Systemic mast cell disease

Szweda, John A; Abraham, Joseph; Fine, Gerald; Nixon, Robert K.; Rupe, Clarence E.

doi:10.1016/0002-9343(62)90292-9

Cited by 67 publications

(10 citation statements)

References 38 publications

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“…The enhanced lung pattern on radiographs probably results from infiltration in the lung by the cells: this has been repeatedly confirmed at post-mortem examination [30,43]. The enlargement of lymph nodes, liver and spleen is to be chief ly ascribed to mast cell proliferation, but fibrosis can also play a role [6,16].…”

Section: Discussionmentioning

confidence: 96%

“…Both our pa tients had suffered from gastric or duodenal ulcer, and both showed nor mal gastric acid values. Their ulcers may have been stress ulcers [43].…”

Section: Discussionmentioning

confidence: 99%

“…The results obtained are variable [19,24,39] but particularly short-term results are sometimes very promising [11-X-ray irradiation also causes degranulation of mast cells. This seems to have a favourable effect, particularly in local application to combat, say, deep-seated ostealgia [43]. But for treatment of the entire body the dose required is so large that side effects become predominant.…”

Section: Discussionmentioning

confidence: 99%

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Generalized Mastocytosis

Kammen¹

1974

Acta Haematol

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The case histories of three patients with generalized mastocytosis are presented and discussed. The first patient had extensive urticaria pigmentosa, hepatosplenomegaly, polylymphadenopathy and myelofibrosis. The best therapeutic results were obtained with prednisone in combination with an antihistamine. The second patient showed virtually no skin lesions but had splenomegaly and upper abdominal pains. The latter disappeared after splenectomy. The spleen disclosed a greatly increased histamine concentration. The third patient started with thrombocytopenic purpura that was cured by splenectomy. Seven years later, urticaria pigmentosa developed with mast cell proliferation in skin and bone marrow and a low IgM level. In addition to skin biopsies, determination of histamine in blood and urine can supply valuable diagnostic information, especially in the more advanced cases. In systemic mastocytosis immune deficiency may occur.

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Section: Discussionmentioning

confidence: 96%

“…Both our pa tients had suffered from gastric or duodenal ulcer, and both showed nor mal gastric acid values. Their ulcers may have been stress ulcers [43].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Generalized Mastocytosis

Kammen¹

1974

Acta Haematol

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“…Peptic ulcer disease was documented by upper gastrointestinal roentgenographic study [5,11,13,141, upper endoscopy [ 12,151, coffee-ground emesis [lo] or at autopsy [16]. In two cases, the diagnostic procedure was not mentioned [ 17,181.…”

Section: Literature Reviewmentioning

confidence: 99%

“…The percentage of mast cells observed has ranged from 4% to 96% of the leukocyte count. The majority of authors have used the term mast cell leukemia to describe these cases [5][6][7]10,[12][13][14][15][16]. In an attempt to differentiate mast cell leukemia from malignant mastocytosis with peripheral blood mast cells, Travis et al [14] proposed that the occurrence of at least 10% circulating mast cells at presentation was the most reliable criterion for the diagnosis of mast cell leukemia.…”

Section: Literature Reviewmentioning

confidence: 99%

Malignant mastocytosis with circulating mast cells

et al. 1990

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A case of malignant mastocytosis with peripheral blood involvement is presented. The course of the patient's illness was complicated by recurrent hypotensive episodes, presumed to have been caused by mast cell degranulation. Treatment with hydroxyurea was associated with persistent hypotension which resulted in death. It has been proposed that the diagnosis of mast cell leukemia be given to patients presenting with greater than 10% atypical mast cells in the blood. However, review of 16 published cases of malignant mastocytosis with circulating mast cells reveals that the clinical manifestations, complications, and survival do not vary significantly with the percentage of peripheral blood mast cells. Patients with malignant mastocytosis with significant involvement by atypical mast cells in the bone marrow and peripheral blood should be considered as having an aggressive disease, regardless of the percentage of circulating mast cells.

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Xanthelasmoidea. An unusual case of urticaria pigmentosa

Rasmussen¹

1976

Archives of Dermatology

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Systemic mast cell disease

Cited by 67 publications

References 38 publications

Generalized Mastocytosis

Generalized Mastocytosis

Malignant mastocytosis with circulating mast cells

Xanthelasmoidea. An unusual case of urticaria pigmentosa

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