Systemic inflammation, oxidative stress and apolipoprotein B/A1 ratio in active psoriasis: bridging an apparent paradox

Saxena, Rahul; Suneja, Shilpa; Saxena, Rahul; Sharma, Deepak; Lal, Alok Milton

doi:10.18203/issn.2455-4529.intjresdermatol20160350

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…The above biomarkers were selected to determine t h e l e v e l s o f i n f l a m m a t i o n b a s e d o n t h e reported association between psoriasis and these biomarkers [41]. Previous studies showed an increase in serum levels of IL-6, IL-8, IL-10, IL-23, lipoprotein (a), chemerin, TNF-α, hs-CRP, osteopontin, D-dimer, Troponin I, creatinine, bilirubin, creatinine, and the platelet count in patients with psoriasis, and a decrease in the serum levels of adiponectin, paraoxonase, and cortisol [21,32,. Serum osteopontin was selected as a biomarker for the calculation of the SOFA scale depending on its role as the bridging of adaptive and innate immunity in autoimmune diseases, including psoriasis [65].…”

Section: Discussionmentioning

confidence: 97%

“…In the literature, numerous studies have reported systemic changes, such as dyslipidemia, cytokines, and inflammatory and immunologic biomarker abnormalities [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. Some researchers suggest that psoriasis is a systemic disease rather than a local skin disease [6,7,17,[28][29][30][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

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Psoriasis is a systemic disease: A proposed approach for inflammation scale calculation

Alsamarai¹,

Alobaidii²

2021

Our Dermatol Online

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Background: Psoriasis is a skin disease affecting 2.3% of the Iraqi population and begins as a local disease with subsequent systemic comorbidities. Aim: The aim was to clarify whether psoriasis is a local or systemic disease. Materials and Methods: A total of 211 subjects with psoriasis and 163 sex- and age-matched controls were included in the study. Serum adiponectin, interleukin-6, interleukin-8, interleukin-10 (IL-10), interleukin-23 (IL-23), interleukin-18 (IL-18), paraoxonase, lipoprotein (a), osteopontin, chemerin, tumor necrosis factor-a (TNF-a), high-sensitivity C- reactive protein (hs-CRP), bilirubin, D-dimer, and creatinine were determined using commercial kits. Results: There was no significant difference in the mean age and BMI between psoriasis and the control groups. However, there was significantly higher mean serum values of IL-6, IL-8, IL-10, IL-23, lipoprotein (a), chemerin, TNF-a, hs-CRP, osteopontin, D-dimer, troponin I, creatinine, bilirubin, and platelet counts in psoriatic patients than in the controls. Meanwhile, the serum mean values of adiponectin, paraoxonase, and cortisol were significantly lower in psoriasis subjects than in the controls. The mathematical model was proposed to clarify whether psoriasis is a systemic or local disease. The application of the model to our data of biomarkers indicated the presence of systemic inflammation in psoriasis. Conclusion: The present study finding suggests that psoriasis is a systemic disease rather than a local skin disease. However, there is a need for the application of the model in a large-scale study.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Psoriasis is a systemic disease: A proposed approach for inflammation scale calculation

Alsamarai¹,

Alobaidii²

2021

Our Dermatol Online

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“…Previous studies indicated that psoriasis started as local skin disease and subsequently associated with systemic inflammatoryimmunologic and metabolic changes [7,8] . The systemic changes in patients with psoriasis were reported in studies conducted in Iraqi population [5,6,9,10] and worldwide [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. The data presented in the above studies that are from different global communities indicated that psoriasis co-morbidities development are not confined to specific race, developing or developed communities.…”

Section: Introductionmentioning

confidence: 84%

Psoriasis Beyond Local Skin Disease

2021

MLU

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Background: Psoriasis is a skin disease that was associated with metabolic and clinical changes which suggest that psoriasis is a systemic rather than local disease.Aim: To illustrate whether psoriasis is local or systemic disease through analysis of some biomarkers. Materials andMethod: A 256 subjects with psoriasis and 221 sex and age matched controls were included in the study. Serum total cholesterol [TC], high density lipoprotein [HDL], Malondialdehyde [MDA], triglycerides [TG], and total antioxidant capacity [TCA] were determined using commercial kits.Results: There were no significant differences between psoriasis and control groups in regards to mean age and gender distribution, however, there was a significant difference [p<0.01] in BMI. Additionally, TC, TG, LDL and NHDL were significantly higher [P<0.001] in patients with psoriasis than in controls, while HDL was significantly lower in psoriasis than in controls. MDA mean serum level was significantly higher [P<0.001] lower while TCA value was significantly [P<0.001] lower in subjects with psoriasis as compared controls. Lipid profile rates and oxidation index were significantly higher in psoriasis than in controls, while the anti-oxidation index was significantly lower in psoriasis. Conclusion:These study findings suggest that psoriasis may be a systemic disease rather than local skin disease.

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“… 42 , 44 , 45 APOB is implicated in lipid metabolism, and is upregulated with oxidative stress and systemic inflammation. 46 It has been shown that APOB predicts coronary heart disease-specific mortality. 47 Thus, one working hypothesis suggested by these findings is that oxidative stress and inflammation may contribute to induce cellular senescence and subsequent production of SASP proteins that circulate in blood and both locally and systemically have negative effects on the hematopoietic system leading to impaired erythropoiesis and high RDW.…”

Section: Discussionmentioning

confidence: 99%

Proteins in the pathway from high red blood cell width distribution to all-cause mortality

Osawa¹,

Tanaka²,

Semba³

et al. 2022

eBioMedicine

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Summary Background The pathophysiological mechanisms underlying the association between red blood cell distribution width (RDW) and all-cause mortality are unknown. We conducted a data-driven discovery investigation to identify plasma proteins that mediate the association between RDW and time to death in community-dwelling adults. Methods At baseline, 962 adults (women, 54·4%; age range, 21–98 years) participated in the InCHIANTI, “Aging in the Chianti Area” study, and proteomics data were generated from their plasma specimens. Of these, 623 participants had proteomics data available at the 9-year follow-up. For each visit, a total of 1301 plasma proteins were measured using SOMAscan technology. Complete data on vital status were available up to the 15-year follow-up period. Protein-specific exponential distribution accelerated failure time, and linear regression analyses adjusted for possible covariates were used for mortality and mediation analyses, respectively (survival data analysis). Findings Baseline values of EGFR, GHR, NTRK3, SOD2, KLRF1, THBS2, TIMP1, IGFBP2, C9, APOB, and LRP1B mediated the association between baseline RDW and all-cause mortality. Changes in IGFBP2 and C7 over 9 years mediated the association between changes in RDW and 6-year all-cause mortality. Interpretation Cellular senescence may contribute to the association between RDW and mortality. Funding This study was funded by grants from the National Institutes of Health (NIH) and the National Institute on Aging (NIA) contract and was supported by the Intramural Research Program of the NIA, NIH. The InCHIANTI study was supported as a ‘targeted project’ by the Italian Ministry of Health and in part by the U.S. NIA.

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Systemic inflammation, oxidative stress and apolipoprotein B/A1 ratio in active psoriasis: bridging an apparent paradox

Cited by 4 publications

References 9 publications

Psoriasis is a systemic disease: A proposed approach for inflammation scale calculation

Psoriasis is a systemic disease: A proposed approach for inflammation scale calculation

Psoriasis Beyond Local Skin Disease

Proteins in the pathway from high red blood cell width distribution to all-cause mortality

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