Systemic Mastocytosis Associated With Membranous Nephropathy and Peripheral Neuropathy

Lal, Sunder M.; Brooks, Charles S.; Luger, Alan M.; Davenport, John; Weber, Robert H.; Loy, Timothy S.; Haibach, Helmut

doi:10.1016/s0272-6386(88)80108-2

Cited by 10 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Peripheral neuropathy is a rare condition in patients with SM. To our knowledge, only 1 case of SM has been reported to have peripheral neuropathy that resolved after therapy [6] . In this study, the patient had numbness in both lower limbs, which was confirmed by electromyography as demyelinating lesions of the peripheral nerve.…”

Section: Discussionsupporting

confidence: 67%

A case of systemic mastocytosis mimicking POEMS syndrome

et al. 2022

View full text Add to dashboard Cite

Rationale: POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) syndrome is a rare and complicated disease related to multiple organs and systems. Here, we report a case of systemic mastocytosis (SM) that was misdiagnosed as a POEMS syndrome.Patient concerns: A 42-year-old man presented with skin changes, diarrhea, and limb numbness.Diagnoses: Positron emission tomography/computed tomography revealed extravascular volume overload, organomegaly, lymphadenopathy, and bone lesions with mixed lesions of osteosclerosis and osteolysis. Therefore, POEMS syndrome was suspected. Further histopathological and immunohistochemical examination of the bone marrow, lymph nodes, and gastric mucosa suggested a diagnosis of mastocytosis. The c-Kit D816V mutation confirmed the diagnosis of SM. Interventions:The patient received the treatment of pegylated interferon-alpha weekly and glucocorticoid daily.Outcomes: The symptoms relieved significantly.Lessons: There are many similar features between POEMS syndrome and SM, probably leading to misdiagnosis. This study analyzed the different points between them which can provide help for differentiation.

show abstract

Section: Discussionsupporting

confidence: 67%

A case of systemic mastocytosis mimicking POEMS syndrome

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Kidneys are usually not included in the target organs of SM; in the literature there are only two reports of SM associated with kidney disease without there being any other possible cause of renal failure [9,10]. In one of the two reports, nephrotic syndrome was present as in our patient.…”

Section: Discussionmentioning

confidence: 64%

Systemic Mastocytosis Accompanied by a Non-Secretory Plasma Cell Dyscrasia and Nephrotic Syndrome-Level Proteinuria in a 76-Year-Old Patient

et al. 2013

View full text Add to dashboard Cite

We report here the interesting case of a 76-year-old man with severe proteinuria who was diagnosed with systemic mastocytosis accompanied by a clonal non-mast-cell lineage haematological disorder (a non-secretory plasma cell dyscrasia). This is a unique report of systemic mastocytosis with a non-secretory plasma cell dyscrasia and nephrotic syndrome. The pathophysiological relevance between these entities along with the probability of occult amyloidosis is discussed.

show abstract

“…63 Other neurological conditions have been scarcely described in mastocytosis patients in various case reports. These conditions include parkinsonism, 64 chorea, 65 seizures, 66 syncope, 67 hypotensive shock, 68 encephalopathy due to cerebral hypoxia, 69 peripheral neuropathy, [70][71][72][73] neurosensory deafness, 74 meningeal irritation and compressive myelopathy due to BM infiltration, 71 conus medullaris syndrome, 75 intraspinal tumo 76 and hematomas, 77 and myotonic dystrophy. 78 All these reports were excluded from this review because of the lack of larger cohorts providing data applicable to the general population.…”

Section: Discussionmentioning

confidence: 99%

Cognitive, neuropsychiatric and neurological alterations in mastocytosis: A systematic review

Sagües‐Sesé,

García‐Casares,

Álvarez‐Twose

2023

Clinical & Translational All

View full text Add to dashboard Cite

BackgroundMastocytosis manifests with multisystemic symptoms, often involving the nervous system. Numerous cognitive, neuropsychiatric and neurological alterations have been reported in multiple observational studies.MethodsWe performed a qualitative systematic literature review of reported data consulting the electronic databases Medline, Scopus, Web of Science, Cochrane, and BASE until June 2023.ResultsWe selected 24 studies in which the majority showed that a high proportion of mastocytosis patients suffer cognitive, neuropsychiatric and neurological alterations. The most common disorders and estimated ranges of frequency observed in adults were depression (68%–75%), anxiety, high stress or irritability (27%–54%), cognitive impairment (27%–39%, primarily affecting memory skills), and headaches (55%–69%). Attention challenges and learning difficulties were reported in children at a rate of 13%, while neurodevelopmental disorders occurred at rates of 8%–12%. Frequent white abnormalities in mastocytosis patients with concomitant psychocognitive symptoms have been reported although neuroimaging studies have been performed rarely in this population.ConclusionFurther studies with more comprehensive and homogeneous evaluations and neuroimaging and histological analysis should be performed for a better understanding of these manifestations. An earlier detection and proper management of these symptoms could greatly improve the quality of life of these patients.

show abstract

Systemic Mastocytosis Associated With Membranous Nephropathy and Peripheral Neuropathy

Cited by 10 publications

References 15 publications

A case of systemic mastocytosis mimicking POEMS syndrome

A case of systemic mastocytosis mimicking POEMS syndrome

Systemic Mastocytosis Accompanied by a Non-Secretory Plasma Cell Dyscrasia and Nephrotic Syndrome-Level Proteinuria in a 76-Year-Old Patient

Cognitive, neuropsychiatric and neurological alterations in mastocytosis: A systematic review

Contact Info

Product

Resources

About