Systemic Inflammatory Markers, Periodontal Diseases, and Periodontal Infections in an Elderly Population

Bretz, Walter A.; Weyant, Robert J.; Corby, Patricia; Ren, Dianxu; Weissfeld, Lisa A.; Kritchevsky, Stephen B.; Harris, Tamara B.; Kurella, Manjula; Satterfield, Suzanne; Visser, Marjolein; Newman, Anne B.

doi:10.1111/j.1532-5415.2005.53468.x

Cited by 161 publications

(132 citation statements)

References 26 publications

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“…A thorough and deep research of the differences including the difference of genes related to inflammation between H-PDLSC and P-PDLSC is going to be one of interesting research direction. Furthermore, several studies indicated that the expression of IL-1b and TNF-a is higher in diseased periodontal tissue than in healthy periodontal tissue [24][25][26][27][28]. We also found that the expression levels of both inflammatory cytokines were significantly higher in P-PDLSCs by 6.1-and 2.3-fold, respectively, relative to H-PDLSCs (data not shown).…”

Section: Discussionsupporting

confidence: 61%

“…As a key negative regulator in osteoblast differentiation, elevated TNF-a has been shown to induce bone loss through upregulation of Smurf1 levels [58]. In microenvironments of choric periodontitis, compared to healthy sites, local TNF-a levels have been found to be significantly elevated and are associated with periodontal tissue destruction [24][25][26][27][28]40]. Consistently, excessive inflammatory cytokines levels, which are induced directly, target Smurf1 expression, indicating that osteoblast inhibitory signals are dominant over the inhibition of osteogenic differentiation potential in PDLSCs.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies showed that the expression levels of two major inflammatory cytokines of periodontitis, Interleukin (IL)-1b and TNF-a, were significantly higher in periodontal diseases [24][25][26][27][28]. To confirm whether inflammatory cytokines affect miR-17 and Smurf1 expression during osteoblast differentiation, H-PDLSCs were cultured in osteoblast differentiation medium in the presence or absence of IL-1b (1 ng/ ml) or TNF-a (10 ng/ml) for 7 days.…”

Section: The Effects Of Mir-17 On H-pdlscs Osteoblast Differentiationmentioning

confidence: 99%

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MiR-17 Modulates Osteogenic Differentiation Through a Coherent Feed-Forward Loop in Mesenchymal Stem Cells Isolated from Periodontal Ligaments of Patients with Periodontitis

et al. 2011

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Chronic inflammatory diseases, such as rheumatoid arthritis and periodontitis, are the most common causes of bone tissue destruction. Recently, human periodontal ligament tissue-derived mesenchymal stem cells (PDLSCs), a population of multipotent stem cells, have been used to reconstruct tissues destroyed by chronic inflammation. However, the impact of the local inflammatory microenvironment on tissue-specific stem cells and the mechanisms controlling the effects of the local inflammatory environment remain poorly understood. In this study, we found that the multidifferentiation potential of mesenchymal stem cells (MSCs) isolated from periodontitis-affected periodontal ligament tissue (P-PDLSCs) was significantly lower than that of MSCs isolated from healthy human periodontal ligament tissue (H-PDLSCs). Inflammation in the microenvironment resulted in an inhibition of miR-17 levels, and a perturbation in the expression of miR-17 partly reversed the differentiation potential of PDLSCs in this microenvironment. Furthermore, inflammation in the microenvironment promoted the expression of Smad ubiquitin regulatory factor one (Smurf1), an important negative regulator of MSC osteogenic differentiation. Western blotting and 3′ untranslated regions (3′-UTR) reporter assays confirmed that Smurf1 is a direct target of miR-17 in PDLSCs. Our data demonstrate that excessive inflammatory cytokine levels, miR-17, and Smurf1 were all involved in a coherent feed-forward loop. In this circuit, inflammatory cytokines led to direct activation of Smurf1 and downregulation of miR-17, thereby increasing degradation of Smurf1-mediated osteoblast-specific factors. The elucidation of the molecular mechanisms governing MSC osteogenic differentiation in a chronic inflammatory microenvironment could provide us with a better knowledge of chronic inflammatory disorder and improve stem cell-mediated inflammatory bone disease therapy.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: The Effects Of Mir-17 On H-pdlscs Osteoblast Differentiationmentioning

confidence: 99%

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MiR-17 Modulates Osteogenic Differentiation Through a Coherent Feed-Forward Loop in Mesenchymal Stem Cells Isolated from Periodontal Ligaments of Patients with Periodontitis

et al. 2011

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“…Second, we relied on historical measures of periodontal disease, and not "active" measures. Future endeavors will be directed at measuring serum antibodies to periodontal organisms, as well as inflammatory cytokines (41).…”

