Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy

Kikuchi, Akio; Takeda, Atsushi; Oda, Hiroshi; Kimpara, Teiko; Hisanaga, Kinya; Sato, Nobuyuki; Nunomura, Akihiko; Castellani, Rudy J.; Perry, George; Smith, Mark A.; Itoyama, Yasuto

doi:10.1006/nbdi.2002.0466

Cited by 268 publications

(176 citation statements)

References 24 publications

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“…Indeed, RNA is subjected to more oxidative damage than DNA in humans [77]. 7, 8-dihydro-8-oxoguanosine (8-oxoG) is the most extensively studied RNA damage product and its levels are raised in various pathological conditions like Alzheimer's disease [78], Parkinson's disease [79], atherosclerosis [80], hemochromastosis [81] and myopathies [82].…”

Section: Ribonucleic Acid (Rna)mentioning

confidence: 99%

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

2014

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Free radicals and other oxidants have gained importance in the field of biology due to their central role in various physiological conditions as well as their implication in a diverse range of diseases. The free radicals, both the reactive oxygen species (ROS) and reactive nitrogen species (RNS), are derived from both endogenous sources (mitochondria, peroxisomes, endoplasmic reticulum, phagocytic cells etc.) and exogenous sources (pollution, alcohol, tobacco smoke, heavy metals, transition metals,

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Section: Ribonucleic Acid (Rna)mentioning

confidence: 99%

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

2014

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“…In PD brain, similar 8-hydroxyguanosine immunoreactivity in cytoplasmic RNA is seen in the substantia nigra, and to a lesser extent in neurons of the nucleus raphe dorsalis and oculomotor nucleus, and occasionally in glia [18]. 8-hydroxy-2'-deoxyguanosine and 8-hydroxyguanosine have also been found to be elevated in the serum and cerebrospinal fluid of patients with PD [19].…”

Section: Iron and Oxidative Stress In Parkinson's Diseasementioning

confidence: 81%

Oxidative Stress in Parkinson`s Disease

Friedlich

Smith²,

Zhu³

et al. 2009

TOPATJ

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Abstract:Parkinson's disease (PD) is a progressive, age-related movement disorder, whose neuropathology is characterized by degeneration of the afferent pigmented neurons of the substantia nigra. Also associated with PD neuropathology are disrupted iron homeostasis, oxidative stress, and intracellular deposition of alpha-synuclein protein in Lewy bodies. Here we review oxidative stress mechanisms in Parkinson's disease, with emphasis on the relationship between oxidative stress and alpha-synuclein gene expression.

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“…One biomarker of interest is 8-hydroxydeoxyguanosine (8-OHdG), which is an indicator of oxidative stress, impaired metabolism, and mitochondrial dysfunction (Kikuchi et al 2002). 8-OHdG is a compound formed through hydroxylation of the guanine base by radical oxygen species.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of cytotoxic, membrane and DNA damaging effects of Origanum majorana’s essential oil and its oxygenated monoterpene component linalool on parental and epirubicin-resistant H1299 cells

Erdoğan

Özkan

2013

Biologia

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In this study, cytotoxic, membrane and DNA damaging effects of the essential oil from Origanum majorana and its oxygenated monoterpene component linalool were tested on parental and epirubicin-resistant (drug-resistant) human lung cancer cell lines (H1299). Essential oil's and linalool's cytotoxicities were examined and parental cells were found more sensitive to the essential oil's and linalool's cytotoxicities than drug-resistant cells. O. majorana essential oil had more effective membrane damaging effect than linalool on parental cells, while in drug-resistant H1299 cells, linalool had more effective membrane damaging effect than the essential oil. O. majorana essential oil possessed more effective DNA damaging effect than linalool on both parental and drug-resistant cells. The conclusions from this study suggest that O. majorana essential oil and linalool exhibit cytotoxic, membrane and DNA damaging effects. They thus need further investigation as potential therapeutic agents for human lung cancer.

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Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy

Cited by 268 publications

References 24 publications

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

Oxidative Stress in Parkinson`s Disease

A comparative study of cytotoxic, membrane and DNA damaging effects of Origanum majorana’s essential oil and its oxygenated monoterpene component linalool on parental and epirubicin-resistant H1299 cells

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