Systemic Listeria monocytogenes infection in a 2-year-old immunocompetent child

Lobotková, Denisa; Dická, E.; Rolný, V.; Stanković, Ivana; Čižnár, Peter

doi:10.1007/s15010-014-0655-8

Cited by 8 publications

(9 citation statements)

References 20 publications

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“…Like other causes of bacteremia, listeriosis can cause fulminant disease, presenting with severe systemic illness leading to distributive shock and multiorgan failure, usually in the immunocompromised. Although there are several case reports of Listeria meningoencephalitis in immunocompetent hosts, the presence of sepsis secondary to Listeria in otherwise healthy individuals, as in our patient, is extremely uncommon . Only the two patients reported by Von Rotz et al.…”

Section: Discussionmentioning

confidence: 49%

A life‐devastating cause of gastroenteritis in an immunocompetent host: was it suspected?

Wahab

Chaudhary

Ahmad

et al. 2017

Clinical Case Reports

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Section: Discussionmentioning

confidence: 49%

A life‐devastating cause of gastroenteritis in an immunocompetent host: was it suspected?

Wahab

Chaudhary

Ahmad

et al. 2017

Clinical Case Reports

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“…In this study, the peripheral blood leukocytes of 3 patients (Patient 2, 7, 8) were close to normal yet the levels of neutrophils and CRP were increased in all cases. Previous reports showed that typical monocyte predominance was different from other general forms of meningitis (12,13), whereas neutrophilic predominance has been reported in other studies (10,11,(14)(15)(16). These findings may be due to the increases in monocytes due to the presence of L. monocytogenes which is a facultative intracellular pathogen.…”

Section: Discussionmentioning

confidence: 70%

A Retrospective Study of Rare Listeria Meningoencephalitis in Immunocompetent Children in China

Dou

et al. 2022

Front. Neurol.

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ObjectivesListeria meningoencephalitis (LMM) is very rare in healthy children. We aimed to assess the clinical features, differential diagnosis, treatment options, and outcomes of LMM in immunocompetent children through a retrospective study.MethodsThe clinical symptoms, laboratory findings, imaging features, antibiotic use, and metagenomic next-generation sequencing (mNGS) results of the cerebrospinal fluid (CSF) were obtained from immunocompetent children who were diagnosed with LMM and admitted to the Xi'an Children's Hospital from May 2018 to July 2020.ResultsThe data from 8 immunocompetent children were retrospectively analyzed in this study. The cohort included data from 5 males and 3 females who were aged from 1 year and 7 months to 16 years and 6 months. A total of 4 patients had chilled food before onset. The complications included hyponatremia (3/8), hydrocephalus (2/8), and hemophagocytic syndrome (1/8). In total, 8 patients were diagnosed with Listeria monocytogenes by positive CSF culture or mNGS results. The positive rate of CSF culture was 62.5% (5/8). A total of 5 patients conducted CSF mNGS, and the results of the mNGS were positive in 4 patients (80%, 4/5) and suspected in 1 patient. A total of 7 patients changed their therapeutic regimen to combined antibacterial therapies that included linezolid and meropenem (5/8), or ampicillin and meropenem (2/8). A total of 5 patients had favorable outcomes (Glasgow Outcome Scale, GOSE = 5) while two patients had unfavorable outcomes (GOSE = 1) and were complicated with hyponatremia and hydrocephalus.ConclusionsListeria meningoencephalitis (LMM) can occur in children with normal immune function and is commonly mistaken for other central nervous system infections. L. monocytogenes can be quickly and accurately detected by mNGS. Hyponatremia and hydrocephalus may indicate unfavorable outcomes.

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“…Despite most non-perinatal listeriosis cases are people with comorbid conditions, the study also indicated that neurological listeriosis can affect people without (known) underlying diseases and very young immunocompetent children. Other recent case reports also revealed that listeriosis can affect very young children and that an appropriate treatment at the onset, based on intravenous ampicillin in the first line therapy, can avoid the spread of the infection in the patient [ 10 – 13 ].…”

Section: Discussionmentioning

confidence: 99%

Comorbidities and factors associated with central nervous system infections and death in non-perinatal listeriosis: a clinical case series

et al. 2016

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BackgroundListeriosis is a rare disease caused by the bacterium Listeria monocytogenes and mainly affects at risk people. Listeriosis can lead to sepsis, central nervous system (CNS) infections and death. The objectives of this study were to describe and quantify comorbidities and neurological sequelae underlying non-perinatal listeriosis cases and to describe the factors associated with death and CNS infections in non-perinatal listeriosis.MethodsWe retrospectively collected clinical data through computerized, paper or microfilmed medical records in two Belgian university hospitals. Logistic regression models and likelihood ratio tests allowed identifying factors associated with death and CNS infections.ResultsSixty-four cases of non-perinatal listeriosis were included in the clinical case series and 84 % were affected by at least one comorbid condition. The main comorbidities were cancer, renal and severe cardio-vascular diseases. Twenty-nine patients (45 %) suffered from a CNS infection and 14 patients (22 %) died during hospitalization, among whom six (43 %) had a CNS involvement. Among surviving patients, eleven suffered from neurological sequelae (22 %) at hospital discharge; all had CNS infection. Five of these patients (45 %) still suffered of their neurological sequelae after a median follow-up of one year (range: 0.08–19). The factor associated with death during the hospitalization was the presence of a severe cardiovascular disease (OR = 4.72, p = 0.015). Two factors inversely related with CNS infections were antibiotic monotherapy (OR = 0.28, p = 0.04) and the presence of renal disease (OR = 0.18, p = 0.02).ConclusionsIn a public health context these results could be a starting point for future burden of listeriosis studies taking into account comorbidity.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-016-1602-3) contains supplementary material, which is available to authorized users.

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Systemic Listeria monocytogenes infection in a 2-year-old immunocompetent child

Cited by 8 publications

References 20 publications

A life‐devastating cause of gastroenteritis in an immunocompetent host: was it suspected?

A life‐devastating cause of gastroenteritis in an immunocompetent host: was it suspected?

A Retrospective Study of Rare Listeria Meningoencephalitis in Immunocompetent Children in China

Comorbidities and factors associated with central nervous system infections and death in non-perinatal listeriosis: a clinical case series

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