Systemic osteosclerosis associated with primary bone marrow B‐cell lymphoma

Abstract

Systemic osteosclerosis is a rare complication of hematological malignancies. Primary myelofibrosis and acute megakaryocytic leukemia are known as underlying diseases; however, lymphoid tumors have rarely been reported. Here we describe a case of a 50‐year‐old man with severe systemic osteosclerosis associated with primary bone marrow B‐cell lymphoma. Analysis of bone metabolic markers revealed a high turnover of bone metabolism and an increase in serum osteoprotegerin levels. These results suggest the involvement of osteoprotegerin in the pathogenesis of osteosclerosis associated with hematological malignancies.

Non-POEMS osteosclerotic multiple myeloma: Clinical characteristics and differential diagnosis

“…Bone lesions in POEMS syndrome often present with both osteosclerotic and osteolytic features [27] . The diffuse osteosclerosis in other malignancies should be differentiated from the non-POEMS, such as myelofibrosis [28] , [29] , acute megakaryocytic leukemia [30] , hairy cell leukemia [31] , systemic mastocytosis [32] , bone lymphoma [33] , and prostate cancer [34] . In brief, diffuse osteosclerosis and elevated bone formation markers in our MM case suggest a hyperactive osteoblastic process.…”