Systemic inflammation in COPD is not influenced by pulmonary rehabilitation

Abstract

Background: Pulmonary Rehabilitation (PR) is known to lead to improvements in exercise tolerance, health related quality of life and help reduce symptoms. Exercise, although of great benefit, can increase the inflammatory response related to Chronic Obstructive Pulmonary Disease, depending on intensity and duration. Through this study, the effects of a 12 week, high intensity PR programme on COPD inflammatory related markers were investigated. and exhaled NO at baseline and upon completion of the programme.Results: This 12 week PR programme resulted in significant improvements in both the 6MW distance and health quality of life, but resulted in no changes in the inflammatory markers. Conclusion:Beneficial effects on functional and HR-QoL measures resulted, which however appear unrelated to changes in the systemic inflammatory markers.

Exercise modulates the immune system in cardiorespiratory disease patients: Implications for clinical practice during the COVID-19 pandemic

“…In addition, some studies have reported that the degree of inflammation in cardiorespiratory-related problems is related to workout intensity. However, there remains uncertainty in these results 15 , 16 , 17 , 18 . In contrast, other studies have found that physical activity's amelioratory effects on cardiorespiratory problems 19 and interval training's positive effects are better than other types of training.…”

Exercise Training in Patients with Chronic Respiratory Diseases: Are Cardiovascular Comorbidities and Outcomes Taken into Account?—A Systematic Review

“…In general, 22.8% of the studies [23,48,50,55,63,67,69,73,77,78,79,80,83,84,86,88,91,95,97,110,111,115,122,126,127,132,142,149,150,155,161,165,175,185,187,189,190,193,197,205,206] did not report information about the eligibility criteria, 18.3% of the studies [33,42,54,65,66,72,82,96,98,99,101,108,116,117,118,119,128,137,141,143,145,146,180,182,194,195,200,201,202,203,207,208,…”

Changes in systemic inflammation after pulmonary rehabilitation in patients with COPD and severe physical inactivity – an exploratory study

“…COPD-related sarcopenia and especially sarcopenic obesity is associated with short walking distance and increased systemic inflammation. [37][38][39][40] We did not include data on body composition, hand-grip strength, leg circumference, timed up-and-go test, or other measures related to muscle strength but sarcopenia is a known riskfactor for physical inactivity in COPD. 38,41 Studies investigating changes in systemic inflammation during PR in patients with COPD-related sarcopenia are therefore needed.…”

“…The literature on changes in systemic inflammation during PR is contradictory: some studies report no changes, 39,[42][43][44] whereas others show reduction in eg. IL-8, 45 IL-6, 46 and CRP 46 supporting that exercise is an efficient and inflammation lowering activity.…”