Systemic Lupus Erythematosus

Silverman, Earl D.; Eddy, Allison A.

doi:10.1016/b978-1-4160-6581-4.10021-4

Cited by 28 publications

(26 citation statements)

References 565 publications

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“…Patients diagnosed with SLE in adulthood may be less likely to have a family history of SLE, leading to later consideration of this disease in a diagnostic evaluation. As documented in previous studies, thyroid disease was also common in relatives of our pediatric subjects with SLE (15%), likely because thyroid disease is a relatively common autoimmune disease in the general population [3,5,9]. …”

Section: Discussionsupporting

confidence: 61%

“…This cohort of subjects seems to accurately represent pediatric SLE patients overall, with a female predominance of 83%, and a female to male ratio of approximately five to one [8,9]. Most patients in this cohort had severe SLE (67%), as defined by treatment course required.…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 15% of SLE patients are diagnosed in childhood [7]. Most pediatric studies demonstrate a female to male ratio of two to five females per one male affected with childhood SLE, in contrast to nine females per one male in adult SLE patients [8,9]. Approximately 10% of SLE patients have a relative that also has SLE, and first-degree relatives of SLE patients have an increased probability of having a non -SLE autoimmune disease in comparison to the general population [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus

et al. 2012

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BackgroundA high prevalence of autoimmune disease (AD) has been documented in relatives of adult patients with systemic lupus erythematosus (SLE). However, data on familial inheritance patterns in pediatric SLE patients is scarce.FindingsThe charts of 69 patients with pediatric-onset SLE were reviewed retrospectively. The primary aim was to describe the prevalence and types of AD in relatives of children with SLE. The secondary aims were: 1) to compare severity of SLE in children with and without relatives affected by AD, and 2) to evaluate the impact of baseline demographics on severity of SLE in subjects. At diagnosis, 42% of subjects had one or more first, second, or third degree relative(s) with AD; and 32% of subjects had one or more first degree relative(s) with AD. The most common diseases in relatives of children with SLE were SLE (21%) and thyroid disease (15%). Subjects with no family history of AD were more likely to have severe SLE. SLE severity in subjects did not differ by gender. Children presenting with SLE at an earlier age were found to have more severe disease.ConclusionsThis study demonstrated a high prevalence of AD in families of children with SLE, although a family history of AD did not correlate with more severe SLE in subjects. Future larger studies are necessary to elucidate patterns of familial inheritance and baseline patient characteristics that may affect severity of disease in pediatric SLE.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus

et al. 2012

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“…There is significant female dominance in the postpubertal age group, which is less pronounced in younger age groups. It presents before the age of 18 in between 15% and 20% of individuals,3 with pulmonary involvement occurring in up to 40% within the first year of diagnosis, doubling that at any point in the disease course 4. The associated respiratory complications in JSLE can be categorised into acute and chronic (see table 1).…”

Section: Juvenile Systemic Lupus Erythematosusmentioning

confidence: 99%

Respiratory complications of the rheumatological diseases in childhood

2016

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Pleuropulmonary manifestations of rheumatological diseases are rare in children but pose a significant risk to overall morbidity and mortality. We have reviewed the literature to provide an overview of the respiratory complications of the commonest rheumatological diseases to occur in children (juvenile systemic lupus erythematosus, scleroderma, juvenile dermatomyositis, mixed connective tissue disease, granulomatosis with polyangitis and juvenile idiopathic arthritis). Pulmonary function testing in these patients can be used to refine the differential diagnosis and establish disease severity, but also has a role in ongoing monitoring for respiratory complications. Early detection of pulmonary involvement allows for prompt and targeted therapies to achieve the best outcome for the child. This is best achieved with joint specialist paediatric rheumatology and respiratory reviews in a multidisciplinary setting.

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“…On the contrary, prevalence of chorea was slightly higher: we recorded it in 6% of our SLE patients (instead of 0-5% [4]).…”

Section: Discussionmentioning

confidence: 78%

Chorea, a little-known manifestation in systemic lupus erythematosus: short literature review and four case reports

et al. 2013

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Chorea is a movement disorder that may be found in children due to several causes. Here we focus especially on Systemic Lupus Erythematosus associated chorea. First we outline its epidemiology, hypothesized pathogenesis, clinical presentation and treatment, then we report four significant clinical cases, which represent well the extreme variability of set of symptoms that may accompany lupus chorea. Our experience, according to literature, suggests that choreic movements in a child should alert the pediatrician and lead him to investigate a potential neurological involvement of Systemic Lupus Erythematosus.

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Systemic Lupus Erythematosus

Cited by 28 publications

References 565 publications

Patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus

Patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus

Respiratory complications of the rheumatological diseases in childhood

Chorea, a little-known manifestation in systemic lupus erythematosus: short literature review and four case reports

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