Systemic Inflammation in Patients with Chronic Obstructive Pulmonary Disease Who Are Colonized with Pneumocystis jiroveci

Abstract

In chronic obstructive pulmonary disease, high levels of airway and systemic inflammatory markers are associated with a faster decrease in lung function. Our study shows that patients colonized by Pneumocystis jiroveci have higher proinflammatory cytokine levels than do noncolonized patients. This suggests that Pneumocystis may play a role in disease progression.

Investigation of Pneumocystis jirovecii Pneumonia and Colonization in Iatrogenically Immunosuppressed and Immunocompetent Patients

“…Hematolojik malignitelerdeki P.jirovecii pozitifl iklerinin %80'i kolonizasyon olarak değerlendirilirken, bu oran solid tümörlerde %60, organ transplantasyonlarında %43 ve İ/OİH'da %20 olarak bulunmuştur (Tablo I). Yapılan çalışmalarda, KOAH, İAH, kistik fi brozis ve Akc-Ca gibi kronik akciğer hastalıklarında %2.6-55 arasında P.jirovecii kolonizasyonu saptandığı gösterilmiştir [26][27][28][29][30] . Ayrıca bu hastalıkların gelişiminde ve progresyonunda kolonizasyonun etkili olabileceği vurgulanmıştır 26,27 .…”

The relationship between Candida species cultured from the respiratory tract and systemic inflammation in critically ill patients with ventilator-associated pneumonia

“…19 In addition, procalcitonin (PCT), tumour necrosis factor alpha (TNF-a), and interleukin (IL)-6 are elevated in infection and have been associated with worse outcomes in critically ill patients. Hence, evaluating the relationship between markers of systemic inflammation and the presence of Candida in RT secretions may provide insight as to the impact of Candida on patient outcomes.…”

La transmission des infections àPneumocystis

“…Les femmes enceintes, les patients sous corticoïdes, immunodéprimés, atteints de maladies systémiques ou encore de maladies pulmonaires chroniques comme la bronchopneumopathie chronique obstructive (BPCO) peuvent également être colonisés par le champignon [6]. Il est intéressant de noter que des arguments cliniques et expérimentaux de plus en plus nombreux indiquent que Pneumocystis peut être un facteur de comorbidité chez les patients atteints de BPCO [8,9]. Ainsi, lorsque l'on parle d'infection par Pneumocystis, on ne peut plus se limiter à la PcP et à son caractère opportuniste.…”