Systemic Metabolic Alterations Associated with Repeated Injections of a Modified Polyriboinosinic-Polyribocytidylic Acid Complex

Powanda, Michael C.; Sammons, Myrl L.; Stephen, Edward L.

doi:10.1128/aac.12.5.602

Cited by 7 publications

(4 citation statements)

References 17 publications

(20 reference statements)

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“…A 2 to threefold increase in haptoglobin, and a dose dependent increase in alpha -2-macrofetoprotein. (Powanda et al, 1977 ).…”

Section: Use Of Acute Phase Proteins In Testing Anti-viral Drugsmentioning

confidence: 98%

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A brief, highly selective history of acute phase proteins as indicators of infection, inflammation and injury

Powanda¹,

Moyer²

2021

Inflammopharmacol

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There is an array of plasma protein alterations that occur in a wide variety of species, including humans in response to trauma, inflammation and infections, seemingly irrespective of etiologic agent. In numerous species, these plasma proteins are part of the innate immune response. In addition, it appears that a number of the plasma proteins in this array can be predictive of morbidity and/or mortality. We propose that based on historic use, selected acute phase proteins should be included in ongoing and future non-clinical and clinical studies to help us better understand disease progression in chronic, as well as acute diseases. In addition to assess if there is a relationship between vaccine-induced inflammation and degree of protection from live, attenuated or synthetic vaccines.

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“…A 2 to threefold increase in haptoglobin, and a dose dependent increase in alpha -2-macrofetoprotein. (Powanda et al, 1977 ).…”

Section: Use Of Acute Phase Proteins In Testing Anti-viral Drugsmentioning

confidence: 98%

“…Both 0.3 and 3.0 mg/kg poly(ICLC) caused increases in seromucoid (primarily consisting of alpha-1-acid glycoprotein and haptoglobin) up to five fold at 48 h. A 2 to threefold increase in haptoglobin, and a dose dependent increase in alpha -2-macrofetoprotein. (Powanda et al, 1977).…”

Section: Use Of Acute Phase Proteins In Testing Anti-viral Drugsmentioning

confidence: 99%

A brief, highly selective history of acute phase proteins as indicators of infection, inflammation and injury

Powanda¹,

Moyer²

2021

Inflammopharmacol

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“…phor-hypoferremia by enhancing the flux of iron bol myristic acetate (20) and polyriboino-into the liver. Taken together these activities sinic-polyribocytidylic acid complexes (21). of LEM/EP/LAF may account, at least in as well as endotoxin (7) elicit LEM/EP/LAF part, for the observed antimicrobial activity release.…”

Section: Lajmentioning

confidence: 79%

Hypothesis: leukocyte endogenous mediator/ endogenous pyrogen/lymphocyte-activating factor modulates the development of nonspecific and specific immunity and affects nutritional status

Powanda¹,

Beisel²

1982

The American Journal of Clinical Nutrition

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We postulate that leukocyte endogenous mediator/endogenous pyrogen/lymphocyte-activating factor (LEM/EP/LAF) integrates the host's nonspecific and specific immune responses to infection by virtue of the panoply of physiological and metabolic activities it is capable of eliciting. The alterations in systemic metabolism modulated by LEM/EP/LAF, although apparently of value to the host in the defense against infection and the repair of tissue damage, result in negative nutrient balances. Severe infections, alone or in conjunction with injury, may result in malnutrition unless the patient is adequately nourished. Preexisting nutritional deficits can compromise host resistance to infection, in part by preventing production of LEM/EP/LAF. Additional studies of the sequelae of LEM/EP/LAF action and effects of nutrition on host resistance to infection appear warranted.

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“…There was no evidence of fever in any of the patients given either of the two treatments. Fever has been related to the use of polynucleotides designed for anti-viral therapy (Powanda et al 1977).…”

Section: Adverse Events and Safetymentioning

confidence: 99%

Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases

2015

Progress in Drug Research

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Systemic Metabolic Alterations Associated with Repeated Injections of a Modified Polyriboinosinic-Polyribocytidylic Acid Complex

Cited by 7 publications

References 17 publications

A brief, highly selective history of acute phase proteins as indicators of infection, inflammation and injury

A brief, highly selective history of acute phase proteins as indicators of infection, inflammation and injury

Hypothesis: leukocyte endogenous mediator/ endogenous pyrogen/lymphocyte-activating factor modulates the development of nonspecific and specific immunity and affects nutritional status

Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases

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