Systemic Ornidazole as an Adjunct to Non‐Surgical Periodontal Therapy in the Treatment of Chronic Periodontitis: A Randomized, Double‐Masked, Placebo‐Controlled Clinical Trial

Abstract

The systemic use of ORN, when used in conjunction with initial periodontal treatment consisting of SRP in adults with periodontitis, achieves significantly better clinical results than initial periodontal treatment alone.

Non‐surgical periodontal therapy with systemic antibiotics in patients with untreated chronic periodontitis: a systematic review and meta‐analysis

“…The analysis was hampered by the fact that the follow-up period from most of the studies was only 3-6 mo. When analysing only studies that had results at 3, 6 and 12 mo (73,75,80,83,86,92,99), the clinical additional difference of Antibiotics in chronic periodontitis 307 these studies was lower at 3 mo (0.20 mm AE 0.11) and 6 mo (0.26 mm AE 0.15) and higher at 12 mo (0.30 mm AE 0.16) when compared to the overall effect. Overall, it seems that the initial effect of the systemic antibiotics on the mean probing pocket depth difference remains stable for at least 1 year.…”

“…Screening of the reference lists of the full text articles did not result in any additional articles. In Table the main characteristics of the 43 included studies are summarized. Eight authors have provided additional results that were not present in the articles .…”

“…Overall, it seems that the initial effect of the systemic antibiotics on the mean probing pocket depth difference remains stable for at least 1 year. Additionally, when disregarding the antibiotics with only one study in the analysis [AMOX + CLAV , CLA , MOX , ORN , SPI and TET ], it became clear that only for MET + AMOX the mean probing pocket depth difference when compared to SRP could be obtained for up to 1 year.…”

Clinical and microbiological efficacy of 3% satranidazole gel as a local drug delivery system in the treatment of chronic periodontitis: A randomized, controlled clinical trial

“…Few randomized controlled clinical trials have reported success with the use of local delivery of antimicrobials as an adjunct to SRP in the treatment of CP patients. [ 13 33 ] Our previous study has concluded significant improved clinical and microbiological outcomes with systemic use of SZ in CP patients as an adjunct to mechanical periodontal therapy. [ 34 ] Similar to findings in these studies, the results of this study indicate that both therapies (SRP + LDD of placebo in Group 1 and SRP + LDD of 3% SZ in Group 2) resulted in improvement but patients in Group 2 showed enhanced clinical and microbiological outcome ( P < 0.05) over a period of 6 months as compared to Group 1.…”

“…MTZ[ 11 ] and related nitroimidazole derivatives including ornidazole[ 14 ] and tinidazole[ 15 ] have a spectrum of activity against strictly anaerobic microorganisms and have been used successfully in the treatment of periodontal diseases. Satranidazole (SZ) is another antibiotic that belongs to the 5-nitroimidazole group.…”