Systemic lupus erythematosus and risk of sexual dysfunction: A systematic review and Meta-Analysis

Jin, Zhao; Yang, Cong; Xiao, Changfu; Wang, Zizhen; Zhang, Suxin; Ren, Jie

doi:10.1177/0961203320974081

Cited by 10 publications

(6 citation statements)

References 43 publications

(50 reference statements)

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“…Our study mainly evaluated the effects of life status and depression in both the SLE and control groups. The results indicated that the prevalence of female sexual dysfunction between the two groups did not exhibit a significant difference, which was not reported in previous meta-analyses [8,9].…”

Section: Discussioncontrasting

confidence: 73%

“…Regarding SLE, studies have reported that the factors affecting patients' sexual function may be caused by the disease itself, mental health disorders (e.g., depression and anxiety), and drug treatment [6,7]. Previous metaanalyses have revealed that SLE has potential adverse effects on the sexual function in women with SLE; however, no further analysis of specific performance and treatment has been conducted [8,9].…”

Section: Introductionmentioning

confidence: 99%

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The effect of systemic lupus erythematosus on sexual function in women: an updated meta-analysis based on cross-sectional studies

2022

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Background Systemic lupus erythematosus (SLE), a chronic systemic autoimmune disease, often affects different organs and tissues. It can be effectively managed using drugs; however, attention should be paid to the patient’s quality of life. This study aimed to evaluate the effect of SLE on female sexual function based on current literature. Methods The PubMed, Embase, and Cochrane Library databases were searched for eligible studies published up to November 9, 2021. This review included all English studies that compared the sexual function between women with SLE and healthy women. A meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results A total of 367 records were retrieved from 3 electronic databases. Five studies that involved 710 women with SLE and 2059 healthy women were finally included in this meta-analysis. The result indicated a significant decrease (mean difference = − 1.74, 95% confidence interval − 3.14 to − 0.34, p = 0.02) in the total scores of the Female Sexual Function Index in women with SLE, implying that healthy women had better sexual function than those with SLE. Conclusion The results of our study indicated that SLE could negatively affect the quality of sexual life in terms of desire, arousal, and pain. Thus, close attention should be paid to the sexual function of women with SLE. Trial registration: This study was registered in the International Prospective Register of Systematic Reviews (registration number: CRD42021290439).

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Section: Discussioncontrasting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

The effect of systemic lupus erythematosus on sexual function in women: an updated meta-analysis based on cross-sectional studies

2022

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“… 4 A meta-analysis of 8 studies involving 758 patients in the SLE group and 1724 individuals in the control group showed that SLE was significantly associated with an increased risk of sexual dysfunction. 5 However, a few studies have explored the association of demographic data and clinical manifestations with intimacy in patients with SLE, especially in Asian populations. 4 6 We hypothesised that demographic factors, clinical manifestations and disease activity of SLE would affect the intimate relationships in female patients with SLE.…”

Section: Introductionmentioning

confidence: 99%

“…Vascular disease was found to be a significant and independent risk factor for impaired sexual function 4. A meta-analysis of 8 studies involving 758 patients in the SLE group and 1724 individuals in the control group showed that SLE was significantly associated with an increased risk of sexual dysfunction 5. However, a few studies have explored the association of demographic data and clinical manifestations with intimacy in patients with SLE, especially in Asian populations 4 6.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with intimacy in female Taiwanese patients with systemic lupus erythematosus: a cross-sectional study

