“…However, this equilibrium can be lost by impairment of any of these systems. In this regard, NF-κB activation by low-grade inflammation can be especially relevant as it has been reported in virtually all chronic age-related diseases, from metabolic disturbances, like diabetes mellitus, obesity, and the metabolic syndrome, to neurodegenerative, musculoskeletal, renal, cardiovascular, pulmonary, intestinal, and even behavioural diseases (Rosa, Judas, Lopes, & Mendes, 2008;Scarpellini & Tack, 2012;Speer, Upton, Semple, & McKune, 2018;Zhu, Armstrong, Tchkonia, & Kirkland, 2014). Interestingly, ageing and age-related diseases have also been associated with impaired circadian expression of core-clock genes and CCGs and impaired SIRT1 activity (Kondratov, Kondratova, Gorbacheva, Vykhovanets, & Antoch, 2006;Musiek et al, 2018;Wang et al, 2018).…”