Systemic Infections in Heroin Addicts

Beckett, H. Dale

doi:10.1016/s0140-6736(68)90041-x

Cited by 1 publication

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NK cell function, this effect by opioids being first reported in opioid abusers. 2 More recent studies have demonstrated that intravenous morphine reduces both NK cell activity and antibody-dependent cellular cytotoxicity (ADCC) in human volunteers. 4 Acute or chronic morphine treatment administered by subcutaneous injection has also been reported to suppress splenic NK cell activity in rats.…”

Section: Intrathecal Morphine Suppresses Immune Functionmentioning

confidence: 99%

Intrathecal Morphine Suppresses Immune Function in Rats with Inflammatory-induced Pain

et al. 2007

View full text Add to dashboard Cite

Acute and chronic systemic administration of morphine is known to suppress immune function; however, the effect of chronic intrathecal (IT) morphine on immune function in inflammatory-induced pain is still unclear. This study examined the effects on the immune system of IT morphine in rats with formalin-induced pain. Lumbar IT catheters were implanted in rats and saline or 2.5, 5.0 or 10.0 microg/h morphine were administered for 7 days. On the last day, formalin-induced inflammatory pain was induced in rat hind paws and pain intensity was assessed. Rat spleens were then harvested for immune function assay. The IT morphine induced a dose-dependent analgesic effect and lactic acid dehydrogenase release assay showed dose-dependent suppression of natural killer cell activity. Concanavalin-A-induced splenocyte proliferation assay showed IT morphine to suppress T lymphocyte function in a dose-dependent manner. Flow cytometry showed IT morphine significantly to decrease T lymphocyte function and the percentages of T lymphocyte subsets in a dose-dependent manner. Hence, in inflammatory-induced pain IT morphine was found to suppress immune function. Chronic IT morphine should be used cautiously to treat chronic pain in immunocompromised cases.

show abstract

Section: Intrathecal Morphine Suppresses Immune Functionmentioning

confidence: 99%