Systemic lipofuscinosis associated with a lesion of autophagic vacuolar myopathy in the diaphragmatic muscle of a cow

Vascular smooth muscle lipofuscinosis occurring predominantly in veins of a cynomolgus monkey (<i>Macaca fascicularis</i>)

“…Deposition in the smooth muscles has been reported as part of systemic lipofuscinosis in a non-human primate and other species [5,7,8]. In human, smooth muscle lipofuscinosis has been reported as brown bowel syndrome, a rare condition characterized by deposition in the intestinal smooth muscles.…”

“…It occurs in a variety of tissues and cell types, such as neurons, myocardiocytes, hepatocytes, skeletal muscle and smooth muscle [ 6 , 10 ]. Lipofuscin deposition in smooth muscle are reported in some cases, such as brown bowel syndrome in humans, brown gut in dogs, and ceroid-lipofuscinosis, an inherited lysosomal storage disease, in several animal species [ 2 , 3 , 5 , 7 , 8 , 9 , 11 ]. To our knowledge, however, there has been no report describing vascular smooth muscle lipofuscinosis occurring predominantly in the veins of primates including humans.…”

“…In non-human primates, a few case of lipofuscinosis has been reported, however they are neuronal ceroid-lipofuscinosis mainly in central nervous system [ 1 , 5 ]. Deposition in the smooth muscles has been reported as part of systemic lipofuscinosis in a non-human primate and other species [ 5 , 7 , 8 ]. In human, smooth muscle lipofuscinosis has been reported as brown bowel syndrome, a rare condition characterized by deposition in the intestinal smooth muscles.…”