Systemic Lupus Erythematosus-Like Syndrome in Monkeys Fed Alfalfa Sprouts: Role of a Nonprotein Amino Acid

Mr, Malinow; Ej, Bardana; Pirofsky, Bernard; Craig, Shirley S.; McLaughlin, P.

doi:10.1126/science.7071589

Cited by 135 publications

(42 citation statements)

References 19 publications

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“…A small number of tentative, but nevertheless provocative, observations suggest relationships between foods and rheumatic diseases. These include associations of palindromic rheumatism with sodium nitrate hypersensitivity (20), black walnut ingestion with BehGet's syndrome (2 l), canavanine in alfalfa with systemic lupus erythematosus (22), fasting with an antirheumatic effect (5,8,9), chemical or food challenges (particularly wheat, corn, and beef) with symptomatic arthritis (3, RA with dairy products (23), food and tartrazine sensitivity with RA (24,25), systemic lupus erythematosus with environmental exposure to hydrazine (26), and rheumatoid-like synovitis in rabbits with consumption of cow's milk (27). We found that a particular prescribed diet (4) was of no demonstrable benefit compared with a placebo diet for RA.…”

Section: Discussionmentioning

confidence: 99%

Food‐induced (allergic) arthritis. Inflammatory arthritis exacerbated by milk

Panush

Stroud

Webster

1986

Arthritis & Rheumatism

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Suggestive, but largely unproven, observations have associated arthritis with environmental antigens, including foods. We studied a patient with inflammatory arthritis in a prospective, “blinded,” controlled fashion to determine whether her symptoms were associated with food sensitivities. This 52‐year‐old white woman with 11 years of class I, stage I, active disease, had symptomatic exacerbations allegedly associated with meat, milk, and beans. We observed an increase in symptoms following an unblinded food challenge and then studied her in our clinical research unit. On her normal diet for 6 days, she averaged 30 minutes of morning stiffness, 9 tender joints, 3 swollen joints, 87% subjective assessment (100% = best possible), and 89% examiner assessment. While she was fasting (3 days) or taking Vivonex (2 days), we noted no morning stiffness, tender joint score of 1, swollen joint score of 0, and assessments of 100% (P < 0.05 versus normal diet). She was then nourished with Vivonex for 33 days without difficulty and challenged in a blinded fashion at mealtimes with lyophilized foods placed into opaque capsules. Four milk challenges (equivalent to ≧8 ounces per meal) produced up to 30 minutes of morning stiffness, 14 tender joints, 4 swollen joints, subjective assessment of 85%, and objective assessment of 80% (P < 0.05 versus fasting‐Vivonex), peaking 24–48 hours postchallenge. Placebo and other foods (lettuce and carrots) were without effect. Immunologic studies suggested both delayed and immediate cutaneous reactivity to milk, no elevation in IgE anti‐milk, marked increases of IgG and IgG4 anti‐milk levels, marginally increased IgG‐milk circulating immune complexes, and in vitro cellular sensitivity to milk. These data relate symptomatic exacerbation of inflammatory arthritis with immunologic hypersensitivity to milk in this patient. This observation suggests new insights in the pathogenesis of inflammatory joint disease and its therapeutic control.

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Section: Discussionmentioning

confidence: 99%

Food‐induced (allergic) arthritis. Inflammatory arthritis exacerbated by milk

Panush

Stroud

Webster

1986

Arthritis & Rheumatism

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“…Both M. sativa seed and herb have been reported to induce a systemic lupus erythematosus (SLE)-like syndrome in female monkeys (Barnes et al 2007;Boon & Smith, 2004;Brinker, 2001;Malinow et al, 1982aMalinow et al, , 1982b. This activity has been attributed to canavanine, a nonprotein amino acid constituent, which has been found to have effects on human immunoregulatory cells in vitro (Jorge et al, 1985).…”

Section: Toxicity/side-effectsmentioning

confidence: 99%

Phytochemical and pharmacological potential ofMedicago sativa: A review

Bora¹,

Sharma²

2010

Pharmaceutical Biology

138

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“…Hydrazine, an organic solvent, similar to hydralazine, which is an antihypertensive associated with lupus, can cause a lupuslike syndrome from occupational exposure via inhalation (8). Other environmental chemicals, for example, an amino acid analogue found in alfalfa sprouts (9), can induce lupus. If a person develops an autoimmune disease, the first question he or she is ask- ed by a clinician is if they are taking any medications, and if so, these are discontinued as the possible cause of the autoimmune process with in many cases a curative outcome.…”

Section: Clinical Research Priorities: Vocs In Human Healthmentioning

confidence: 99%

Approaches for assessing health risks from complex mixtures in indoor air: a panel overview.

Henry

Fishbein

Meggs

et al. 1991

Environ Health Perspect

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Critical to a more definitive human health assessment of the potential health risks from exposure to complex mixtures in indoor air is the need for a more definitive clinical measure and etiology of the health effects of complex mixtures. This panel overview highlights six of the eight presentations of the conference panel discussion and features a number of the major topical areas of indoor air concern. W. G. Meggs assessed clinical research priorities with primary focus on the role of volatile organic chemicals in human health, recognizing the areas where definitive data are lacking. By recognizing many types of chemical sensitivity, it may be possible to design studies that can illuminate the mechanisms by which chemical exposure may cause disease. The critically important topic of multiple chemical sensitivity was discussed by N. A. Ashford, who identified four high risk groups and defined the demographics of these groups. P. A. Schulte addressed the issue of biological markers of susceptibility with specific considerations of both methodological and societal aspects that may be operative in the ability to detect innate or inborne differences between individuals and populations. Three case studies were reviewed. H. Anderson discussed the past and present priorities from a public health perspective, focusing on those issues dealing with exposures to environmental tobacco smoke and formaldehyde off-gassing from materials used in mobile home construction. J. J. Osborne described several case studies involving wood smoke exposure to children, with emphasis on the significantly greater occurrence of chronic respiratory symptoms and acute chest illness for children from homes heated with woodburning stoves.(ABSTRACT TRUNCATED AT 250 WORDS)

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Systemic Lupus Erythematosus-Like Syndrome in Monkeys Fed Alfalfa Sprouts: Role of a Nonprotein Amino Acid

Cited by 135 publications

References 19 publications

Food‐induced (allergic) arthritis. Inflammatory arthritis exacerbated by milk

Food‐induced (allergic) arthritis. Inflammatory arthritis exacerbated by milk

Phytochemical and pharmacological potential ofMedicago sativa: A review

Approaches for assessing health risks from complex mixtures in indoor air: a panel overview.

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