Systemic lidocaine and human somatosensoryevoked potentials during sufentanil-isoflurane anaesthesia

Schubert, Armin; Licina, Michael G.; Glaze, Gary M.; Paranandi, Lata

doi:10.1007/bf03008320

Cited by 27 publications

(9 citation statements)

References 31 publications

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“…In addition, lidocaine has been shown to possess antianflammatory properties and analgesic properties [16,21,26,27]. While lidocaine has been shown to depress the amplitude and prolong the latency of SSEPs, the SSEP waveforms were preserved and interpretable when used as part of a narcotic based anesthetic [56].…”

Section: Lidocainementioning

confidence: 99%

Current approach on spinal cord monitoring: the point of view of the neurologist, the anesthesiologist and the spine surgeon

2007

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Optimal outcome in spine surgery is dependent of the coordination of efforts by the surgeon, anesthesiologist, and neurophysiologist. This is perhaps best illustrated by the rising use of intraoperative spinal cord monitoring for complex spine surgery. The challenges presented by neurophysiologic monitoring, in particular the use of somatosensory and motor evoked potentials, requires an understanding by each member for the team of the proposed operative procedure as well as an ability to help differentiate clinically important signal changes from false positive changes. Surgical, anesthetic, and monitoring issues need to be addressed when relying on this form of monitoring to reduce the potential of negative outcomes in spine surgery. This article provides a practical overview from the perspective of the neurophysiologist, the anesthesiologist, and the surgeon on the requirements which must be understood by these participants in order to successfully contribute to a positive outcome when a patient is undergoing complex spine surgery.

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Section: Lidocainementioning

confidence: 99%

Current approach on spinal cord monitoring: the point of view of the neurologist, the anesthesiologist and the spine surgeon

2007

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“…Local anesthetic techniques included epidural, incisional line block, intraperitoneal (IP) block, or a combination of these techniques; six cats did not receive any local anesthetics. Lidocaine (1 mg/kg) was administered by the intravenous route in two cats during surgery due to high sympathetic tone and surgical stimulation [27]. Postoperative pain was managed using a constant rate infusion (CRI) of opioid, either fentanyl (n=22) or remifentanil (n=3), followed by buccal or intravenous buprenorphine.…”

Section: Resultsmentioning

confidence: 99%

A retrospective study of anesthesia for subcutaneous ureteral bypass placement in cats: 27 cases

Luca

Monteiro

Dunn

et al. 2017

The Journal of Veterinary Medical Science

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The goals of this retrospective clinical case series study were to describe the management of anesthesia, and to report perioperative complications in cats undergoing subcutaneous ureteral bypass (SUB) placement due to ureteral obstruction. Medical records of client-owned cats with ureteral obstruction and anesthetized for SUB placement between 2012 and 2015 in a veterinary teaching hospital were reviewed. Twenty-seven cases were identified. Duration of anesthesia and surgery (mean ± standard deviation) were 215 ± 42 min and 148 ± 36 min, respectively. Hypothermia was the most common intraoperative complication. Hypotension, hypocapnia, hypertension and bradycardia were also frequently observed. Out of 22 cats who experienced intraoperative hypotension, 17 received inotropes and vasopressors. There was a significant decrease in creatinine (P=0.008) and total solids (P=0.007) after SUB placement when compared with baseline values. Postoperative complications included pain, anorexia, nausea, hypertension, and urinary tract-related problems. No death occurred in the postoperative period. Successful management of anesthesia for SUB placement involves rigorous anesthetic monitoring and immediate treatment of complications. Perioperative complications appear to be common. This study could not identify risk factors associated with this procedure.

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“…8 Another 16 patients observational study found decreased amplitudes and prolonged latencies of SEPs after continuous infusion of lidocaine at 4 mg/kg/h followed by intraoperative injection of lidocaine at 3 mg/kg. 9 However, contrary to these findings, one retrospective study and one randomized crossover study have suggested that continuous infusion of 1-1.5 mg/kg/h lidocaine during surgery has no effect on SEPs and MEPs. 10,11 Whether lidocaine influences intraoperative electrophysiological monitoring, whether its effects on electrophysiological monitoring are related to drug concentration, and whether electrophysiological monitoring can accurately reflect the integrity of nerve functions under anaesthesia are still unclear, and further studies are necessary.…”

Section: Introductionmentioning

confidence: 91%

“…Journal of Pain Research 2022:15 294 believe that lidocaine can affect cell electrical activity and thus interfere with electrophysiological monitoring. In the study of Schubert et al, 9 intravenous lidocaine 3 mg/kg bolus followed by infusion at 4 mg/kg/h was injected into 16 patients undergoing abdominal or orthopaedic surgery under sufentanil-based anaesthesia, to observe its effects on SEPs. The plasma-drug concentrations of lidocaine at different time points after administration were measured.…”

Section: Dovepressmentioning

confidence: 99%

Effects of Lidocaine on Motor-Evoked Potentials and Somatosensory-Evoked Potentials in Patients Undergoing Intraspinal Tumour Resection: Study Protocol for a Prospective Randomized Controlled Trial

Yue¹,

Zhou²,

Chong³

et al. 2022

JPR

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At present, it is believed that intravenous (IV) infusion of lidocaine can inhibit hyperalgesia, relieve postoperative acute and chronic pain, and accelerate the rehabilitation of patients. However, studies of its effects on necessary electrophysiological monitoring during neurosurgery are few, and the results are controversial. This study assumes that the propofol-remifentanil based anaesthesia combined with lidocaine in patients undergoing intraspinal tumour resection will not have adverse effects on motor-evoked potentials (MEPs) or somatosensory-evoked potentials (SEPs). Study Design and Methods: This is a prospective, randomized, placebo-controlled double-blind trial. A total of 96 patients undergoing intraspinal tumour resection will be randomly allocated to lidocaine and placebo group. The lidocaine group will receive IV lidocaine during anaesthesia, while the placebo group will receive the same dose of normal saline with the same infusion rate and infusion time, and the anaesthesia procedures of the two groups will be the same. All patients will be monitored the MEPs and SEPs of all four limbs during operation. The primary outcome will be the MEP amplitudes of both upper limbs at the end of operation. The secondary outcome measures will be the other electrophysiological parameters at the end of operation, the incidence of alert events for all four limbs, and the incidence of false positive events. Discussion: The purpose of this study is to evaluate the effects of IV infusion of lidocaine on SEPs and MEPs during intraspinal tumour resection to determine whether electrophysiological monitoring can accurately reflect the integrity of nerve functions while infusing lidocaine and to explore the possibility of lidocaine use during intraspinal tumour resection as an anaesthesia option.

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Systemic lidocaine and human somatosensoryevoked potentials during sufentanil-isoflurane anaesthesia

Abstract: 5, 20, and 40 minutes after lidocaine were 5.17 +.-1.33, 3.76 +--1.14, and3.66 +.-0.9 txg ' d1-1, respectively

Cited by 27 publications

References 31 publications

Current approach on spinal cord monitoring: the point of view of the neurologist, the anesthesiologist and the spine surgeon

Current approach on spinal cord monitoring: the point of view of the neurologist, the anesthesiologist and the spine surgeon

A retrospective study of anesthesia for subcutaneous ureteral bypass placement in cats: 27 cases

Effects of Lidocaine on Motor-Evoked Potentials and Somatosensory-Evoked Potentials in Patients Undergoing Intraspinal Tumour Resection: Study Protocol for a Prospective Randomized Controlled Trial

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