Hsu¹,

Hsu

Koo

et al. 2022

BMJ Open

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ObjectiveThe aim of this study was to investigate the association of demographic factors, clinical manifestations and disease activity of systemic lupus erythematosus (SLE) with intimate relationships in female patients with SLE.DesignThis was a cross-sectional study based on questionnaires.SettingThis study was conducted at a regional teaching hospital in southern Taiwan from April to September 2019.ParticipantsAdult patients with SLE recruited from the outpatient rheumatology clinics of the study hospital.Primary outcome measureDisease-specific quality of life assessed using the Lupus Quality of Life questionnaire (LupusQoL).ResultsA total of 243 female patients with SLE were enrolled. The results of the multiple linear regression analysis indicated that the independent factors associated with a higher score in the intimate relationships domain of the LupusQoL included the age group under 40 years (p=0.001), education level of college or above (p=0.005), being employed (p<0.001), a better self-reported health status (p=0.012) and a lower SLE-Disease Activity Score (SLE-DAS) score (p=0.010). In addition, the intimate relationships domain was significantly and independently associated physical health (p=0.001), fatigue (p=0.006) and burden to others (p=0.002) domains of the LupusQoL.ConclusionsPhysicians should be vigilant regarding the intimate relationships aspect of the health-related quality of life in female patients with SLE, especially in those who are older, unemployed, have a low educational level, poor self-reported health status, higher SLE-DAS, fatigue, and feeling of burden to others.

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“…A recent meta-analysis [8] revealed the rate of sexual dysfunction (SD) in SLE patients, ranging from 15% to 85.9%, which indicated the severity of the poor assessment and management of these issues. Over the past several years, only a handful of studies [9][10][11][12] used a validated tool of the Female Sexual Function Index (FSFI) to explore the relationship between SLE and sexual problems, demonstrating that SLE was associated with an increased risk of female sexual problems.…”

Section: Introductionmentioning

confidence: 99%

Fatigue have impact on the sexual problems in Chinese females with systemic lupus erythematosus

Zhang

2022

BMC Women's Health

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Background Systemic lupus erythematosus (SLE) might affect all aspects of life including sexual function; previous study indicated that fatigue was the risk factor of sexual dysfunction. The current study aims to investigate the effects of SLE on Chinese mainland female patients’ sexual problems compared with healthy subjects and to investigate the relationship among fatigue, disease parameters, depression, quality of life and sexual problems in Chinese female patients with SLE. Methods A total of 128 female SLE patients (mean age: 43.65 ± 7.13 years) and 121 healthy female controls (mean age 43.59 ± 6.57 years) were included in this cross-sectional study. All data were collected consecutively by face-to-face questionnaires from January 2021 to December 2021. SLE patients completed questionnaires for demographic or clinical variables, the 10-cm Visual Analog Scale for pain, the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) for disease activity, the multidimensional fatigue inventory (MFI) for fatigue, the patient health questionnaire-9 (PHQ-9) for depression, the Female Sexual Function Index (FSFI) for problems, and the Short Form 12 health survey for quality of life. Independent sample t-test, Mann–Whitney U-test, Chi-square test, and forward stepwise binary logistic regression model were used to analyze these data. Results Our results showed that the prevalence of female sexual problems was 78.9% in SLE patients, which was significantly higher than the controls (56.7%; p < 0.05). The results found that having child (OR 23.04; p < 0.000), age (OR 1.11; p = 0.002), DMARDs usage (OR 0.04; p = 0.004), MFI total score (OR 1.06; p = 0.006), and disease duration (OR 1.16; p = 0.043) were the potential risk factors of female sexual problems by forward stepwise binary logistic regression. Conclusion The present study reported that female sexual problems was more common in Chinese SLE female patients compared to controls. Having child, age, DMARDs usage, fatigue, and disease duration had great impacts on female sexual problems in Chinese SLE patients. Rheumatologists and nurses should pay close attention to SLE female patients’ sexual problems, especially those having no child, older age, not using DMARDs, fatigue, or long disease duration by health education or other methods to improve their sexual problems, and ultimately improve SLE patients’ quality of life.

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Systemic lupus erythematosus and risk of sexual dysfunction: A systematic review and Meta-Analysis

Cited by 10 publications

References 43 publications

The effect of systemic lupus erythematosus on sexual function in women: an updated meta-analysis based on cross-sectional studies

The effect of systemic lupus erythematosus on sexual function in women: an updated meta-analysis based on cross-sectional studies

Factors associated with intimacy in female Taiwanese patients with systemic lupus erythematosus: a cross-sectional study

Fatigue have impact on the sexual problems in Chinese females with systemic lupus erythematosus

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