Systemic inflammatory response in predicting outcomes of patients undergoing curative resection for oral squamous cell carcinoma

Zubair, Farhan; McMahon, Jeremy; Kryklyas, Ganna; Wicks, Catherine

doi:10.1016/j.bjoms.2021.10.017

Cited by 7 publications

(3 citation statements)

References 16 publications

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“…Nine studies (1154 cases) included people of Asian ethnicity, and two studies (863 cases) were included people of non-Asian ethnicities. Regarding tumor location, two studies included 221 patients with hypopharyngeal cancer, 14,22 two enrolled 859 patients with oral cavity cancer, 13,23 and seven enrolled 937 patients with mixed tumor locations (more than 1 tumor location was considered in the study). 12,[24][25][26][27][28][29] Of the 11 studies, 5 involved patients with a mixed TNM stage (I-IV), 3 involved patients who underwent nivolumab as palliative treatment for recurrent/metastatic HNSCC, and 2 included only patients with an advanced TNM stage (III-IV).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Two studies involving 863 patients with HNSCC reported the prognostic influence of mGPS on DSS, 23,24 and the heterogeneity was high (I 2 = 70.2%, P H = 0.035). In accordance with the results of a pooled analysis, high mGPS had a significant association with poor DSS in patients with HNSCC (HR = 2.57, 95% CI 1.71-3.88, p < 0.001; Figure 4).…”

Section: Effect Of the Mgps On Dss And Pfsmentioning

confidence: 99%

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Utility of modified Glasgow prognostic score for head and neck squamous cell carcinoma: Systematic review and meta‐analysis

et al. 2023

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Whether the modified Glasgow prognostic score (mGPS) is useful for patients with head and neck squamous cell carcinoma (HNSCC) remains controversial.An electronic database search on EMBASE, PubMed, and the Cochrane Library from inception to 30 June 2022 was performed for study selection and data extraction. The associations between the mGPS and survival outcomes were evaluated using a random-effects meta-analysis and expressed as pooled hazard ratios (HRs) and 95% CIs. We included 11 studies involving a total of 2017 patients with HNSCC. A higher mGPS was associated with poorer progression-free survival (HR = 2.39, 95% CI 1.69-3.38), overall survival (HR = 2.40, 95% CI 1.94-2.98), disease-specific survival (HR = 2.57, 95% CI 1.71-3.88), and disease-free survival (HR = 2.67, 95% CI 1.51-4.73, all p ≤ 0.001) in HNSCC. The mGPS can function as a valid prognostic biomarker for patients diagnosed as having HNSCC.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Effect Of the Mgps On Dss And Pfsmentioning

confidence: 99%

Utility of modified Glasgow prognostic score for head and neck squamous cell carcinoma: Systematic review and meta‐analysis

et al. 2023

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“…Studies have shown that PLR, as an indicator of the combination of platelet count and lymphocyte count in the body, can re ect not only the tumor-promoting state and in ammatory response in the body, but also the anti-tumor immune state. SUN et al[32] found that PLR is a prognostic factor affecting PFS and OS in non-metastatic NPC, while some studies[33][34][35][36] believed that PLR is not signi cantly correlated with survival and prognosis of NPC, which may be attributed to tumor heterogeneity. In this study, pre-PLR was related to the gender, T stage, clinical stage, ECOG, pathological type, pre-HGB and pre-ALB of patients with NPC, which was consistent with the conclusion of JIANG et al[31] who studied 247 patients with NPC who received IMRT.…”

mentioning

confidence: 99%

Combined pretreatment neutrophil-lymphocyte ratio and platelet-lymphocyte ratio predicts survival and prognosis in patients with non-metastatic nasopharyngeal carcinoma: a retrospective study

Yang,

Li,

et al. 2023

Preprint

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Background Local recurrence and distant metastasis is the main cause of treatment failure in nasopharyngeal carcinoma (NPC). It is necessary to find a reliable, economical and convenient prognostic indicator to accurately predict the prognosis of NPC. The clinical significance of the combination of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) is unclear. This study investigated the predictive value of pretreatment NLR (pre-NLR) combined with pretreatment PLR (pre-PLR) for the survival and prognosis of NPC. Methods We retrospectively analyzed 765 patients with non-metastatic NPC. The NLR and PLR before treatment were examined. The pre-NLR-PLR scoring criteria and grouping were as follows: HRG, score of 2, high pre-NLR and high pre-PLR. MRG, score of 1, either high pre-NLR or high pre-PLR. LRG, score of 0, neither high pre-NLR nor high pre-PLR. We compared survival rates and factors affecting the prognosis among different groups. Receiver operating characteristic (ROC) curves were used to identify the cutoff-value and discriminant performance of the model. Results The ROC curve indicated a cut-off value of 3.29 for pre-NLR and 196.74 for pre-PLR. The 5-year overall survival (OS), locoregional recurrence-free survival (LRRFS) and distant metastasis-free survival (DMFS) of NPC patients in HRG were significantly poorer than those in MRG and LRG. The pre-NLR-PLR score was positively correlated with T stage, clinical stage, ECOG score and pathological classification. Multivariate cox regression analysis showed that pre-NLR-PLR scoring system, ECOG score and pre-ALB were independent risk factors affecting 5-year OS, 5-year LRRFS and 5-year DMFS in NPC patients. Age, T stage, smoking history were independent risk factors for 5-year OS. Age, pathological type, smoking history were independent risk factors for 5-year LRRFS. T stage and N stage were independent risk factors for 5-year DMFS. The ROC curve showed that area under the curve (AUC) values of pre-NLR-PLR of 5-year OS, LRRFS and DMFS in NPC were higher than those of pre-NLR and pre-PLR. Conclusions pre-NLR-PLR is an independent risk factor for the prognosis of NPC. The pre-NLR-PLR scoring system can be used as an individualized clinical assessment tool to predict the prognosis of patients with non-metastatic NPC more accurately and easily.

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Patterns of recurrence amongst patients undergoing resection of oral squamous cell carcinoma with curative intent

Zubair

Farooq²,

Wright³

et al. 2022

British Journal of Oral and Maxillofacial Surgery

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Systemic inflammatory response in predicting outcomes of patients undergoing curative resection for oral squamous cell carcinoma

Cited by 7 publications

References 16 publications

Utility of modified Glasgow prognostic score for head and neck squamous cell carcinoma: Systematic review and meta‐analysis

Utility of modified Glasgow prognostic score for head and neck squamous cell carcinoma: Systematic review and meta‐analysis

Combined pretreatment neutrophil-lymphocyte ratio and platelet-lymphocyte ratio predicts survival and prognosis in patients with non-metastatic nasopharyngeal carcinoma: a retrospective study

Patterns of recurrence amongst patients undergoing resection of oral squamous cell carcinoma with curative intent

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