Systemic mycosis due to trichosporon cutaneum a report of two additional cases

Abstract

Two additional cases of systemic mycosis due to Trichosporon cutaneum are reported and are compared with the previously published case of Rivera and Cangir. Both patients (a four-year-old male and a 57-year-old female) had acute leukemia for which they were receiving chemotherapy, and both presented with fever that was unresponsive to conventional antibiotics. Both had positive blood cultures for Trichosporon cutaneum. The disease was further documented in the four-year-old male by renal biopsy and by bone marrow culture; he was treated with apparent success with amphotericin B. However, the 57-year-old female died shortly after the begining of similar treatment, and autopsy demonstrated involvement of the left kidney, spleen, bone marrow, and liver. The organism in both these cases, as well as the case of Rivera and Cangir, exhibited both hyphal and yeastlike forms in tissue sections. We believe that the therapeutic success in the case of the four-year-old male was primarily related to his remission from leukemia.

Generalized lymphadenopathy caused byTrichosporon asahiiin a patient with Job's syndrome

“…Fever, pneumonia and/or skin rash were major clinical manifestations [7][8][9][10]. In several reports prior to Gué ho et al's revision, causal agents of systemic, invasive trichosporonosis were identi ed as T. beigelii or T. cutaneum [32][33][34] or these two species names were used interchangeably [35]. Our patient had nonregressing generalized lymphadenopathy.…”

Postoperative Trichosporon Beigelii Soft Tissue Infection

“…In the areas of chronic granulomatous inflammation where giant cells are found, periodic acid‐Schiff positive fungal elements are seen within histiocytes, in multinucleated giant cells, and in the intercellular space 7 . In tissue, the organism forms predominantly branching and septated hyphae 2.5–3.0 μm in width and yeast forms up to 10 μm in diameter 1, 7, 9 …”

White piedra-a case report and review of the literature

“…Infection has been reported in horses, other domestic animals, and a spider monkey (Smith et al, 1973;Rippon, 1982). It has also been found to colonise human skin (Manzella, Berman & Kukrika, 1982, Haupt et al, 19831 sputum (Rippon, 1982, Haupt et al, 1983, urinary and gastrointestinal tracts (Taplin & Rebell, 1979a, Haupt et al, 1983, and has been regarded as a laboratory contaminant (Evans et al, 1980). Poor personal hygeine, diabetes (Taplin & Rebell, 1979a), and swimming in contaminated water (Rippon, 1982) are said to be predisposing factors in infection.…”