Systemic lupus erythematosus and associated healthcare resource consumption in selected cities from the Russian Federation, Republic of Kazakhstan and Ukraine: the ESSENCE study

Насонов, Е. Л.; Soloviev, S; Davidson, Julie; Лила, А. М.; Togizbayev, G; Иванова, Р; Baimukhamedov, Chokan; Omarbekova, Zh; Iaremenko, O.; Gnylorybov, A.; Шевчук, С. В.; Vasylyev, Averyan; Makarova, Janina; Tariq, Luqman

doi:10.1080/13696998.2018.1499518

Cited by 6 publications

(6 citation statements)

References 17 publications

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“…4 Likewise, in the ESSENSE study, patients who experienced lupus-related flares had significantly higher rates of unplanned visits to specialists and were more often hospitalized for longer periods of time. 5 Risk factors for increased hospitalization rates and health care resource utilization for patients experiencing a flare are multifactorial but include missed appointments, elevations in biomarkers of disease activity or severity • When measured using conventional scales in clinical trials, lupus flares are associated with increased risk of health care utilization. • Current scales to measure flare frequency do not consider interpretation by the patient.…”

Section: R E S E a R C Hmentioning

confidence: 99%

Patient-Reported Lupus Flare Symptoms Are Associated with Worsened Patient Outcomes and Increased Economic Burden

Katz

Nelson

Daly

et al. 2020

JMCP

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BACKGROUND: Lupus flares significantly contribute to health resource utilization and hospitalizations. Identification of flare activity may be hindered since validated assessment scales are rarely used in clinical practice and flare severity may fall below clinician-assessed thresholds. Therefore, patient-reported outcomes of lupus flare frequency are important assessment tools for lupus management.

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Section: R E S E a R C Hmentioning

confidence: 99%

Patient-Reported Lupus Flare Symptoms Are Associated with Worsened Patient Outcomes and Increased Economic Burden

Katz

Nelson

Daly

et al. 2020

JMCP

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“…человек, а заболеваемость -0,3-1,6 случая на 100 тыс. человек среди всего населения страны [49]. Анализ показателей заболеваемости СКВ в Казахстане за 10 лет (2009-2018 гг.)…”

Section: Discussionunclassified

Features of clinical manifestations, course, outcomes and health related quality of life in patients with systemic lupus erythematosus in the Republic of Kazakhstan

Issayeva

Асеева²,

Saparbayeva

et al. 2022

Naučno-praktičeskaâ revmatologiâ

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Objective – to evaluate the features of clinical manifestations, course, outcomes and quality of life related to health in patients with systemic lupus erythematosus in the Republic of Kazakhstan.Patients and methods. The study included 102 patients with systemic lupus erythematosus (SLE) with a reliable diagnosis according to SLICC (2012). Disease activity was assessed by the SLEDAI 2K index, organ damage (IOD) by SLICC/ACR (2000). Statistical processing was carried out using SPSS 13 software (IBM Corp., USA). Variables with a parametric distribution are presented as М±SD, nonparametric – as a median (Me) [25th; 75th percentile].Results and discussion. The cohort was dominated by female patients (98%), Asians (83.33%), young patients (33.85±10.58 years) with a disease duration of 5 [2; 9] years with high (30.8%) and very high (39.2%) degree of activity (SLEDAI-2K – 17.64±8.80 points). The debut of the disease was in 18.6% of patients in adolescence, it was characterized by an unfavorable course. Clinical manifestations of the disease: skin lesions (acute active and chronic forms) (98%), joints (79.4%), non-scarring alopecia (75.5%), neuropsychiatric disorders (49%), mucous membranes (46.1%), hematological (54.9%) and immunological disorders (100%). IOD: low – in 20.6%, medium – in 59.8%, high – in 9.8% of patients, 0 – in 9.8%, Risk factors for poor outcome were in 93.1% of patients. Assessment of health-related quality of life (HRQOL) in SLE patients showed a significant decrease on all scales. Correction of the treatment program, taking into account the factors of adverse outcome (FRNI), consisted in strengthening therapy with the inclusion of genetically engineered biological drugs (GEBP).Conclusion. SLE is a socially significant disease in Kazakhstan with a high incidence rate (101%) over 10 years (2009–2018). The cohort of SLE patients is dominated by young people, females. The duration of the disease is up to 5 years with a delayed verification of the diagnosis of SLE. Organ damage is already in the onset of the disease and the presence of FRNI of the disease in 93.1% of patients, which indicates the severity of the course, which requires early diagnosis and active involvement of pathogenetic treatment, including GEBD.

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“…Распространенность заболевания во всем мире приблизилась к 50-100 случаям на 100 тысяч человек среди взрослого населения [3]. В Российской Федерации распространенность СКВ составляет 9,0-20,6 случая на 100 тысяч человек в зависимости от региона, а заболеваемость -0,3-1,6 случая на 100 тысяч человек среди всего населения страны [10]. Среди заболевших СКВ преобладают женщины молодого и среднего возраста, что по отношению к пациентам мужского пола составляет 10:1, -это преимущественно больные с легкой степенью активности заболевания в дебюте (рис.…”

Section: эпидемиологияunclassified

A Modern Approach to the Diagnosis and Management of Systemic Lupus Erythematosus

Panafidina¹,

Попкова²,

Aseeva³

et al. 2021

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Objective: Using available information on epidemiology, to analyse the impact from genetic factors and environment on development of systemic lupus erythematosus (SLE); to discuss asymptomatic and clinical periods of the disease; to assess the intensity of the disease, organ damages, comorbidities; to discuss the ways to improve SLE diagnosis and management. Key Points. The number of SLE cases has grown recently. The magnitude of clinical manifestations, cycles with remissions and aggravation make this disease one of the most difficult to diagnose, manage and assess therapy efficiency. As there are no diagnostic criteria for the disease, classification criteria are improved constantly. Despite the fact that the onset of the disease in half of patients is with low SLE intensity, later the disease progresses and affects several organs and systems. About 70% of patients failed to have a long-lasting remission; therefore, therapy protocols should be improved and should include immunosuppression and biological therapy. Conclusion. One of the burning issues in the modern rheumatology is lack of methods for early diagnosis and prognosis of the disease. Development and practical implementation of therapy recommendations can improve the therapy results and disease outcome. Keywords: systemic lupus erythematosus, epidemiology, criteria of the European League Against Rheumatism/American College of Radiology 2019, intensity, lupus nephritis.

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Systemic lupus erythematosus and associated healthcare resource consumption in selected cities from the Russian Federation, Republic of Kazakhstan and Ukraine: the ESSENCE study

Abstract: Specialist visits are the most frequently consumed SLE-related healthcare recourse in the Commonwealth of Independent States (CIS) countries. A relapsing-remitting SLE profile and the occurrence of flares significantly raise healthcare resource consumption.

Cited by 6 publications

References 17 publications

Patient-Reported Lupus Flare Symptoms Are Associated with Worsened Patient Outcomes and Increased Economic Burden

Patient-Reported Lupus Flare Symptoms Are Associated with Worsened Patient Outcomes and Increased Economic Burden

Features of clinical manifestations, course, outcomes and health related quality of life in patients with systemic lupus erythematosus in the Republic of Kazakhstan

A Modern Approach to the Diagnosis and Management of Systemic Lupus Erythematosus

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