Systemic lupus erythematosus in a multiethnic cohort: LUMINA XXXV. Predictive factors of high disease activity over time

Gs, Alarcón; Calvo‐Alén, Jaime; McGwin, Gerald; Uribe, A G; Toloza, Sergio; Roseman, Jeffrey M.; Fernández, Mónica; Fessler, Barri J.; Vilá, Luis M.; Ahn, Chul Soo; Tan, Filemon K.; Reveille, John D.

doi:10.1136/ard.2005.046896

Cited by 104 publications

(76 citation statements)

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“…21 Swaak et al 22 reported a decreased risk of exacerbation with advancing age. More recently, similar results were reported from the LUMINA cohort by Alarcon et al 2 Tomioka et al reported an increased incidence of exacerbations among young SLE patients, 23 but no information about disease duration was presented. Mirzayan et al found no correlation between flare rate and age.…”

Section: Discussionsupporting

confidence: 70%

SLE disease patterns in a Danish population-based lupus cohort: an 8-year prospective study

Laustrup

Voß

Green

et al. 2009

Lupus

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In 1995 all systemic lupus erythematosus (SLE) patients in the county of Funen were retrieved from four separate and independent sources as part of an 8-year prospective study to determine the pattern of disease activity and damage accumulation in a community based lupus cohort of predominantly Scandinavian ancestry. Incident cases were subsequently identified by surveillance of these sources. Established and new cases underwent annual, structured interviews, clinical examination and blood sampling. The Systemic Lupus Erythematosus Diseases Activity Index SLEDAI and Systemic Lupus International Collaborating Clinics SLICC scores were calculated. Flares were defined as modified - SLEDAI >or= 4. The annual flare rate in definite SLE (D-SLE) was 0.21 (95%CI 0.18-0.24) versus 0.03 (95%CI 0.01-0.07) in incomplete SLE (I-SLE). Forty-three per cent of the entire study population had no disease exacerbations. Infections requiring hospital admission and thrombocytopenia were significantly more frequent among patients with relapsing disease (p < 0.04-0.01). Patients with flares had slightly shorter disease duration and were younger at disease onset than patients with a quiescent course. The most recently diagnosed patients had the lowest annual rate of damage accrual. According to flare rate, two major subsets of almost equal size were identified - one having a long quiescent course, the other exhibiting relapses alternating with remissions. An increased risk of flares was associated with short disease duration and younger age at disease onset, infections requiring hospital admission and thrombocytopenia. Temporal damage increment was the lowest in the most recently diagnosed patients.

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Section: Discussionsupporting

confidence: 70%

SLE disease patterns in a Danish population-based lupus cohort: an 8-year prospective study

Laustrup

Voß

Green

et al. 2009

Lupus

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“…For this reason, there may be greater variance in our data due to ethnic heterogeneity than in the UK cohorts. SLE disease severity and outcomes are known to vary according to ethnicity and socioeconomic status,38 39 and thus the socioeconomic status, ethnicity and disease and medical care services may pose additional concerns among US patients, which may not be relevant to UK patients.…”

Section: Discussionmentioning

confidence: 99%

Lupus-specific health outcome measure for US patients: the LupusQoL-US version

et al. 2009

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“…Younger patients show a poorer prognosis in terms of major organ involvement29 – 31 as well as higher disease activity when compared with older patients 32. Moreover, the socioeconomic status of the patient has been consistently found to influence the prognosis of the disease;10 this is particularly the case for lack of health insurance 33 – 35.…”

Section: Discussionmentioning

confidence: 99%

Systemic lupus erythaematosus in a multiethnic US cohort (LUMINA) LIII: disease expression and outcome in acute onset lupus

et al. 2007

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Systemic lupus erythematosus in a multiethnic cohort: LUMINA XXXV. Predictive factors of high disease activity over time

Cited by 104 publications

References 20 publications

SLE disease patterns in a Danish population-based lupus cohort: an 8-year prospective study

SLE disease patterns in a Danish population-based lupus cohort: an 8-year prospective study

Lupus-specific health outcome measure for US patients: the LupusQoL-US version

Systemic lupus erythaematosus in a multiethnic US cohort (LUMINA) LIII: disease expression and outcome in acute onset lupus

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