Systemic immune-inflammation index as a promising predictor of mortality in patients with acute coronary syndrome: a real-world study

Su, Gaofan; Zhang, Ying; Xiao, Ruyi; Zhang, Tingting; Gong, Baoan

doi:10.1177/03000605211016274

Cited by 23 publications

(17 citation statements)

References 34 publications

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“…(9)(10)(11)(12) In a study conducted in patients with the acute coronary syndrome, they investigated the comorbidities of the patients using the Elixhauser Comorbidity Index and it was found that the SII value was higher in patients with comorbidity. (13) To the best of our knowledge, the usefulness of the SII was evaluated for the first time for upper GI bleeding in the present study; however, it was not a useful parameter in predicting the Forrest classification as well as in determining the likelihood of bleeding present during esophagoduednoendoscopy.…”

Section: Discussionmentioning

confidence: 69%

Relationship of the CRP/albumin ratio and the systemic immune-inflammation index with Forrest classification in patients with gastrointestinal bleeding

Bozan¹,

Atiş

2022

Journal of Health Sciences and Medicine

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Aim:The present study aimed to investigate CRP/albumin ratio and the systemic immune-inflammation index (SII) and Forrest classification in patients who presented to the emergency department with acute upper gastrointestinal (GI) bleeding. Materials and Method: Patients over 18 years of age who presented to the emergency department of our hospital with melena, hematemesis, and hematochezia and were diagnosed with upper GI bleeding via esophagoduodenoscopy were included in the study. Esophagoduodenoscopy results, and accordingly, the Forrest classifications, together with complete blood count, including hemoglobin, platelet, and neutrophil values, as well as demographic characteristics were recorded. SII (calculated by multiplying the platelet count with neutrophil count and dividing the value obtained by the lymphocyte count [platelet (P)×neutrophil (N)/lymphocyte (L)]) and CRP/albumin ratio was calculated. Results: No statistically significant difference was observed among the Forrest classification groups in terms of the median SII values as well as median CRP/albumin ratios. However, a statistically significant difference in median CRP/albumin ratios was observed among the dichotomized Forrest classification groups. Conclusion:The SII is not a reliable parameter either predicts GI bleeding or the Forrest classification in patients with upper GI bleeding. The CRP/albumin ratio might be a poor predictor of bleeding; however, it can not predict the Forrest classification.

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Section: Discussionmentioning

confidence: 69%

Relationship of the CRP/albumin ratio and the systemic immune-inflammation index with Forrest classification in patients with gastrointestinal bleeding

Bozan¹,

Atiş

2022

Journal of Health Sciences and Medicine

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“…10,11 On the other hand, several studies have reported the prognostic value of high SII for acute coronary artery disease and type B aortic dissection. [12][13][14] And our study further related preoperative systemic inflammation with prognosis of ATAD underwent surgery. The results showed that SII is an independent biomarker of short-term outcomes in patients with ATAD surgery.…”

Section: Discussionmentioning

confidence: 72%

Systemic immune‐inflammation index predicted short‐term outcomes in ATAD patients undergoing surgery

Yang

Wang

et al. 2022

Journal of Cardiac Surgery

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Objective: Systemic immune-inflammation index (SII) is a biomarker that reflect systemic inflammation. We aimed to assess the value of SII in prediction of shortterm outcomes in acute type A aortic dissection (ATAD) patients undergoing surgery.Method: All patients underwent surgery for ATAD at our institution from 2018 to 2020 (n = 324) were retrospectively reviewed and divided into low SII (<1582.6 × 10 9 /L) and high SII (≥1582.6 × 10 9 /L) group according to optimal cutoff values defined by receiver operating characteristic curve. Cox regression and Kaplan-Meier analyses were performed to illustrate the correlation between SII and postoperative short-outcomes, including 30-day mortality and main complications after surgery.Results: In total, 48 (14.8%) patients died in 30 days after ATAD surgery. And multivariable Cox analysis demonstrated that high preoperative SII was closely related with 30-day mortality (hazard ratio: 3.532, 95% confidence interval:1.719-7.255, p = .001). Furthermore, Kaplan-Meier analysis illustrated that the short-term mortality rate increased significantly in high SII group (p < .001). In addition, the incidence of main postoperative complications including major adverse cardiovascular events (p = .001) and multiorgan failure (p = .002) were higher in high SII group. However, the length of intensive unit stay (p = .909) and hospital stay (p = .836) presented no difference in two groups. Conclusion:The study indicated that SII was an available biomarker to predict postoperative short-term prognosis, but not length of stay in intensive care unit and hospital in ATAD patients. And SII may be applied to risk stratification and patient selection in ATAD patients before surgery.

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“…The SII is an indicator composed of platelet, neutrophil, and lymphocyte counts, whose formula is: platelet counts × neutrophil counts/lymphocyte counts. It has shown possible prognostic prediction abilities in malignant tumors, coronary artery disease, and acute IS [ 56 , 57 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

Acute Inflammation in Cerebrovascular Disease: A Critical Reappraisal with Focus on Human Studies

Dias

Azevedo

et al. 2021

Life

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Recent attention has been focused on the field of inflammatory biomarkers associated with vascular disorders, regarding diagnosis, prognosis, and possible therapeutical targets. In this study, we aimed to perform a comprehensive review of the literature regarding the use of inflammatory biomarkers in stroke patients. We searched studies that evaluated inflammation biomarkers associated with Cerebrovascular Disease (CVD), namely, ischemic Stroke (IS), Intracerebral Hemorrhage (ICH) and Cerebral Venous Thrombosis (CVT). As of today, neutrophil–lymphocyte ratio (NLR) seems the be the most widely studied and accepted biomarker for cerebrovascular disease due to its easy access and availability. Although demonstrated as a prognostic risk factor, in IS, ICH and CVT, its diagnostic role is still under investigation. Several other prognostic factors could be used or even combined together into a diagnostic or prognostic index. Multiple inflammatory biomarkers appear to be involved in IS, ICH, and CVT. Blood inflammatory cells, easily measured and accessible at admission may provide information regarding accurate diagnosis and prognosis. Although not yet a reality, increasing evidence exists to suggest that these may become potential therapeutic targets, likely influencing or mitigating complications of CVD and improving prognosis. Nevertheless, further larger, well-designed randomized clinical trials are still needed to follow up this hypothesis.

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Systemic immune-inflammation index as a promising predictor of mortality in patients with acute coronary syndrome: a real-world study

Cited by 23 publications

References 34 publications

Relationship of the CRP/albumin ratio and the systemic immune-inflammation index with Forrest classification in patients with gastrointestinal bleeding

Relationship of the CRP/albumin ratio and the systemic immune-inflammation index with Forrest classification in patients with gastrointestinal bleeding

Systemic immune‐inflammation index predicted short‐term outcomes in ATAD patients undergoing surgery

Acute Inflammation in Cerebrovascular Disease: A Critical Reappraisal with Focus on Human Studies

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