Systemic lupus erythematosus: clinical expression and anti-Ro/SS—A response in patients with and without lesions of subacute cutaneous lupus erythematosus

Lόpez-Longo, FJ; Monteagudo, I.; González, CM; Grau, Raquel; Carreño, Luis

doi:10.1177/096120339700600105

Cited by 24 publications

(25 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is little evidence that anti-ENA specificity or titres reflect SLE activity, 68 73 but anti-Ro is associated with cutaneous involvement in subacute cutaneous lupus erythematosus, 74 and with congenital heart block (CHB). 75 Anti-Ro52 in isolation is associated with CHB but is not detected by assays containing only Ro-60, 76 such as HEp-2000 cells.…”

Section: Monitoringmentioning

confidence: 99%

The use of laboratory tests in the diagnosis of SLE

Egner

2000

Journal of Clinical Pathology

267

197

View full text Add to dashboard Cite

Section: Monitoringmentioning

confidence: 99%

The use of laboratory tests in the diagnosis of SLE

Egner

2000

Journal of Clinical Pathology

267

197

View full text Add to dashboard Cite

“…The diagnosis of SLE was based on fulfillment of 4 or more of the ACR criteria. 6 Clinical and laboratory data were obtained from reviews of medical records from the practices. Medical records were also obtained from each patient's primary care physician, nephrologist, hematologist, and neurologist, when applicable.…”

Section: Methodsmentioning

confidence: 99%

“…We did not exclude patients with SCLE who fulfilled the ACR diagnostic criteria for SLE. 6 Control subjects were selected from patients with SLE who were followed up by physicians at Rheumatology Associates, Louisville. Patients with SLE consenting to participate in our research project were matched by age (±2 years), sex, and ethnicity with at least 1 of our patients with SCLE.…”

Section: Methodsmentioning

confidence: 99%

“…5 However, reports of severe systemic disease occurring in patients with SCLE suggest that the full spectrum of LEassociated disease is possible. 4,6 We are aware of only 1 case-control study 7 of patients with SCLE and SLE, which revealed similar frequency and severity of systemic disease in age-and sex-matched patients. The purpose of the present investigation was to review a larger group of patients with SCLE (follow-up, 2 to Ͼ10 years) and to compare them with a cohort of patients (matched for age, sex, and ethnicity) with SLE and without SCLE skin lesions and followed up in a rheumatology practice.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Frequency and Severity of Systemic Disease in Patients With Subacute Cutaneous Lupus Erythematosus

Black

Hornung²,

Schneider³

et al. 2002

Arch Dermatol

View full text Add to dashboard Cite

“…Most previous studies comparing patients with SCLE versus those with only SLE have demonstrated that patients with SCLE are less likely to have severe renal and central nervous system disease, suggesting that SCLE differs from SLE by involving less internal organ disease [31][32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Which Skin Lupus Criteria are of More Value in Determining the Disease: A Greater View with the Help of Direct Immune Fluorescent (DIF)

Emamzadehfard¹,

Ghannadan²

2016

J Clin Med Genomics

View full text Add to dashboard Cite

Background: Lupus erythematosus (LE) includes a spectrum of auto immune disorders, involving whole body (systemic LE) in one end and is cutaneous limited LE on the other side. Cutaneous LE mainly diagnosed via clinical manifestations as well as histopathologic examination. According to different pathologic specifications, the aim of present study was to determine which histopathologic criterion is more accurate and practical in diagnosing cutaneous LE. Material and Methods:The Samples which have been taken were from the patients with clinical manifestations of Cutaneous LE with pathologic confirmation. All patients had direct immuno fluorescent (DIF) samples that recorded. Histopathologic findings are categorized into three groups: group 1 contains epidermal changes, group 2 includes interface changes and group 3 contains dermal changes. Different histopathologic finding such as prevascular infiltration, follicular atrophy, follicular plaque, and basements membrane thickness and other changes, as well as DIF patterns, were recorded in designed questionnaires. Further analysis had been done with SPSS software version 22. Results:Of 145 patients (61.4% female and 38.6% male) in 58.6% DLE was the first clinical diagnosis, 23% was the second and in subsequent 4.1%, 1.4% and 0.7% was third, fourth and fifth diagnosis respectively. In 11% of caeses DLE was not among clinical impressions. DIF was positive in 49%. As a whole, superficial perivascular and perifolicular infiltration were observed in 99% of the cases and was the commonest pathologic feature followed by basal vacuolization, peri follicular infiltration and epidermal atrophy. Other pathologic changes were observed with variable rates.Discussion: By grouping histopathologic criterion, it seems that hyperkeratosis and thickening of Basement membrane may be major histologic criterion and peri vascular infiltration, peri follicular infiltration and eccrine gland infiltration, may be minor. Keywords IntroductionGenetic, hormones, and environment play altogether to give birth to lupus erythematosus (LE); a disease of autoimmune features with a more frequency in women especially in childbearing age which can present variously in different involved organs. The aforesaid disease could be manifested from a skin lesion (cutaneous lupus) to a fatal diffused type (systemic lupus erythematosus [SLE]). LE is clinically divided to three classes: systemic lupus with acute onset, sub-acute cutaneous type, and a chronic discoid form (discoid lupus erythematosus [DLE]). Occurring two to three times more often than SLE, cutaneous lupus is a variant of LE being able to bother the patients' daily life [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15].On the other side, DLE is characterized by well-defined erythematosus scaly patches mostly seen on face and other sun exposed areas; palmoplantar lesions are rarely seen in DLE and can be disabling to the patients especially when we know they are refractory to the conventional treatments [16][17][18][19]. There is a variant...

show abstract

Systemic lupus erythematosus: clinical expression and anti-Ro/SS—A response in patients with and without lesions of subacute cutaneous lupus erythematosus

Abstract: The presence of SCLE lesions in patients with SLE is associated with a more favourable prognosis. The major anti-Ro/SS-A response is directed against the native 60 kD Ro/SS-A protein.

Cited by 24 publications

References 47 publications

The use of laboratory tests in the diagnosis of SLE

The use of laboratory tests in the diagnosis of SLE

Frequency and Severity of Systemic Disease in Patients With Subacute Cutaneous Lupus Erythematosus

Which Skin Lupus Criteria are of More Value in Determining the Disease: A Greater View with the Help of Direct Immune Fluorescent (DIF)

Contact Info

Product

Resources

About