Systemic lupus erythematosus revealed by sweet syndrome

Tabache, Fatima; Kartouti, Abdeslam El; Tarib, Abdelilah; Mejareb, Charafeddine El; Hassikou, H.; Baaj, M. El

doi:10.1016/j.jbspin.2011.03.013

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…Our data support the results that atopic dermatitis may be the comorbid disorders associated with SLE . Additionally, our results show that some autoimmune or autoinflammatory diseases may have a close association with SLE, which has been reported by several studies . However, even after adjustment for these comorbidities, a higher risk of SLE was significantly associated with a history of urticaria.…”

Section: Discussionsupporting

confidence: 92%

Clinically diagnosed urticaria and risk of systemic lupus erythematosus in children: A nationwide population‐based case‐control study

Lin

Hung

Hu³

et al. 2018

Pediatric Allergy Immunology

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Section: Discussionsupporting

confidence: 92%

Clinically diagnosed urticaria and risk of systemic lupus erythematosus in children: A nationwide population‐based case‐control study

Lin

Hung

Hu³

et al. 2018

Pediatric Allergy Immunology

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“…DISH is characterized by new bone formation, calcification, and ossification of the anterior longitudinal ligament of the spine and various extra spinal ligaments [ 6 ]. Two recent studies investigated the relationship between serum DKK-1 and DISH [ 30 , 36 ]. Senolt et al [ 30 ] showed that the levels of total serum DKK-1 were significantly lower in patients with DISH than in healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, low serum levels of DKK-1 were associated with more severe spinal involvement in DISH [ 30 ]. However, Aeberli et al [ 36 ] suggested that DKK-1 levels of DISH patients were not different from healthy controls and hence development of DISH is unlikely to be dependent on the Wnt signaling inhibitor DKK-1 [ 36 ]. Consistent with the model of Senolt et al [ 30 ], we suggest that the lower circulating DKK-1 level and higher OSC level in patients with DISH reflect the bone anabolic phenotype of the disease (Fig.…”

Section: Discussionmentioning

confidence: 99%

Correlation of blood bone turnover biomarkers and Wnt signaling antagonists with AS, DISH, OPLL, and OYL

Niu

Lin

Yuan

et al. 2017

BMC Musculoskelet Disord

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BackgroundWnt signaling plays an important role in development and maintenance of many organs and tissues. The most-studied secreted Wnt inhibitors are sclerostin (SOST), Dickkopf-related protein 1 (DKK-1), and secreted frizzled related protein 1 (SFRP-1) which play important roles in bone turnover. The present study investigated the relationship between serum Wnt inhibitors and diseases with excessive ossification structures, such as ossification of posterior longitudinal ligament (OPLL), ankylosing spondylitis (AS), diffuse idiopathic skeletal hyperostosis (DISH), and ossification of yellow ligament (OYL).MethodsTwenty-five patients with AS, DISH, OPLL, or OYL were recruited in this study. Fasting peripheral blood samples were collected from all patients and nine controls. Various biomarkers of bone turnover including osteocalcin (OSC), osteoprotegerin (OPG), SFRP-1, DKK-1, and SOST were investigated.ResultsOur data showed that serum levels of OSC were higher, but Dkk-1 levels were lower in AS, DISH, OPLL, and OYL patients than those in the controls. Serum levels of SFRP-1 were significantly higher in DISH patients than those in the controls. Serum levels of SOST were significantly higher in DISH and OPLL patients than both levels in the controls. Serum levels of OPG were lower in AS patients than those in the controls. Serum levels of OSC were higher in the OPLL patients than those in the AS patients. Serum levels of DKK-1, SFRP-1, SOST, and OPG were not significantly different between the different disease groups.ConclusionsIn this exploratory study, both OSC and DKK-1 levels are correlated with the clinical conditions associated with excessive ossification, indicating that blood OSC and DKK-1 levels may serve as diagnostic biomarkers for AS, DISH, OPLL, and OYL. These findings may also help discover potential drug therapies for management of these diseases in the future.

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Neutrophilic Skin Lesions in Autoimmune Connective Tissue Diseases

et al. 2014

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The pathophysiology of neutrophilic dermatoses (NDs) and autoimmune connective tissue diseases (AICTDs) is incompletely understood. The association between NDs and AICTDs is rare; recently, however, a distinctive subset of cutaneous lupus erythematosus (LE, the prototypical AICTD) with neutrophilic histological features has been proposed to be included in the spectrum of lupus. The aim of our study was to test the validity of such a classification. We conducted a monocentric retrospective study of 7028 AICTDs patients. Among these 7028 patients, a skin biopsy was performed in 932 cases with mainly neutrophilic infiltrate on histology in 9 cases. Combining our 9 cases and an exhaustive literature review, pyoderma gangrenosum, Sweet syndrome (n = 49), Sweet-like ND (n = 13), neutrophilic urticarial dermatosis (n = 6), palisaded neutrophilic granulomatous dermatitis (n = 12), and histiocytoid neutrophilic dermatitis (n = 2) were likely to occur both in AICTDs and autoinflammatory diseases. Other NDs were specifically encountered in AICTDs: bullous LE (n = 71), amicrobial pustulosis of the folds (n = 28), autoimmunity-related ND (n = 24), ND resembling erythema gyratum repens (n = 1), and neutrophilic annular erythema (n = 1). The improvement of AICTDS neutrophilic lesions under neutrophil targeting therapy suggests possible common physiopathological pathways between NDs and AICTDs.

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Systemic lupus erythematosus revealed by sweet syndrome

Cited by 5 publications

References 10 publications

Clinically diagnosed urticaria and risk of systemic lupus erythematosus in children: A nationwide population‐based case‐control study

Clinically diagnosed urticaria and risk of systemic lupus erythematosus in children: A nationwide population‐based case‐control study

Correlation of blood bone turnover biomarkers and Wnt signaling antagonists with AS, DISH, OPLL, and OYL

Neutrophilic Skin Lesions in Autoimmune Connective Tissue Diseases

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