Systemic inflammatory response after hernia repair: a systematic review

Kokotovic, Dunja; Burcharth, Jakob; Helgstrand, Frederik; Gögenur, Ismail

doi:10.1007/s00423-017-1618-1

Cited by 32 publications

(11 citation statements)

References 57 publications

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“…However, we did not observe any specific compensatory anti‐inflammatory response (ie no change in IL‐10, IL‐11) as a consequence of the more pronounced pro‐inflammatory response observed. Temporal development of pro‐ and anti‐inflammatory markers may explain this observation, since measurements were at 4 and 24 hours after end of surgery, and a compensatory response seems to occur 2‐3 days after the initial response 18,19 …”

Section: Discussionmentioning

confidence: 98%

Effect of tranexamic acid on markers of inflammation in children undergoing craniofacial surgery

Fenger-Eriksen

Rasmussen

Juul

et al. 2020

Acta Anaesthesiol Scand

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Background Tranexamic acid (TXA) reduces blood loss and transfusion requirements during craniosynostosis surgery in small children. Possible interaction from TXA on the inflammatory system is unknown. Objective To evaluate the effect of TXA on a wide range of inflammatory markers in children receiving TXA in a randomized, blinded, and placebo controlled study design. Methods Thirty children undergoing craniosynostosis surgery with significant blood loss received TXA (bolus dose of 10 mg kg−1 followed by 8 hours continuous infusion of 3 mg kg−1 h−1) or placebo in a randomized, double‐blinded study design. Using a new proximity extension assays employing a panel of inflammatory biomarkers samples was used for analysis of blood samples obtained pre‐operatively, 4 and 24 hours after operation. Results Ninety‐two inflammatory parameters were measured. TXA did not affect any of the measured parameters as compared with placebo. Among 34 of the 92 pro‐ and antiinflammatory parameters investigated changes were observed between pre‐operative, 4 or 24 hours, respectively, reflecting immune activation during surgical stress. Conclusion TXA administration in a low‐dose regimen including bolus followed by 8 hours infusion during craniosynostosis surgery did not change any of 92 inflammatory markers as compared with placebo.

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Section: Discussionmentioning

confidence: 98%

Effect of tranexamic acid on markers of inflammation in children undergoing craniofacial surgery

Fenger-Eriksen

Rasmussen

Juul

et al. 2020

Acta Anaesthesiol Scand

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“…Surgical procedures such as hernia repair elicit a systemic inflammatory response, which is characterized by increase in C‐reactive protein, leukocytes, neutrophils, interleukin‐1 (IL‐1), IL‐6, fibrinogen, and α1‐antitrypsin, and decreases in lymphocytes and albumin 15 . The current study shows that, in comparison with the other two groups, dexmedetomidine premedication significantly reduced postoperative TNF‐α and IL‐6 levels in children undergoing elective hernia repair surgery.…”

Section: Discussionmentioning

confidence: 99%

The effect of dexmedetomidine premedication on postoperative systemic inflammatory response in children undergoing hernia repair surgery: A randomized controlled trial

