Systemic lupus erythematosus may have an early effect on peripheral nerve function in patients without clinical or electrophysiological neuropathy: comparison with age- and gender-matched controls

Fong, Sue-Yng; Raja, Jasmin; Wong, Kum-Thong; Goh, Khean Jin

doi:10.1007/s00296-020-04610-8

Cited by 5 publications

(6 citation statements)

References 15 publications

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“…on the foot) and expanding proximally, although electrophysiological examinations reveal asymmetry in nerve conduction. 24 When muscle weakness is the first symptom in SLE, as in our patient, special attention should be paid to the identification of motor neuron disease. Motor neuron disease is a group of progressive degenerative disorders of unknown etiology.…”

Section: Discussionmentioning

confidence: 77%

“… 21 – 23 SLE with peripheral nervous system involvement is also common. Approximately 21–42% of all SLE patients have abnormalities in nerve conduction tests, 24 but the symptomatic SLE-related peripheral neuropathy incidence rate is very low in the clinic, at only 4.9–7.6% of SLE patients with neuropsychiatric manifestations. 8 , 25 The ACR defines seven types of peripheral neuropathy: acute inflammatory demyelinating polyradiculoneuropathy (Guillain–Barré syndrome (GBS)), autonomic disorder, mononeuropathy, myasthenia gravis, cranial neuropathy, plexopathy, and polyneuropathy 26 ; however, CIDP is not included.…”

Section: Discussionmentioning

confidence: 99%

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Progressive muscle weakness and amyotrophy during pregnancy as the first manifestation of systemic lupus erythematosus: A case report and review of literature

Wang

Ruan

et al. 2021

Science Progress

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Background: Systemic lupus erythematosus is a common autoimmune disease involving multiple systems. Clinical involvement of the central and peripheral nervous systems is not unusual, but peripheral neuropathy in systemic lupus erythematosus with chronic inflammatory demyelinating polyneuropathy is uncommon. Our study aimed to illustrate the clinical features, diagnosis, and treatment of systemic lupus erythematosus combined with chronic inflammatory demyelinating polyneuropathy, and to aid in the identification of peripheral neuropathy in systemic lupus erythematosus. Methods: This article reports a case of systemic lupus erythematosus with onset in pregnancy, with chronic inflammatory demyelinating polyneuropathy as the first manifestation. We then analyze the identification of common peripheral neuropathy in systemic lupus erythematosus in detail, based on a literature review of confirmed cases of systemic lupus erythematosus combined with chronic inflammatory demyelinating polyneuropathy. Results: A 34-year-old woman presented progressive muscle weakness and muscular atrophy in the extremities during pregnancy, 3 years previously. At 4 months after onset, she had completely lost the ability to hold objects and walk, and had slight numbness in the limbs, without paresthesia. Her condition was misdiagnosed as “motor neuron disease” at the time. Three years after onset, her condition was revisited because of nephrotic syndrome, and she was diagnosed with nephrotic syndrome and peripheral nerve injury caused by systemic lupus erythematosus. After immunosuppressive treatment with corticosteroids and intravenous cyclophosphamide, her symptoms of muscle weakness were markedly improved. This article summarizes the characteristics of systemic lupus erythematosus combined with chronic inflammatory demyelinating polyneuropathy that have been reported in the literature, from the aspects of morbidity, disease progression, nerve injury, laboratory examinations, and treatment response. Conclusions: Our identification of a common peripheral neuropathy in systemic lupus erythematosus will help to improve clinicians’ understanding of various peripheral neuropathies in systemic lupus erythematosus. It will also aid in the early diagnosis and treatment of such patients, thus improving their long-term prognosis.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Progressive muscle weakness and amyotrophy during pregnancy as the first manifestation of systemic lupus erythematosus: A case report and review of literature

Wang

Ruan

et al. 2021

Science Progress

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“…Twenty two percent of our patients had peripheral neuropathy, but when we compare our two groups, we find that 40% of active SLE patients had peripheral neuropathy compared to only 2% of nonactive SLE patients. SLE has been shown to impair peripheral nerve function even before patients develop electrophysiological or clinical neuropathy, according to multiple studies (30)(31)(32) . Further analysis of our data using Pearson correlation reveals a statistically significant correlation between peripheral nerve dysfunction and vitamin D levels in both SLE groups, indicating that vitamin D plays a role in the development of SLE-related neuropathy.…”

Section: Discussionmentioning

confidence: 99%

Hypovitaminosis D and Systemic Lupus Erythematous Activity and Related Neuropathy: Clinical Correlation

Afifi¹,

Rizk²,

Halim³

et al. 2021

The Egyptian Journal of Hospital Medicine

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“…Among patients with SLE, 7.6% experience peripheral nervous system events, including peripheral neuropathy ( 35 ). SLE may have an early effect on peripheral nerve function in patients without clinical or electrophysiological neuropathy ( 36 ). However, little is known about the interactions among peripheral nerves in the EIME of the skin.…”

Section: Loops In Systemic Lupus Erythematosusmentioning

confidence: 99%

Inflammatory loops in the epithelial–immune microenvironment of the skin and skin appendages in chronic inflammatory diseases

Dainichi,

Iwata

2023

Front. Immunol.

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The epithelial–immune microenvironment (EIME) of epithelial tissues has five common elements: (1) microbial flora, (2) barrier, (3) epithelial cells, (4) immune cells, and (5) peripheral nerve endings. EIME provides both constant defense and situation-specific protective responses through three-layered mechanisms comprising barriers, innate immunity, and acquired immunity. The skin is one of the largest organs in the host defense system. The interactions between the five EIME elements of the skin protect against external dangers from the environment. This dysregulation can result in the generation of inflammatory loops in chronic inflammatory skin diseases. Here, we propose an understanding of EIME in chronic skin diseases, such as atopic dermatitis, psoriasis, systemic lupus erythematosus, alopecia areata, and acne vulgaris. We discuss the current treatment strategies targeting their inflammatory loops and propose possible therapeutic targets in the future.

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Systemic lupus erythematosus may have an early effect on peripheral nerve function in patients without clinical or electrophysiological neuropathy: comparison with age- and gender-matched controls

Cited by 5 publications

References 15 publications

Progressive muscle weakness and amyotrophy during pregnancy as the first manifestation of systemic lupus erythematosus: A case report and review of literature

Progressive muscle weakness and amyotrophy during pregnancy as the first manifestation of systemic lupus erythematosus: A case report and review of literature

Hypovitaminosis D and Systemic Lupus Erythematous Activity and Related Neuropathy: Clinical Correlation

Inflammatory loops in the epithelial–immune microenvironment of the skin and skin appendages in chronic inflammatory diseases

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