Systemic Inflammation and Endothelial Dysfunction—a Possible Link Between Osteoarthritis and Hypertension: Comment on the Article by Niu et al

Sabio, José Mario

doi:10.1002/art.40213

Arthritis & Rheumatology

2017

DOI: 10.1002/art.40213

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Systemic Inflammation and Endothelial Dysfunction—a Possible Link Between Osteoarthritis and Hypertension: Comment on the Article by Niu et al

José Mario Sabio

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2024

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Osteoarthritis and hypertension: observational and Mendelian randomization analyses

Yang,

Liu,

Liu

et al. 2024

Arthritis Res Ther

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Background The association between osteoarthritis (OA) and hypertension is a subject of ongoing debate in observational research, and the underlying causal relationship between them remains elusive. Methods This study retrospectively included 24,871 participants in the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2020. Weighted logistic regression was performed to investigate the connection between OA and hypertension. Additionally, Mendelian randomization (MR) analysis was conducted to explore the potential causal relationship between OA and hypertension. Results In the NHANES data, after adjusting for multiple confounding factors, there was no significant relationship between OA and hypertension (OR 1.30, 95% CI, 0.97–1.73, P = 0.089). However, among males, OA appeared to be associated with a higher risk of hypertension (OR 2.25, 95% CI, 1.17–4.32, P = 0.019). Furthermore, MR results indicate no relationship between multiple OA phenotypes and hypertension: knee OA (IVW, OR 1.024, 95% CI: 0.931–1.126, P = 0.626), hip OA (IVW, OR 0.990, 95% CI: 0.941–1.042, P = 0.704), knee or hip OA (IVW, OR 1.005, 95% CI: 0.915–1.105, P = 0.911), and OA from UK Biobank (IVW, OR 0.796, 95% CI: 0.233–2.714, P = 0.715). Importantly, these findings remained consistent across different genders and in reverse MR. Conclusions Our study found that OA patients had a higher risk of hypertension only among males in the observational study. However, MR analysis did not uncover any causal relationship between OA and hypertension.

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Osteoarthritis and hypertension: observational and Mendelian randomization analyses

Yang,

Liu,

Liu

et al. 2024

Arthritis Res Ther

View full text Add to dashboard Cite

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Systemic Inflammation and Endothelial Dysfunction—a Possible Link Between Osteoarthritis and Hypertension: Comment on the Article by Niu et al

Cited by 1 publication

References 7 publications

Osteoarthritis and hypertension: observational and Mendelian randomization analyses

Osteoarthritis and hypertension: observational and Mendelian randomization analyses

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