Section: Discussionmentioning

confidence: 99%

Severe Periodontitis Is Associated with Low Serum Albumin among Patients on Maintenance Hemodialysis Therapy

Kshirsagar

Craig

Beck

et al. 2007

Clinical Journal of the American Society of Nephrology

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The relationship between periodontitis and two measures of systemic inflammation, serum albumin and C-reactive protein (CRP), were examined among patients who were receiving chronic outpatient hemodialysis. Adult patients at two locations, North Carolina and New York City, were evaluated by dentist examiners. Six sites per tooth (up to 32 teeth per patient) were examined. A periodontitis case was defined as >60% of sites with attachment level >4 mm. Multivariable logistic regression was used to determine the association of periodontitis with low serum albumin, defined as <3.5 mg/dl, and with high CRP, defined as >3.0 mg/dl. A total of 154 patients completed the study. The mean age was 54.6 yr (SD 13.3), and average duration of dialysis was 4.0 yr (3 mo to 16 yr). Eighty-six (54.6%) were men, and 89 (58.2%) were black. Common causes of end-stage kidney disease were hypertension (12.3%), diabetes (22.1%), glomerulonephritis (7.1%), and other (58.4%). The average number of teeth was 20.3 (SD 8.4). Thirty-five (23%) patients were periodontitis cases. Severe periodontitis was associated with low serum albumin (odds ratio 8.20; 95% confidence interval 1.61 to 41.82; P ‫؍‬ 0.01) compared with individuals without severe periodontitis disease after adjustment for age, gender, race, diabetes, hypertension, body mass index, smoking, study site, total cholesterol, serum calcium, serum phosphorus, and normalized protein catabolic rate. There was no observed association of severe periodontitis with CRP. Investigation of the potential contribution of periodontitis to serum albumin and possibly to morbidity and mortality among patients with end-stage kidney disease seems warranted.

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“…Noble et al 46 found that patients who have high levels of serum antibodies to periodontal bacteria have lower scored on delayed word recall and calculation tasks. Bretz et al 47 investigated the IL-6 serum level at periodontal disease patients. The results were significantly higher than the control group.…”

Section: öZetmentioning

confidence: 99%

The Relationship Between Periodontal Disease and Alzheimer’s Disease

Orbak¹,

Öztürk²

2016

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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Alzheimer's disease(AD) is a neurodegenerative disease that effects elder people. As the age increases, the prevalance of Alzheimer's disease also raises. As AD, periodontitis is seen more often in elder people. Periodontal disease has been associated with some systemical diseases such as cardiovascular diasease(CVS), diabetes mellitus, rheumatoid arthritis and preterm birth. Latterly, it has been investigated if there is a connection between Alzheimer's diasease. This review's aim is, inspecting if the periodontal disease contributes to Alzheimer's disease at literacy.

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Systemic Inflammatory Markers, Periodontal Diseases, and Periodontal Infections in an Elderly Population

Abstract: Periodontal disease and infection may be modifiable risk indicators for elevated levels of systemic inflammatory markers in older people.

Cited by 161 publications

References 26 publications

MiR-17 Modulates Osteogenic Differentiation Through a Coherent Feed-Forward Loop in Mesenchymal Stem Cells Isolated from Periodontal Ligaments of Patients with Periodontitis

MiR-17 Modulates Osteogenic Differentiation Through a Coherent Feed-Forward Loop in Mesenchymal Stem Cells Isolated from Periodontal Ligaments of Patients with Periodontitis

Severe Periodontitis Is Associated with Low Serum Albumin among Patients on Maintenance Hemodialysis Therapy

The Relationship Between Periodontal Disease and Alzheimer’s Disease

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