Systemic lupus erythematosus with choroidopathy and serous retinal detachment

Abstract

Systemic lupus erythematosus associated ocular manifestations usually consist of cotton-wool spots and retinal hemorrhages. The authors report one case of lupus choroidopathy revealed by bilateral serous retinal detachment, occurring 4 months after a systemic flare-up of the disease. An immune complexes-mediated phenomenon is involved in these manifestations, which are usually controlled by systemic corticosteroids and immunosuppressive agents. Plasma exchanges were successfully applied in this case, resulting in a disappearance of the retinal detachment in one month.

Choroidal Thickness in Patients with Systemic Lupus Erythematosus Analyzed by Spectral-domain Optical Coherence Tomography

“…23 Histopathological studies of the eye in SLE have shown inflammatory cell infiltrates within the choroid, as well as immunoglobulin and complement deposition in the choroidal vasculature and damage to the retinal pigment epithelium. 10,24 In SLE, cotton wool patches and retinal hemorrhage are commonly found. 25 But choroidopathy is rare in patients with SLE.…”

“…In these patients, serous retinal detachment secondary to choroidal involvement is reported. [10][11][12][13][14][15][16] Different imaging methods have been used to show the choroidal involvement in patients with SLE. 16,26 Indocyanine green angiography (ICG) is an invasive imaging method used to evaluate vascular structure and tissue inflammation.…”

“…8,9 The choroid has been shown to be affected in patient of SLE in several experimental and clinical studies. [10][11][12][13][14][15][16] Enhanced depth imaging optical coherence tomography (EDI-OCT), which is a recent modification of the standard OCT technique, offers a noninvasive, rapid, objective, and reliable diagnostic modality for the imaging of choroidal alterations and allows in vivo examination and quantification of the choroid. [17][18][19] However, there has been no study of the effect of SLE on choroidal thickness (CT) with EDI-OCT.…”

Ocular manifestations of systemic lupus erythematosus

“…Choroidopathy, uveal effusions, and serous retinal detachment may occasionally occur in patients with SLE [41][42][43][44][45][46]. Significant uveal effusions may also lead to secondary angle-closure glaucoma [47].…”

Choroidopathy and kidney disease: a case report and review of the literature

“…Several groups who have observed bilateral retinal detachments in the setting of SLE have noted abnormalities of the retinal pigment epithelium (RPE) [7,8-10]. Matsuo and colleagues [9] hypothesized that anti-retinal pigment epithelium antibodies were involved in causing a dysfunction of the RPE which ultimately led to the development of serous retinal detachment.…”