Systemic or local thrombolysis in high-risk pulmonary embolism

Macovei, Liviu; Presura, Razvan Mihai; Arsenescu-Georgescu, Cătălina

doi:10.5603/cj.a2014.0103

Cited by 19 publications

(15 citation statements)

References 16 publications

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“…There are few randomized studies comparing both types of fibrinolytic administration (systemic vs CDT)[47]. The first study on which the ACCP recommendations are based, was published by Verstraete et al[48].…”

Section: Results Of Endovascular Techniques For the Treatment Of Pementioning

confidence: 99%

Interventional radiology treatment for pulmonary embolism

Gregorio¹,

Guirola²,

Lahuerta³

et al. 2017

WJR

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Venous thromboembolism (VTE) is an illness that has a potentially life-threatening condition that affects a large percentage of the global population. VTE with pulmonary embolism (PE) is the third leading cause of death after myocardial infarction and stroke. In the first three months after an acute PE, there is an estimated 15% mortality among submassive PE, and 68% mortality in massive PE. Current guidelines suggest fibrinolytic therapy regarding the clinical severity, however some studies suggest a more aggressive treatment approach. This review will summarize the available endovascular treatments and the different techniques with its indications and outcomes.

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Section: Results Of Endovascular Techniques For the Treatment Of Pementioning

confidence: 99%

Interventional radiology treatment for pulmonary embolism

Gregorio¹,

Guirola²,

Lahuerta³

et al. 2017

WJR

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“…MB rarely causes dyspnea, tremor, vomiting, blue discoloration of body fluids and acute hemolytic anemia with high doses [39]. A higher dose than 7 mg/kg body weight lead to serotonin syndrome [40][41][42].The ideal dose is unknown, but in the literature is recommended a dose of 1-2 mg/kg body weight as a single bolus [30,43,44].…”

Section: Experimental Part Materials and Methodsmentioning

confidence: 99%

Intraoperative Identification of Lacrimal Sac by Means of Methylene Blue

Bogdănici¹,

Costea²,

Dimitriu³

et al. 2018

Rev. Chim.

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Methylene blue (MB) has many uses in medicine, being applied as a treatment for infections, malaria, methemoglobinemia, as a dye for diagnosis and for staining of cells, tissues and bacteria. In elderly patients with associated high anaesthetic risk, dacryocystectomy is an alternative to dacryocystorhinostomy. This is an observational clinical study for two cases of chronic dacryocystitis where dacryocystectomy combined with MB (1%) staining of lacrimal sac was performed. Case no.1 - an 81-year old female patient with arterial hypertension, atherosclerosis, pulmonary fibrosis, and lower limb varices complainted of recurrent epiphora, muco-purulent secretions in both eyes, inflammatory oedema of the left perisacular region for the past 6 months. Case no. 2 - a 74-year old female patient with hypothyroidism suffered from chronic epiphora in the left eye with a purple-red oedema of the inferior eyelid and perisacular region. Symptoms reoccurred in the last 10 months despite topical and systemic therapy with antibiotics and anti-inflamatory drugs. Dacryocystectomy was performed under local anaesthesia in both patients. MB (1%) was used to irrigate the lacrimal sac in order to facilitate its localisation, dissection and excision. Results: Case no.1. Ectopic lacrimal sac. Case no.2. Enlarged lacrimal sac (7.5/14 mm). The histopathological examination revealed a trachomatous dacryocystitis, respectively a chronic non-suppurative non-granulomatous dacryocystitis. Their postoperative evolution was without complications, except for a mild epiphora. In conclusion, dacryocystectomy appears to be a less traumatising alternative to dacryocystorhinostomy. The staining of the lacrimal sac with MB (1%) in dacryocystectomy facilitates its identification and dissection, especially when it is ectopic.

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“…76 Despite careful screening for contraindications, the rate of major hemorrhage from systemic thrombolytic therapy is ;20%. Catheter-directed thrombolysis (CDT) may be associated with significant in-hospital mortality reductions (0% in 1 study) compared with ;29% with systemic thrombolysis.…”

Section: Thrombolytic Therapymentioning

confidence: 99%

Practical Approach to VTE Management in Hospitalized Patients

Reddy

Dupree

2017

American Journal of Therapeutics

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Venous thromboembolism (VTE) is a commonly feared life-threatening complication in hospitalized patients. Physicians are frequently consulted to diagnose and manage VTE in obstetrics, neurology, and surgical services. VTE should be treated irrespective of the presentation (incidental or symptomatic), etiology (provoked vs. unprovoked), and location of the venous thrombosis (extremities, abdomen, or cerebral). In patients with high clinical suspicion for VTE, physicians are encouraged to empirically start anticoagulant therapy while awaiting diagnostic testing. Thrombolytic therapy is underused by physicians, which is proven to improve the mortality in hypotensive patients with pulmonary embolism. Retrievable inferior vena cava filters have an important role in the prophylaxis and management of selective groups of VTE patients. Physicians should not hesitate to place retrievable inferior vena cava filters when clinically indicated but also should make every effort to remove them when no longer needed. This article extensively reviews various diagnostic and management options based on several clinical situations.

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Systemic or local thrombolysis in high-risk pulmonary embolism

Abstract: (Cardiol J 2015; 22, 4: 467-474)

Cited by 19 publications

References 16 publications

Interventional radiology treatment for pulmonary embolism

Interventional radiology treatment for pulmonary embolism

Intraoperative Identification of Lacrimal Sac by Means of Methylene Blue

Practical Approach to VTE Management in Hospitalized Patients

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