Systemic Inflammatory Response Syndrome in Surgical Patients

Abstract

Objective:To determine the incidence of systemic inflammatory response of the organism in surgical patients and its impact on the outcome of treatment.Methods:A prospective study was conducted on 60 patients undergoing abdominal surgical procedures, between January 2014 and December 2015 in the Surgery Clinic at the University Clinical Center Tuzla. Two groups of thirty were formed by the method of consecutive sampling. The first group consisted of subjects who were prepared for elective abdominal surgery (laparoscopic cholecystectomy), and the second group subjects underwent an emergency surgery due to acute abdomen (laparoscopic cholecystectomy).ResultsThe body temperature difference was statistically significant between the two investigated groups in all stages (c2: t0=3,486; t1=3,098; t2=2,453, t: t0=-11,210; t1=-7,360; t2=-4,927, p < 0,05). Non-elective surgery group had a statistical significant difference of the heart rate at all stages (c2: t0=3,873; t1=3,357; t2=3,227, t: t0=-16,524; t1=-10,407; t2=-9,842, p < 0,05). There is a statistically significant difference in the pCO2 values in all stages between groups (c2: t0=2,582; t1=1,678; t2=1,162, t: t0=4,323; t1=2,653; t2=2,229, p < 0,05). The SIRS score has a good positive correlation with the length of treatment, while the correlation with the outcome of treatment has no statistical significance.ConclusionInflammation scores monitoring in surgical patients is important for the surgical treatment success analysis. By modifying the therapy and influencing the inflammatory response, the results of treatment are improved.

Different Pharmacokinetics of Tramadol, O-Demethyltramadol and N-Demethyltramadol in Postoperative Surgical Patients From Those Observed in Medical Patients

“…To date, no study of tramadol metabolism has been conducted in surgical patients with signs of acute systemic inflammation, and this is the first study to include both elective and emergency patients with inflammatory conditions. Like previous studies, this one confirmed that urgent surgical patients with clinical signs of systemic inflammation were more likely to have low ChE activity (Becher et al, 2012;Smajic et al, 2018).…”

Effect of Laparatomy and Lipopolysaccharide-Induced Systemic Inflammatory Response on Metabolic Disorders in Rats

“…В основі патогенезу хірургічної травми, на думку дослідників, знаходиться системна запальна відповідь (СЗВ), яка у тяжких випадках призводить до розвитку синдрому, відомому як SIRS (від англ. Systemic inflammatory response syndrome) [3]. У деяких сприй нятливих осіб це може викликати розвиток синдрому поліорганної недостатності та смерть.…”

“…Навіть одинична лапаротомія здатна забезпечувати виникнення прозапального фенотипу, що включає нейроендокринний стрес, кіркову збудливість, імунну активацію, метаболічні зміни та коагулопатію [4]. Примітно, що такі складові патогенезу хірургічної травми, як психоемоційний стрес, ноцицептивні механізми, побічна дія анестетиків, крововтрата, разом з рановим процесом сприяють розвитку СЗВ [3]. Остання також є загальною реакцією організму при хронічному дифузному запаленні слабкої інтенсивності та може виявлятися за відсутності інших клінічних ознак [5].…”

Systemic inflammatory response in robot-assisted and laparoscopic surgery for colon cancer (SIRIRALS): study protocol of a randomized controlled trial

“…This response is due to a cascade of neuroendocrine, metabolic and immunological factors. In the systemic acute inflammatory reaction, a release of pro-inflammatory cytokines (IL-1β, IL-6 and TNF) occurs as part of wound healing by producing acute phase reactants (C-reactive protein (CRP), fibrinogen and complement C3) as a reaction to the initial surgical trauma [ 11 , 12 ]. High concentrations of pro-inflammatory cytokines (predominantly IL-6) and lack of compensatory expression of anti-inflammatory cytokines may cause systemic inflammatory response syndrome (SIRS).…”