ones, such as isoprostanes (IsoPs) and their metabolites or allantoin. This paper is focusing on the presentation of new ones, promising markers of oxidative stress (IsoPs, their metabolites and allantoin), taking into account the advantage of those markers over markers used previously. Med Pr 2015;66(3):393-405Key words: isoprostanes, oxidative stress, oxidative stress markers, allantoin, metabolites of isoprostanes StreszczenieStres oksydacyjny jest stanem braku równowagi między działaniem reaktywnych form tlenu (RFT) a działaniem antyoksydantów. Równowaga ta może być zakłócona w wyniku zwiększonego działania wolnych rodników lub spadku aktywności antyoksydacyjnej. Zaburzenia te mogą występować zarówno na poziomie komórkowym, jak i całego organizmu. Ponieważ stres oksydacyjny może być podłożem wielu zespołów chorobowych, niezwykle istotne jest znalezienie odpowiednich markerów, które mogą być wykorzystane do oceny jego poziomu in vivo. Stosowane od wielu lat markery -ocenę stężenia aldehyd dimalonowy (MDA) i substancji reagujących z kwasem tiobarbiturowym (thiobarbituric acid reactive substances -TBARS) -stopniowo uzupełnia się nowymi, takimi jak alantoina czy izoprostany (IzoP) wraz z ich metabolitami (IzoP-M). W niniejszej pracy skupiono się na zaprezentowaniu nowych, obiecujących markerów stresu oksydacyjnego (alantoina, IzoP, IzoP-M), ukazując korzyści wynikające z ich stosowania i prognozując dalsze kierunki badań nad ich zastosowaniem. Med. Pr. 2015;66(3):393-405 Słowa kluczowe: izoprostany, stres oksydacyjny, markery stresu oksydacyjnego, alantoina, metabolity izoprostanów Corresponding author / Autorka do korespondencji: Marta Czerska,

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“…In addition, accumulation of 8-hydroxy-2-deoxyguanosine (8OHdG), oxidized proteins and nitrotyrosine, was observed in the cytoplasm of DS [79]. At the systemic level, the amount of isoprostane 8,12-iso-iPF2α (iPF2α), a specific marker of lipid peroxidation, is elevated in urine samples from adults with DS [80]. In addition, levels of AGEs, dityrosine, H 2 O 2 , and nitrite/nitrate are significantly higher in urine samples of DS compared with age-matched controls [81].…”

Section: Oxidative Stress: a Common Pathological Feature Of Down Syndmentioning

confidence: 99%

Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain

Butterfield

Domenico

Swomley

et al. 2014

Biochemical Journal

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Accumulation of oxidative damage is a common feature of neurodegeneration that together with mitochondrial dysfunction point to the fact that reactive oxygen species are major contributors to loss of neuronal homeostasis and cell death. Among several targets of oxidative stress, free radical-mediated damage to proteins is particularly important in aging and age-related neurodegenerative diseases. In the majority of cases, oxidative stress mediated post-translational modifications cause non-reversible modifications of protein structure that consistently lead to impaired function. Redox proteomics methods are powerful tools to unravel the complexity of neurodegeneration, by identifying brain proteins with oxidative post-translational modifications that are detrimental for protein function. The present review discusses the current literature showing evidence of impaired pathways linked to oxidative stress possibly involved in the neurodegenerative process leading to the development of Alzheimer-like dementia. In particular, we focus attention on dysregulated pathways that underlie neurodegeneration in both aging adults with Down syndrome (DS) and AD. Since AD pathology is age-dependent in DS and shows similarities with AD, identification of common oxidized proteins by redox proteomics in both DS and AD can improve our understanding of the overlapping mechanisms that lead from normal aging to development of AD. The most relevant proteomics findings highlight that disturbance of protein homeostasis and energy production are central mechanisms of neurodegeneration and overlap in aging DS and AD. Protein oxidation impacts crucial intracellular functions and may be considered a “leitmotif” of degenerating neurons. Therapeutic strategies aimed at preventing/reducing multiple components of processes leading to accumulation of oxidative damage will be critical in future studies.

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Systemic oxidative stress, as measured by urinary allantoin and F2-isoprostanes, is not increased in Down syndrome

Cited by 16 publications

References 26 publications

African Ancestry Gradient Is Associated with Lower Systemic F₂‐Isoprostane Levels

African Ancestry Gradient Is Associated with Lower Systemic F₂‐Isoprostane Levels

Today’s oxidative stress markers

Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain

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Systemic oxidative stress, as measured by urinary allantoin and F2-isoprostanes, is not increased in Down syndrome

Cited by 16 publications

References 26 publications

African Ancestry Gradient Is Associated with Lower Systemic F2‐Isoprostane Levels

African Ancestry Gradient Is Associated with Lower Systemic F2‐Isoprostane Levels

Today’s oxidative stress markers

Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain

Contact Info

Product

Resources

About

African Ancestry Gradient Is Associated with Lower Systemic F₂‐Isoprostane Levels

African Ancestry Gradient Is Associated with Lower Systemic F₂‐Isoprostane Levels