Systemic mastocytosis: a possible aetiology of nephrolithiasis

Manion, Sean; Wheeler, John S.

doi:10.1046/j.1464-410x.1996.20628.x

British Journal of Urology

1996

DOI: 10.1046/j.1464-410x.1996.20628.x

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Systemic mastocytosis: a possible aetiology of nephrolithiasis

Sean Manion

John S. Wheeler

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Ureteral stones due to systemic mastocytosis: diagnostic and therapeutic characteristics

Molderings

Solleder²,

Kolck³

et al. 2009

Urol Res

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Urolithiasis is expected to cause a considerable complication in patients with systemic mastocytosis. The aim of the present report is to demonstrate that due to pathological activation and irritability of mast cells, special features in the diagnostic investigation and therapy of urolithiasis have to be considered in patients with systemic mastocytosis. The clinical presentation, diagnostic investigation and therapeutic procedure of urolithiasis in a patient with systemic mastocytosis are described. Urolithiasis may be a significant complication of systemic mastocytosis. Non-contrast CT is the main tool for diagnosing urolithiasis after a detailed history and clinical exam. Patients with systemic mastocytosis should receive a premedication composed of a glucocorticoid and H(1)- and H(2)-histamine receptor antagonists. An increased vulnerability of mucosal tissues is expected in patients with systemic mastocytosis that may limit the options of operative and postoperative therapy. Opioids should be used cautiously for analgesia in patients with systemic mastocytosis.

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Ureteral stones due to systemic mastocytosis: diagnostic and therapeutic characteristics

Molderings

Solleder²,

Kolck³

et al. 2009

Urol Res

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Kidney and urinary tract involvement in systemic mastocytosis

Bharati

Shah

Desai

et al. 2023

Nephrology Dialysis Transplantation

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Systemic mastocytosis (SM) is a disorder of excessive mast cell accumulation in tissues due to a somatic gain-of-function mutation, commonly in the KIT gene, which prevents apoptosis of mast cells. Whereas bone marrow, skin, lymph nodes, spleen, and gastrointestinal tract are commonly involved, kidneys are rarely involved directly by SM. However, there are increasing reports of indirect kidney involvement in patients with SM. Novel anti-neoplastic agents to treat advanced forms of SM include non-specific tyrosine kinase inhibitors, which are reported to be associated with kidney dysfunction in some patients. SM is also associated with immune-mediated glomerulonephritis (GN) like mesangioproliferative GN, membranous nephropathy, and diffuse proliferative GN. Kidney injury, in the form of monoclonal deposition disease and primary light chain amyloidosis, is reported in SM associated with plasma cell dyscrasia. In this narrative review, we discuss the various ways kidneys (and the urinary tract) are involved in patients with SM.

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Systemic Mastocytosis as a Cause of Severe Osteoporosis in a Young Woman

Liakou¹,

Trovas²,

Terpos³

et al. 2010

The Endocrinologist

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Systemic mastocytosis: a possible aetiology of nephrolithiasis

Cited by 3 publications

References 0 publications

Ureteral stones due to systemic mastocytosis: diagnostic and therapeutic characteristics

Ureteral stones due to systemic mastocytosis: diagnostic and therapeutic characteristics

Kidney and urinary tract involvement in systemic mastocytosis

Systemic Mastocytosis as a Cause of Severe Osteoporosis in a Young Woman

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