Systemic lupus erythematosus and eosinophilic fasciitis: An unusual association

Baffoni, Laura; Frisoni, M.; Maccaferri, M.; S, Ferri

doi:10.1007/bf02208164

Cited by 12 publications

(5 citation statements)

References 7 publications

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“…EF is sometimes associated with hematologic diseases, particularly with aplastic anemia (AA) (n = 19), 2 , 13 , 15 , 22 , 24 , 30 , 33 , 38 , 57 , 58 , 73 , 77 , 89 , 95 , 111 , 117 , 128 but also with T-cell lymphoma (n = 5), 27 , 36 , 65 , 72 , 83 cutaneous T-cell lymphoma (n = 1), 25 Hodgkin disease (n = 3), 84 , 90 , 98 myeloproliferative syndromes (n = 3), 61 , 75 , 85 myelomonocytic leukemia (n = 2), 75 , 85 chronic lymphocytic leukemia (n = 2), 12 , 75 multiple myeloma (n = 1), 68 and myeloblastic leukemia (n = 1), 90 and, less commonly, with solid tumors such as breast cancer (n = 5), 12 , 90 , 109 , 127 choroidal melanoma (n = 1), 125 colorectal cancer (n = 1), 94 and prostate cancer (n = 1). 90 Diffuse EF has also been reported in association with autoimmune disorders, such as Hashimoto thyroiditis (n = 6), 2 , 5 , 13 , 59 , 114 systemic lupus erythematosus (n = 4), 6 , 43 , 45 , 74 Crohn disease (n = 1), 82 Graves disease (n = 1), 114 glomerulonephritis (n = 1), 63 rheumatoid arthritis (n = 1), 81 type 1 diabetes (n = 1), 46 and autoimmune cytopenias, including autoimmune hemolytic anemia (n = 2), 5 , 44 immune thrombocytopenic purpura (n = 2), 5 , 111 amegakaryocytic thrombocyt...…”

Section: Introductionmentioning

confidence: 99%

Severe Aplastic Anemia Associated With Eosinophilic Fasciitis

Masson

Bouaziz²,

Latour

et al. 2013

Medicine

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Diffuse eosinophilic fasciitis (Shulman disease) is a rare sclerodermiform syndrome that, in most cases, resolves spontaneously or after corticosteroid therapy. It has been associated with hematologic disorders, such as aplastic anemia. The clinical features and long-term outcomes of patients with eosinophilic fasciitis and associated aplastic anemia have been poorly described. We report the cases of 4 patients with eosinophilic fasciitis and associated severe aplastic anemia. For 3 of these patients, aplastic anemia was refractory to conventional immunosuppressive therapy with antithymocyte globulin and cyclosporine. One of the patients received rituximab as a second-line therapy with significant efficacy for both the skin and hematologic symptoms. To our knowledge, this report is the first to describe rituximab used to treat eosinophilic fasciitis with associated aplastic anemia.In a literature review, we identified 19 additional cases of eosinophilic fasciitis and aplastic anemia. Compared to patients with isolated eosinophilic fasciitis, patients with eosinophilic fasciitis and associated aplastic anemia were more likely to be men (70%) and older (mean age, 56 yr; range, 18–71 yr). Corticosteroid-containing regimens improved skin symptoms in 5 (42%) of 12 cases but were ineffective in the treatment of associated aplastic anemia in all but 1 case. Aplastic anemia was profound in 13 cases (57%) and was the cause of death in 8 cases (35%). Only 5 patients (22%) achieved long-term remission (allogeneic hematopoietic stem cell transplantation: n = 2; cyclosporine-containing regimen: n = 2; high-dose corticosteroid-based regimen: n = 1).

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Section: Introductionmentioning

confidence: 99%

Severe Aplastic Anemia Associated With Eosinophilic Fasciitis

Masson

Bouaziz²,

Latour

et al. 2013

Medicine

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“…In our patient, SLE developed first, followed 3 years later by the appearance of EF. The patient reported by Morteo et al 8 also developed SLE first, which was followed 8 years later by the appearance of EF. Although in only one of the five reported cases, both disorders were concurrent, their association in the same patient suggests an immunological basis for EF, in addition to the suggested connective tissue biological basis because of its association with morphea or systemic sclerosis.…”

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confidence: 84%

“…In our patient, SLE developed first, followed 3 years later by the appearance of EF. The patient reported by Morteo et al 8 . also developed SLE first, which was followed 8 years later by the appearance of EF.…”

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confidence: 85%

Association between eosinophilic fasciitis and systemic lupus erythematosus

Kitamura

Hatamochi

Hamasaki

et al. 2007

The Journal of Dermatology

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“…In those cases, the EF sometimes occurred in patients with known SLE, 6 sometimes the EF preceded the SLE by several years, 7,8 and in other cases the discovery of both affections was concomitant. 9,10 The combination of EF with autoimmune diseases including SLE, suggests an immunological basis for the EF, which deserves to be studied further.…”

Section: Sirmentioning

confidence: 99%