Systemic Lupus Erythematosus: An Overview of the Disease Pathology and Its Management

Ali, Asad; Sayyed, Zohaib; Ameer, Muhammad Atif; Arif, Abdul Wahab; F, Kiran; Iftikhar, Ayesha; Iftikhar, Waleed; Ahmad, Malik Qistas; Malik, Muhammad Bilal; Kumar, Vijay; Dass, Arjan; Sami, Shahzad Ahmed; Sapna, Fnu; Waqas, Neha

doi:10.7759/cureus.3288

Cited by 20 publications

(27 citation statements)

References 27 publications

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“…The impact of the disease on the everyday life of patients is significant. Nevertheless, in general, we may state that thanks to an efficient therapy and sufficiently timely diagnostics the prognosis of patients with SLE [21] has lately improved and the impact of the disease on a patient has been mitigated. SLE is a chronic, progressive disease that leads to irreversible organ changes when activity persists.…”

Section: Discussionmentioning

confidence: 99%

Living with Systemic Lupus Erythematosus: A Profile of Young Female Patients

Macejová

Gecková

Husárová

et al. 2020

IJERPH

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The aim is to describe a profile of systemic lupus erythematosus (SLE) patient (socio-demographic data, course of disease, health status, and health care utilization, SLE impact on their life, SLE awareness) and to explore the association of patient’s perspective with clinical indicators. Adult patients diagnosed by SLE were recruited in outpatient clinics (n = 76, 88% female, data collected in 2012–2016, Slovakia). The association of patients’ perspective (SLE status, health complaints during remission, SLE impact, hospitalizations) with clinical activity (European Consensus Lupus Activity Measurement Index—ECLAM) and inflammatory marker (erythrocyte sedimentation rate—ESR) was assessed by t-test for independent variables and one-way ANOVA. Almost 17.9% of patients reported relapse. During remission, they mostly suffered fatigue and pain. Nearly all patients were on chronic pharmacological treatment. Most of the patients assessed SLE impact on their life as restrictive (56.9%) or very restrictive (23.1%). The most frequent source of information was their physician, and 67.2% reported that they have sufficient information about the disease and its treatment. Only the association of SLE status and hospitalization with clinical activity (ECLAM) and inflammatory marker (ESR) were confirmed. With recent improvements in diagnostics and therapy options, the prognosis for patients with SLE has improved. Nevertheless, the impact of this disease on all areas of a patient’s life is extensive.

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Section: Discussionmentioning

confidence: 99%

Living with Systemic Lupus Erythematosus: A Profile of Young Female Patients

Macejová

Gecková

Husárová

et al. 2020

IJERPH

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“…Impaired DNA repair may induce an autoimmune response in susceptible individuals. DNA damage can be produced by endogenous factors involving reactive oxygen species, or indirectly during base excision repair (BER) pathway for DNA damage, or exogenous factors as chemicals, ionizing radiation, and ultraviolet (UV) irradiation [9].…”

Section: Introductionmentioning

confidence: 99%

Gene XRCC1Arg399Gln polymorphism and its genotype variations: clinical associations in Egyptian systemic lupus erythematosus patients

Mortada

Zidan

Abdelsalam

et al. 2020

Egypt Rheumatol Rehabil

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Background Impaired deoxyribonucleic acid (DNA) repair may induce an autoimmune response in susceptible individuals. The association between DNA repair gene XRCC1 Arg399Gln gene polymorphism and susceptibility of systemic lupus erythematosus (SLE) is controversial. This study aimed to detect the association of XRCC1 Arg399Gln gene polymorphism with SLE and its clinical manifestations in the Egyptian population. Results A significant association was found between weight loss and genotype GG (P = 0.048); however, genotype AG was significantly associated with high serum creatinine and low C3 level (P = 0.039, P = 0.009, respectively). On the other hand, there was no significant difference between patients and controls regarding genotype and allele frequency. Conclusions An association was found between weight loss, high serum creatinine, and low C3 level and genotypes of XRCC1 Arg 399 Gln gene polymorphism.

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“…The systemic lupus erythematosus (SLE) is a heterogeneous chronic autoimmune disease known as a multisystem inflammatory disease. 1,2 SLE is characterized by dysregulation in the innate and adaptive immune system and high-level production of autoantibodies. 3 The patients with SLE may represent various clinical features ranging from skin manifestations to lifethreatening renal involvement.…”

Section: Introductionmentioning

confidence: 99%

Three functional variants in the NLRP3 gene are associated with susceptibility and clinical characteristics of systemic lupus erythematosus

Ehtesham

Rafie

Esmaeilzadeh

et al. 2021

Lupus

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Objective Nod-like receptor pyrin domain containing 3 ( NLRP3) gene encodes an intracellular receptor whose dysregulation in systemic lupus erythematosus (SLE) has been reported in multiple studies. Activation of NLRP3 inflammasome leads to the induction of inflammatory response via cleaving and producing of specific cytokines. In the present study, we assessed the possible association between three functional polymorphisms in this gene and SLE risk in the Iranian population. These variants include two gain of function (rs4612666 and rs10754558) and one loss of function (rs6672995) which are correlated with modulation of expression of NLRP3. Methods A case-control study involving 110 SLE patients and 116 control subjects was undertaken to estimate the frequency of rs4612666, rs10754558, and rs6672995 genotypes using real-time PCR high resolution melting method (HRM). Results Our findings revealed significant associations between GG genotype and G allele of rs10754558 with increased risk of SLE (OR for GG genotype= 2.82; 95%CI [1.45–5.46]/OR for G allele= 1.97; 95%CI [1.36–2.87]). Although, no significant associations were recognized between allele and genotype frequencies of rs4612666 and rs6672995 polymorphisms with SLE risk ( P > 0.05). Also, our analysis revealed that the C allele in rs4612666 and G allele in rs10754558 was correlated with the severity of disease activity (P < 0.001). Moreover, these common variants were associated with lower age of onset and some clinical symptoms in the patient group, such as skin manifestation, neurological symptom and, renal involvement (P < 0.05). Conclusion This study demonstrates a substantial association between NLRP3 polymorphisms with increased risk, clinical symptoms, and the severity of disease activity of SLE.

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Systemic Lupus Erythematosus: An Overview of the Disease Pathology and Its Management

Cited by 20 publications

References 27 publications

Living with Systemic Lupus Erythematosus: A Profile of Young Female Patients

Living with Systemic Lupus Erythematosus: A Profile of Young Female Patients

Gene XRCC1Arg399Gln polymorphism and its genotype variations: clinical associations in Egyptian systemic lupus erythematosus patients

Three functional variants in the NLRP3 gene are associated with susceptibility and clinical characteristics of systemic lupus erythematosus

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