Systemic immune response in squamous cell carcinoma of the head and neck: a comparative concordance index analysis

Tham, Tristan; Wotman, Michael; Chung, Christopher; Ahn, Seungjun; Dupuis, Holly; Gliagias, Vasiliki; Movsesova, Tamara; Kraus, Dennis H.; Costantino, Peter D.

doi:10.1007/s00405-019-05554-x

Cited by 17 publications

(14 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is believed that lymphoid lineage preponderance of white blood cell was related to better survival based on previous HNSCC study (Wu et al, 2017). Several studies found that lower LMR predicted reduced DSS and OS in HNSCC (Table 7) (Takahashi et al, 2019;Tham et al, 2019;Furukawa et al, 2019;Yang et al, 2018; Kano et al, 2017). In addition, the relationship between LMR and advanced stage OPSCC was not thoroughly evaluated.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of pretreatment prognostic nutritional index and lymphocyte-to-monocyte ratio in patients with advanced p16-negative oropharyngeal cancer—a retrospective study

Tsai

Huang

Chuang

et al. 2020

PeerJ

View full text Add to dashboard Cite

Background Systemic inflammation and nutritional status both play roles in the survival of cancer patients. Therefore, it is important to understand the effects of prognostic nutritional index (PNI) and lymphocyte-to-monocyte ratio (LMR) on the survival of patients with advanced p16-negative oropharyngeal cancer. Methods A total of 142 patients diagnosed with advanced p16-negative oropharyngeal cancer between 2008 and 2015 were enrolled in this study. All patients received primary treatment with definite concurrent chemoradiotherapy (CCRT). Optimal cutoff values for PNI and LMR were determined using receiver operating characteristic curves for survival prediction. Survival rates for different level of PNI and LMR were estimated and compared using Kaplan–Meier method and log-rank test to see if there were significant effects on these end points, including 5-year overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS) rates. The effects of PNI and LMR on survival were assessed using Cox regression model adjusted for other prognostic factors. Results The results showed the optimal cutoff values for PNI and LMR were 50.5 and 4.45, respectively. A high PNI (≧50.5) was significantly improved the 5-year OS. A low LMR (<4.45) was significantly associated with a poor 5-year DFS, DSS, and OS. In multivariate analysis, both PNI and LMR were independent prognosticators for 5-year OS. Conclusions Elevated pretreatment PNI and LMR are both favorable prognosticators in advanced p16-negative oropharyngeal cancer patients undergoing CCRT.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical significance of pretreatment prognostic nutritional index and lymphocyte-to-monocyte ratio in patients with advanced p16-negative oropharyngeal cancer—a retrospective study

Tsai

Huang

Chuang

et al. 2020

PeerJ

View full text Add to dashboard Cite

show abstract

“…Increasing evidence has shown that peripheral blood cells and relevant ratios are related to the inflammation as well as AKI after cardiovascular surgery, such as platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) (12,13). Lymphocyte-to-monocyte ratio (LMR), calculated from the lymphocyte and monocyte counts of peripheral blood, has gained increasing attention for its independent prognostic value of clinical outcomes in multiple malignant cancers (14)(15)(16)(17)(18). A lower LMR seems to be associated with increased systemic inflammation and decreased survival in malignancies (19).…”

Section: Introductionmentioning

confidence: 99%

The Predictive Role of Lymphocyte-to-Monocyte Ratio in Acute Kidney Injury in Acute Debakey Type I Aortic Dissection

Chen

Yun

et al. 2021

Front. Surg.

View full text Add to dashboard Cite

Background: The post-operative acute kidney injury (AKI) represents a common complication in the Acute Debakey Type I Aortic Dissection (ADTIAD) and predicts a poorer prognosis. The clinical evidence is scarce supporting the predictive value of the pre-operative lymphocyte-to-monocyte ratio (LMR) in post-operative AKI in ADTIAD.Methods: In this retrospective cohort study, 190 consecutive patients with ADTIAD enrolled for surgical treatment between January 1, 2013, and December 31, 2018. The diagnosis of AKI followed the Kidney Disease: Improving Global Outcomes guidelines (KDIGO). Pre-operative LMR and other possible risk factors were analyzed for their prognostic value in the post-operative AKI in ADTIAD.Results: The subjects were assigned to the low-LMR and high-LMR groups according to the median value of pre-operative LMR. For post-operative AKI, the incidence and the severity in the low-LMR group were statistically different from that of the high-LMR group. Besides, the lower LMR was statistically associated with the more extended ICU stay and intubation time and higher incidences of ischemic stroke and in-hospital mortality. Additionally, in the multivariable analysis, the pre-operative LMR was an independent predictor for post-operative AKI in ADTIAD. A predictive model for post-operative AKI in ADTIAD was established incorporating LMR.Conclusions: LMR is an independent prognostic indicator incorporated into the predictive model with other risk factors to predict the post-operative AKI in ADTIAD.

show abstract

“…9 In a meta-analysis of head and neck cancers by Tham et al NLR, LMO, and TLO were found to be associated with disease-free survival but not associated with mean survival. 12 In a meta-analysis conducted by Takenaka et al high platelet level and TLO were found to be associated with poor prognosis in head and neck cancers. 13 In our study, no significant differences were found in patients with NLR, MLO, BLO, and TLO nasal polyps, antrochoanal polyps, and inverted papilloma.…”

Section: Discussionmentioning

confidence: 97%

Evaluation of peripheral blood cell levels in nasal polyposis, anthrochoanal polip and inverted papillom patients

Birinci

Terzi

Çeliker

et al. 2021

Int J Otorhinolaryngol Head Neck Surg

View full text Add to dashboard Cite

Background: Nasal polyps, antrochoanal polyps and Inverted papilloma are nasal masses. The aim of this study the levels and rates of peripheral blood cells are examined in patients with nasal polyps, antrochoanal polyps, and inverted papilloma, and it is investigated whether peripheral blood elements can be used as a marker in the differential diagnosis of these three pathologiesMethods: The files of 70 patients were retrospectively analyzed between January 2015 and December 2018. Patient were divided into three groups as inverted papilloma, nasal polyposis and antrochoanal polyp. Neutrophil, lymphocyte, eosinophil, monocyte and platelet counts, NLR, ELO, MLO, BLO and TLO values of each of these three groups were compared statistically separately.Results: A total of 70 patients, including 24 nasal polyps, 26 antrochoanal polyps, and 20 inverted papillomas, were included in the study. There was no statistical difference between the groups in terms of NLR, BLO, MLO, TLO (p=0.479). Only ELO value was higher in the nasal polyp group (p=0.035).Conclusions: As in many areas, easier and cheaper diagnostic methods and markers are needed in nasal cavity masses. In our study, we found no evidence that peripheral blood cells could be used to guide the diagnosis and treatment plan of the most common mass lesions of the nasal cavity. Broader and more comprehensive studies are needed for definitive results.

show abstract

Systemic immune response in squamous cell carcinoma of the head and neck: a comparative concordance index analysis

Cited by 17 publications

References 32 publications

Clinical significance of pretreatment prognostic nutritional index and lymphocyte-to-monocyte ratio in patients with advanced p16-negative oropharyngeal cancer—a retrospective study

Clinical significance of pretreatment prognostic nutritional index and lymphocyte-to-monocyte ratio in patients with advanced p16-negative oropharyngeal cancer—a retrospective study

The Predictive Role of Lymphocyte-to-Monocyte Ratio in Acute Kidney Injury in Acute Debakey Type I Aortic Dissection

Evaluation of peripheral blood cell levels in nasal polyposis, anthrochoanal polip and inverted papillom patients

Contact Info

Product

Resources

About