Systemic lupus erythematosus in Egyptian children

Abstract

The aim of the study was to study the characteristics of systemic lupus erythematosus (SLE) in the Egyptian population, comparing it to other populations. We retrospectively studied 207 patients with SLE diagnosed between 1990 and 2005. We obtained clinical features and laboratory data and analyzed them statistically. We studied 151 female and 56 male SLE patients. The female to male ratio was 2.7 to 1 and the mean age at presentation was 10 +/- 2.7 years (range 2-16). The mean disease duration was 6.47 +/- 3.74 years. At diagnosis, musculoskeletal, constitutional and mucocutaneous manifestations were the commonest features. During follow-up, the prevalence of nephritis (67%), hematological manifestations (44.9%), photosensitivity (44%), arthritis (39%), malar rash (38.2%), serositis (32.9%) and neuropsychiatric manifestations (24.25%) increased significantly. Those whose age of onset of the disease was <or=5 years (nine patients) had significantly more common hematological affection (P value = 0.0005). The characteristics of SLE in Egyptian patients show some similarities to other series of Middle Eastern countries, but with a lower female to male ratio. Disease onset below 5 years is extremely rare (4.35%), commonly presenting with hematological manifestations. The kidney was the commonest major internal organ involved, and also an important cause of death.

Clinical presentations and outcomes of Filipino juvenile systemic lupus erythematosus

“…The frequency of renal involvement in our study (62.8%) was comparable to the studies from Taiwan (58.8%) [5] and Trinidad (63.6%)[10]. Among the clinical features found throughout the entire clinical course, the cumulative frequency of hematologic (69.2%) and neuropsyschiatric (32%) involvement in our series is comparable to other studies [9,13-16]. However, arthritis still remained low throughout the course of illness in our patient population compared to other studies [13,14,16,17].…”

“…We reported 8 yr old as the youngest age at initial SLE diagnosis. This is relatively old compared to other series with reported youngest age at 2 to 7 years old [9-12]. Female preponderance, similar from reports of other countries, emphasizes the importance of hormonal factors in the clinical expression of the disease.…”

“…Our patients had fewer reports of arthritis but a significantly higher neuropsychiatric manifestations compared to the other local study done by Hamijoyo[12,13] as well as with that of Taiwan [5] and Egypt [9]. The frequency of renal involvement in our study (62.8%) was comparable to the studies from Taiwan (58.8%) [5] and Trinidad (63.6%)[10].…”

Systemic Lupus Erythematosus in Children and Adolescents

“…Table 2 summarizes the frequencies of the common manifestations of cSLE. 7,12-17 SLE can affect any organ system, and leads to glomerulonephritis and central nervous system involvement arguably more often in cSLE than in adults with SLE.…”

Juvenile-Onset Systemic Lupus Erythematosus: Clinical Features and Current Diagnostic Approaches

“…От 60 до 90% пациентов с ювенильным дебютом СКВ име-ют поражение кожных покровов и слизистых оболочек [7,12,13]. «Визитной карточкой» СКВ со времен описания Rogerius является эритематозная, слегка приподнимающа-яся над уровнем кожи незудящая сыпь, распространяюща-яся на область переносицы и скул и напоминающая по форме крылья бабочки, которая возникает у 60-85% детей (рис.…”