“…Bone lesions in POEMS syndrome often present with both osteosclerotic and osteolytic features [27] . The diffuse osteosclerosis in other malignancies should be differentiated from the non-POEMS, such as myelofibrosis [28] , [29] , acute megakaryocytic leukemia [30] , hairy cell leukemia [31] , systemic mastocytosis [32] , bone lymphoma [33] , and prostate cancer [34] . In brief, diffuse osteosclerosis and elevated bone formation markers in our MM case suggest a hyperactive osteoblastic process.…”