Systemic nonbiologic treatments for hidradenitis suppurativa

Abstract

Hidradenitis suppurativa (HS) is a severe and painful chronic dermatologic condition affecting hair follicles with a significant negative impact on patient quality of life.Effective treatment of HS has proven challenging and often involves multiple modalities. These include topical treatments, systemic antibiotics, retinoids, hormonal therapies, biologic and nonbiologic immunosuppressants, small molecule inhibitors, surgery, and photodynamic/radiation therapy. This review outlines the nonbiologic systemic therapies for HS and describes the latest research on these therapies. Therapies covered in this review include systemic antibiotics, retinoids, hormonal therapies, nonbiologic immunosuppressants, and small molecule inhibitors.