Systemic lithium reabsorption from lithium-chloride-coated heat and moisture exchangers

Rosi, R; Buscalferri, A.; Monfregola, M. R.; Criscuolo, S.; Pra, P. Dal; Stanca, A

doi:10.1007/bf01712336

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…One study has shown that lithium can be absorbed into the body in toxic amounts. This may present a greater risk to small children (30). The HCHF adds a bacterial filter between the insert and the source of inspired gas.…”

Section: Humidification Backgroundmentioning

confidence: 99%

Care of the Child with a Chronic Tracheostomy

Jm¹,

Davis²,

Albamonte-Petrick³

et al. 2000

Am J Respir Crit Care Med

181

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Children with a chronic tracheostomy constitute an important subgroup of children who are at risk for potentially devastating airway compromise. There have been no standards published for their care and disappointingly little research. The Pediatric Assembly of the American Thoracic Society funded a working group with input from the disciplines of pediatric pulmonology, pediatric surgery, pediatric otolaryngology, respiratory therapy, speech pathology, and nursing to develop a consensus statement regarding their care. This statement has been reviewed and revised by the committee members, who concur with its recommendations. Many of the recommendations are by consensus in the absence of scientific data, and suggestions are made for areas of research.

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Section: Humidification Backgroundmentioning

confidence: 99%

Care of the Child with a Chronic Tracheostomy

Jm¹,

Davis²,

Albamonte-Petrick³

et al. 2000

Am J Respir Crit Care Med

181

View full text Add to dashboard Cite

show abstract

“…These include an increase in the work of breathing, 5 airway obstruction [6][7][8] and lithium toxicity. 9 Airway obstruction develops when moisture, typically patient secretions, nebulized drugs 10 or moisture from within the circle circuit, occludes the pores within the HMEF, leading to a significant increase in resistance. Fortunately, moisture levels typically seen in routine use do not result in obstruction.…”

mentioning

confidence: 99%

Performance of breathing filters under wet conditions: a laboratory evaluation † †Presented in part to the European Society of Anaesthesia, Glasgow, May 2003.

Turnbull

Fisher

Mills

et al. 2005

British Journal of Anaesthesia

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The ideal HMEF for use during general anaesthesia should prevent the passage of viral, bacterial and prion material, should provide this filtration performance even under wet conditions, should supplement humidification of the inspired air and anaesthetic gases and should not increase respiratory work. We have identified large variations in HMEF performance under wet conditions. Users should be aware of performance variation in HMEFs and use a filter suited to the intended application.

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“…A tolerabilidade é um aspecto especialmente preocupante, pois as crianças são mais susceptíveis aos efeitos colaterais que adultos (Rosi et al, 1995, Campbell et al, 1991. Dessa forma, entende-se a obtenção de valor máximo dos exames de litemia menor em crianças que adolescentes, demonstrando esse cuidado no limite da faixa terapêutica utilizada para as crianças (Tabela 10: valor máximo em crianças = 1,1 mEq/L, e valor máximo em adolescentes = 1,5 mEq/L).…”

Section: Ii5 Discussãounclassified

Carbonato de lítio: utilização da espectrofotometria de absorção atômica em bioequivalência e perfil de uso na pediatria.

Guilherme¹

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The ideal of this thesis is to benefit patients that use lithium carbonate, through two studies: (1) comparison of the relative bioavailability/bioequivalence of two distinct lithium formulations; and (2) investigation of lithium use in children and adolescents. In order to analyze the bioequivalence, healthy volunteers (N=24), of both genders, were submitted to treatments of two lithium carbonate formulations (300 mg): test-Neurolithium and reference-Carbolitium. After a single dose administration of each formulation, plasma samples were collected to quantify lithium, using atomic absorption spectrophotometry. The method was developed specially to this study and it showed 0,07mg/L quantification limit. The geometric media and the 90% confiance interval test/reference was 104,77 (98,60-111,33%) to Cmax and 101,99 (96,81-107,44%) to ASClast. Based on FDA and ANVISA parameters, we concluded that Neurolithium is bioequivalent to Carbolitium. This thesis yearned for favoring patients that need lithium prescription through scientific evidences that assure the commercialization of a qualified formulation and make possible the register of a generic medication with low cost. Since information regarding the safety and effectiveness of lithium in children under 12 years of age is not available, its use in such patients is not recommended at this time. Therefore, the second study has investigated the use of lithium in pediatric patients, subdivided in two groups: under and over 12 years old. Patients that received lithium carbonate prescription inside the "Hospital de Clínicas" of Unicamp, in Campinas-SP, between 2000 January and 2006 December, were identified. Only clinical register of patients (N=77) under 21 years old, were selected and revised retroactively. We have noticed fewer doses administrations in patients under 12 years old. Seric levels and side effects indexes were not different between both groups. Patients under 12 years old showed reason for lithium prescription (aggressiveness) and indexes effectiveness per patient (71%) different from patients over 12 years old (humor oscillation; 83%). Since indexes effectiveness of both groups were in accordance with those found in literature and there was no difference in side effects number per patient, we concluded that the use of lithium in patients under 12 years old is feasible. Therefore, this thesis gives information regarding the use of lithium, which has grown without sufficient evidences supporting the effectiveness e safety in this pediatric population.

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Systemic lithium reabsorption from lithium-chloride-coated heat and moisture exchangers

Cited by 6 publications

References 12 publications

Care of the Child with a Chronic Tracheostomy

Care of the Child with a Chronic Tracheostomy

Performance of breathing filters under wet conditions: a laboratory evaluation † †Presented in part to the European Society of Anaesthesia, Glasgow, May 2003.

Carbonato de lítio: utilização da espectrofotometria de absorção atômica em bioequivalência e perfil de uso na pediatria.

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