Systemic leukocyte activation in patients with central giant cell lesions

Souza, Paulo Eduardo Alencar; Gomez, Ricardo Santiago; Xavier, Guilherme M.; Santos, Janete Soares Coelho dos; Gollob, Kenneth J.; Dutra, Walderez Ornelas

doi:10.1111/j.1600-0714.2004.00276.x

Cited by 15 publications

(15 citation statements)

References 20 publications

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“…However, the possibilities that some subtypes of CGCG of the jaws (e.g. those associated with syndromes) may represent a neoplastic process 21,22 , akin to the giant cell tumor of bone, 23,24 or have a systemic component, 25 has not been conclusively ruled out.…”

Section: Case Presentationmentioning

confidence: 99%

Clinically aggressive central giant cell granulomas in two patients with neurofibromatosis 1

Edwards¹,

Rosenberg²,

Ruggiero³

et al. 2004

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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Section: Case Presentationmentioning

confidence: 99%

Clinically aggressive central giant cell granulomas in two patients with neurofibromatosis 1

Edwards¹,

Rosenberg²,

Ruggiero³

et al. 2004

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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“…The presence of osteoclast-like cells intermingled with mononuclear cells suggests that immune-inflammatory mechanisms may participate in the development of these lesions. Previous studies demonstrated alterations of the frequencies of circulating monocytes and lymphocytes that produce inflammatory and anti-inflammatory cytokines, including IL-10, in individuals with CGCL (9). IL-10 is one of the most important anti-inflammatory cytokines and it is also an inhibitory cytokine to macrophages function and bone resorption (10,11).…”

Section: Introductionmentioning

confidence: 99%

IL-10 and IL-10 receptor overexpression in oral giant cell lesions

Syrio¹,

Faria²,

Gomez³

et al. 2011

Med Oral

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Objective: Central giant cell lesions (CGCL) and peripheral giant cell lesions (PGCL) occur in the jaws and contain osteoclast-like giant cells and mononuclear cells positive for the macrophage marker CD68. The participation of immune-inflammatory mechanisms has been proposed in the lesions development. As IL-10 is one of the most important anti-inflammatory cytokines and it is also an inhibitory cytokine to macrophage function and bone resorption, the purpose of the present study was to investigate its expression together with its receptor (IL-10Rα) in CGCL and PGCL. Study Design: Six fragments of CGCL and seven fragments of PGCL were obtained by surgical excision. Frozen specimens were cut and subjected to immunofluorescence staining using fluorescent-labeled anti-CD68, anti-IL-10, and anti-IL-10Rα monoclonal antibodies. Microscopic analyses were performed and the percentage of positive mononuclear and giant cells for each parameter was obtained. Results: Our results revealed that all giant cells from CGCL and PGCL were CD68+ and IL-10Rα+ and that the majority was also positive for IL-10. More than 50% of the mononuclear cells from both lesions expressed IL-10Rα and the majority of these cells were CD68+ and IL-10+. Conclusion: Considering that IL-10 has inhibitory effects on the pathologic processes related to the development of the oral giant cell lesions, the high frequencies of cells producing this cytokine seems contradictory to these lesions growth. Investigation about the production of inflammatory cytokines as well as the IL-10 signaling pathways in oral giant cell lesions is required to elucidate the immunopathology of CGCL and PGCL.

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Section: Introductionmentioning

confidence: 99%

Clinically aggressive central giant cell granulomas in two patients with neurofibromatosis 1

Edwards

Fantasia

Saini

et al. 2006

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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Systemic leukocyte activation in patients with central giant cell lesions

Abstract: Our data indicate that, although CGCL is a localized lesion, the patients show systemic functional alterations in circulating leukocytes, suggesting their role in the inflammatory pathogenesis of CGCL.

Cited by 15 publications

References 20 publications

Clinically aggressive central giant cell granulomas in two patients with neurofibromatosis 1

Clinically aggressive central giant cell granulomas in two patients with neurofibromatosis 1

IL-10 and IL-10 receptor overexpression in oral giant cell lesions

Clinically aggressive central giant cell granulomas in two patients with neurofibromatosis 1

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