Systemic lupus erythematosus: a clinical update

Connelly, Kathryn; Morand, Eric Francis

doi:10.1111/imj.15448

Cited by 9 publications

(3 citation statements)

References 43 publications

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“…Anti-phospholipid antibodies are found in 29–46% of SLE patients, and up to 50% of them may have pregnancy morbidity or arterial or venous thrombosis. [ 102 ]. The condition has a hereditary component, with 24–35 percent concordance in monozygotic twins and 2–5% in dizygotic twins.…”

Section: T1dmand Autoimmune Endocrine Pathologymentioning

confidence: 99%

Type 1 Diabetes Mellitus and Autoimmune Diseases: A Critical Review of the Association and the Application of Personalized Medicine

Popoviciu

Kaka²,

Sethi

et al. 2023

JPM

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Type 1 Diabetes Mellitus (T1DM) is a common hyperglycemic disease characterized by the autoimmune destruction of insulin-producing beta cells of the pancreas. Various attempts have been made to understand the complex interplay of genetic and environmental factors which lead to the development of the autoimmune response in an individual. T1DM is frequently associated with other autoimmune illnesses, the most common being autoimmune thyroid disorders affecting more than 90% of people with T1D and autoimmune disorders. Antithyroid antibodies are present in around 20% of children with T1D at the start of the illness and are more frequent in girls. Patients with T1DM often have various other co-existing multi-system autoimmune disorders including but not limited to thyroid diseases, parathyroid diseases, celiac disease, vitiligo, gastritis, skin diseases, and rheumatic diseases. It is a consistent observation in clinics that T1DM patients have other autoimmune disorders which in turn affect their prognosis. Concomitant autoimmune illness might affect diabetes care and manifest itself clinically in a variety of ways. A thorough understanding of the complex pathogenesis of this modern-day epidemic and its association with other autoimmune disorders has been attempted in this review in order to delineate the measures to prevent the development of these conditions and limit the morbidity of the afflicted individuals as well. The measures including antibody screening in susceptible individuals, early identification and management of other autoimmune disorders, and adoption of personalized medicine can significantly enhance the quality of life of these patients. Personalized medicine has recently gained favor in the scientific, medical, and public domains, and is frequently heralded as the future paradigm of healthcare delivery. With the evolution of the ‘omics’, the individualization of therapy is not only closer to reality but also the need of the hour.

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Section: T1dmand Autoimmune Endocrine Pathologymentioning

confidence: 99%

Type 1 Diabetes Mellitus and Autoimmune Diseases: A Critical Review of the Association and the Application of Personalized Medicine

Popoviciu

Kaka²,

Sethi

et al. 2023

JPM

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“…The current study is consistent with prior research findings indicating that SLE can be present at any age (9) . it is most frequently diagnosed between ages 15 and 45 (10) .…”

Section: Discussionmentioning

confidence: 99%

Study on Some Parameters and Anti-Rubella Igg in A Sample of Systemic Lupus Erythematosus Patients

Jasim¹,

Salloom²

2022

The Egyptian Journal of Hospital Medicine

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Background: Systemic lupus erythematosus (SLE) is an autoimmune syndrome causing both organ and cell damage done by tissue-binding autoantibodies and immune complexes. Skin, joints, kidneys, lungs, and the neurological system can all be affected by this condition. Viral infections are main environmental variables in the pathogenesis of SLE, and they can cause illness initiation and recurrence, as well as modify clinical phenotypes. Objective: The aim of this study was to measure levels of anti-rubella virus IgG in serum of Iraqi patients with SLE disease and to measure the levels of some markers including S. creatinine, blood urea, aspartate transaminase (AST), alanine aminotransferase (ALT), and the reasons for their elevation in serum of patients. Materials and Methods: This study was conducted in Baghdad Teaching Hospital and Typical Rheumatology Unit through the period from October 2021 to January 2022. 103 Iraqi patients with SLE disease and 50 healthy Iraqi individuals were included as control group Blood samples were collected and the anti-rubella IgG for all subjects (for 57 patients and 34 control) was measured by the sandwich enzyme-linked immune-sorbent assay technology. Serum creatinine, blood urea, AST and ALT were measured using the automated method. Results: Anti-Rubella IgG, B. urea, S. creatinine, AST and ALT were significantly higher in patients' group compared to control group. While, there was non-significant difference regarding age between studied groups. Conclusion: Anti rubella virus IgG and some parameter can be used as markers for SLE disease activity.

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“…To date, the management of SLE has moved from conventional treatments to biological treatments to decrease the risk of progressive irreversible damage accrual and increased mortality in patients with this chronic disease [99]. Immunomodulation and immunosuppressive state are being considered for SLE therapeutic approaches [100,101]. In our results, the augmented IL-10 secretion from C. glabrata β-glucans stimulated-dendritic cells may be used and adapted for the biological therapies in SLE.…”

Section: Expression Of T Cells From Splenocytes and Lymph Node Cells ...mentioning

confidence: 78%

Effect of candida glabrata ?-glucans on immunosuppressive properties of dendritic cells

Tummamunkong

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?-glucan is a polysaccharide and consists of the backbone of ?-(1, 3)-glucan and/or ?-(1, 6)-glucan structures. ?-glucans are extracted from the cell wall of Candida sp, including Candida glabrata. Interestingly, the biological activity of Candida ?-glucan has been represented as a stimulator in the mechanism of immune responses. Dendritic cells are powerful antigen-presenting cells that play a significant role in both innate and adaptive immunity. In the present study, we evaluated the effect of C. glabrata ?-glucans on dendritic cell (DC) immunologic responses. Firstly, bone marrow-derived DCs (BMDCs) were induced with C. glabrata ?-glucans in a dose-dependent manner. The expression of CD80, CD86, CD40, and MHCII in BMDC markedly increased after stimulation. C. glabrata ?-glucan-stimulated BMDCs significantly enhanced the production of immunosuppressive cytokine, interleukin-10 (IL-10). Secondly, BMDC after stimulation could promote a high level of IL-10 secretion by T cells. IL-10 plays a critical role in limiting the inflammatory immune response and its ability to mediate the immunosuppressive response. Furthermore, the level of serum anti-(double-stranded)-DNA antibodies promisingly decreased in Fcgr2b-/- lupus-prone mice after C. glabrata ?-glucans immunization in an in vivo experiment. Our results imply that C. glabrata ?-glucans have the induction of immunosuppressive responses in dendritic cells and T cells and may be beneficial for the amelioration of lupus disease.

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Systemic lupus erythematosus: a clinical update

Cited by 9 publications

References 43 publications

Type 1 Diabetes Mellitus and Autoimmune Diseases: A Critical Review of the Association and the Application of Personalized Medicine

Type 1 Diabetes Mellitus and Autoimmune Diseases: A Critical Review of the Association and the Application of Personalized Medicine

Study on Some Parameters and Anti-Rubella Igg in A Sample of Systemic Lupus Erythematosus Patients

Effect of candida glabrata ?-glucans on immunosuppressive properties of dendritic cells

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