Wei

Zhang

et al. 2021

Pediatric Anesthesia

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Background Surgery results in systemic inflammation, which can affect the central nervous system, leading to changes in mood, emotion, and behavior. Our previous study has shown that compared to midazolam, dexmedetomidine premedication effectively decreased children's postoperative anxiety. Aim To investigate whether dexmedetomidine infusion before hernia repair alleviates postoperative systemic inflammation in children and whether postoperative anxiety may be associated with postoperative inflammation. Methods This prospective double‐blind randomized controlled trial was conducted in 120 children scheduled to undergo elective hernia repair. Before anesthesia induction, all children received an intravenous infusion consisted of dexmedetomidine (n = 40; 0.5 µg/g, group D), midazolam (n = 40; 0.08 mg/kg, group M), or normal saline (n = 40; group C). One‐way ANOVA with least significant difference multiple comparison test was used for multigroup comparisons of postoperative plasma levels of inflammatory cytokines and m‐YPAS scores. Spearman rank correlation tests were used for analyzing m‐YPAS scores with postoperative plasma levels of inflammatory cytokines. Results Plasma levels of tumor necrosis factor‐alpha (7.0 ± 1.6 vs. 8.1 ± 1.6, mean difference [95% CI]: 1.19 [0.26–2.11], p = .008) (pg/ml) and of interleukin‐6 (1.8 ± 1.2 vs. 3.3 ± 1.6, mean difference [95% CI]: 1.49 [0.74–2.25], p < .001) (pg/ml) and neutrophils‐to‐lymphocyte ratio (1.0 ± 0.5 vs. 1.5 ± 0.7, mean difference [95% CI]: 0.48 [0.17–0.78], p < .001) were significantly lower in group D than in group C. Furthermore, compared to group M, group D showed significantly lower plasma tumor necrosis factor‐alpha levels (7.0 ± 1.6 vs. 7.9 ± 1.9, mean difference [95% CI]: 0.96 [0.04–1.88], p = .04) (pg/ml) and interleukin‐6 levels (1.8 ± 1.2 vs. 2.9 ± 1.5, mean difference [95% CI]: 1.06 [0.31–1.81], p = .004) (pg/ml), and neutrophil‐to‐lymphocyte ratio (1.0 ± 0.5 vs. 1.5 ± 0.6, mean difference [95% CI]: 0.42 [0.11–0.72], p = .004). Anxiety scores at postoperative 2 and 4 h in the three groups positively correlated with plasma levels of proinflammatory cytokines. Conclusion A single preoperative intravenous dexmedetomidine dose in children undergoing same‐day surgery reduces postoperative systemic inflammation.

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“…Algunos artículos demuestran que la hernioplatia para tratar las hernias recidivadas con la TEP produce menor respuesta inflamatoria que las abiertas 86 . Los pacientes tratados con hernioplastias protésicas tienen mayor concentración sérica de PCR e IL-6 que los con solo herniorrafias, siendo mayor el nivel de marcadores en la cirugía abierta que en la videoasistida 87 . La técnica de Stoppa genera mayor respuesta inflamatoria que la TEP, y esta, con menor dolor posoperatorio y tiempo de hospitalización 88 .…”

Section: ¿Por Qué Es Desconocida O Silenciada La Dimensión De La Agreunclassified

Dermatome mapping test (DMT) and it’s place on triple and selective neurectomy in patients with post-operative chronic inguinal pain

Quintero¹

2019

Rev Hispanoam Hernia

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El dolor inguinal posoperatorio crónico (somático o neuropático) es la secuela más frecuente, importante y limitante de la cirugía herniaria inguinal, cuya prevalencia exacta se desconoce. El trabajo expone, bajo una visión personal, sinóptica y objetiva, algunas connotaciones sobre la génesis de los tipos de dolor inguinal, especialmente el neuropático, generado por la agresión técnica (invasividad, disectividad y reparatividad), sobre áreas anatómicas específicas por las que discurren los correspondientes nervios inguinales periféricos, expuestos a riesgos neurolesivos por posibles maniobras inapropiadas. Para mejorar la comprensión de la agresividad tisular y de la posible potencialidad neurolesiva de las técnicas hernioplásticas, se aportan 2 clasificaciones (personales, inéditas, intuitivas y objetivas). La primera, relaciona a grupos y modelos hernioplásticos con la dimensión cuantitativa (cm) y la extensión cualitativa de la invasividad (maxi, normo, mini o mínimamente invasivas), así como la extensión cualitativa (maxi, normo y minidisectivas) y la dimensión cuantitativa de la disectividad (superficie y volumen disectivo de técnicas abiertas y videoasistidas). La segunda clasificación relaciona a los mismos grupos y modelos técnicos con sus respectivas potencialidades neurolesivas sobre las respectivas áreas críticas de riesgo de dolor crónico neuropático, según el probable o improbable riesgo de lesionar determinados nervios en dichas áreas anatómicas, identificando además el posible efecto profiláctico que pudieran ejercer algunas de las opciones técnicas en la prevención del dolor crónico neuropático. Sin duda, es la experiencia, la pericia y la maestría técnico-científica del cirujano, la mejor profilaxis de la inguinodinia.

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Systemic inflammatory response after hernia repair: a systematic review

Cited by 32 publications

References 57 publications

Effect of tranexamic acid on markers of inflammation in children undergoing craniofacial surgery

Effect of tranexamic acid on markers of inflammation in children undergoing craniofacial surgery

The effect of dexmedetomidine premedication on postoperative systemic inflammatory response in children undergoing hernia repair surgery: A randomized controlled trial

Dermatome mapping test (DMT) and it’s place on triple and selective neurectomy in patients with post-operative chronic inguinal pain

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