Systemic immune-inflammation index as a prognostic marker for distal cholangiocarcinoma

Terasaki, Fumihiro; Sugiura, Teiichi; Okamura, Yukiyasu; Ito, Takaaki; Yamamoto, Yusuke; Ashida, Ryo; Ohgi, Katsuhisa; Uesaka, Katsuhiko

doi:10.1007/s00595-021-02312-7

Cited by 17 publications

(24 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All studies reported OS, but only two studies reported RFS ( 21 , 22 ), and one study reported CSS ( 20 ). Three studies were conducted in China ( 21 , 22 , 24 ), one in America ( 20 ), and one in Japan ( 23 ). The cutoff values were not uniform and ranged from 412.6 to 1450.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic Significance of the Systemic Immune-Inflammation Index in Patients With Cholangiocarcinoma: A Meta-Analysis

et al. 2022

View full text Add to dashboard Cite

BackgroundThe systemic immune-inflammation index (SII) is a significant prognostic factor for neoplastic diseases. However, the prognostic value of SII in patients with cholangiocarcinoma (CCA) remains unclear. This meta-analysis aimed to investigate the prognostic value of preoperative SII in patients with CCA.MethodWe systematically searched for relevant studies in PubMed, Scopus, EMBASE, Web of Science, PROSPERO, and Cochrane Library databases up to March 22, 2022. Hazard ratios (HRs) and 95% confidence intervals (CIs) were used to estimate the association between SII and survival outcomes, including overall survival (OS) and recurrence-free survival.ResultsFive studies with 1402 patients were included in this meta-analysis to determine the prognostic value of preoperative SII. The results showed that a higher SII was associated with poor OS in patients with CCA who underwent invasive surgery (HR=1.916; 95% CI, 1.566–2.343; Z=6.329; P<0.001). The results were reliable in the subgroup analysis according to country, age, sample size, SII cutoff values, and treatment methods.ConclusionsA high preoperative SII appears to be an effective and practical method for monitoring survival in patients with CCA.Systematic Review RegistrationInternational Platform of Registered Systematic. Review and Meta-Analysis Protocols (INPLASY), identifier INPLASY202240015.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Some studies were excluded for the following reasons: not presenting usable data; nonoperative; and not excluding gallbladder or ampullary neoplasm. Finally, five studies were included in this meta-analysis (20)(21)(22)(23)(24) .…”

Section: Resultsmentioning

confidence: 99%

Prognostic Significance of the Systemic Immune-Inflammation Index in Patients With Cholangiocarcinoma: A Meta-Analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The median sample size was 140 patients. Five studies included patients with ICC [ 18 , 24 , 26 , 27 , 31 ], three studies enrolled patients with ECC [ 17 , 32 , 33 ], three studies recruited patients with GBC [ 25 , 28 , 30 ], and two studies included patients with BTC [ 16 , 29 ]. All included studies reported the prognostic value of the SII for OS in BTC, five studies reported the association between the SII and RFS [ 24 , 26 , 27 , 31 , 33 ], and one study showed a correlation between the SII and PFS [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

“…Subsequently, two studies were eliminated because one study did not provide survival data and the other included overlapping patients. Finally, 13 studies with 3515 patients [16][17][18][24][25][26][27][28][29][30][31][32][33] were included in this meta-analysis (Fig. 1).…”

Section: Literature Selectionmentioning

confidence: 99%

“…Previous studies have shown that an elevated SII is associated with poor prognosis in non-small cell lung cancer (SCLC) [20], colorectal cancer [21], breast cancer [22], and renal cell carcinoma [23]. Many studies have also investigated the prognostic significance of the SII in BTC; however, the results were inconsistent [16][17][18][24][25][26][27][28][29][30][31][32][33]. Some studies identified the SII as a significant prognostic factor for BTC [27][28][29], whereas others reported that this association was nonsignificant [16,33].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic role of the systemic immune-inflammation index in biliary tract cancers: a meta-analysis of 3,515 patients

Zhang

Yao²

2022

World J Surg Onc

View full text Add to dashboard Cite

Background The systemic immune-inflammation index (SII) is an inflammatory parameter calculated as platelet count × neutrophil count/lymphocyte count in the peripheral blood. In recent years, the prognostic role of the SII in patients with biliary tract cancer (BTC) has been gradually investigated. However, the results were controversial. This meta-analysis aimed to illustrate the prognostic value of the SII in BTC. Methods The electronic databases of PubMed, the Web of Science, Embase, and the Cochrane Library were thoroughly retrieved up to April 15, 2022. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were used to evaluate the prognostic value of the SII for clinical outcomes. The association between the SII and overall survival (OS) and recurrence-free survival (RFS)/progression-free survival (PFS) was evaluated. Results Thirteen studies involving 3515 patients were included in this meta-analysis. The pooled results indicated that an elevated SII was significantly associated with poor OS (HR, 1.77; 95% CI, 1.47–2.14; p<0.001) and RFS/PFS (HR, 1.66; 95% CI, 1.38–1.99; p<0.001) in patients with BTC. Subgroup analysis stratified by country, sample size, and cutoff value showed similar results. The sensitivity analysis and publication bias test confirmed the reliability of our results. Conclusions An elevated pretreatment SII was significantly associated with worse OS and RFS/PFS in patients with BTC. Our results suggest that the SII is a valuable and cost-effective prognostic parameter for the treatment of patients with BTC.

show abstract

Long‐term Survival After Resection of Periampullary Cancer

2023

View full text Add to dashboard Cite

Systemic immune-inflammation index as a prognostic marker for distal cholangiocarcinoma

Cited by 17 publications

References 30 publications

Prognostic Significance of the Systemic Immune-Inflammation Index in Patients With Cholangiocarcinoma: A Meta-Analysis

Prognostic Significance of the Systemic Immune-Inflammation Index in Patients With Cholangiocarcinoma: A Meta-Analysis

Prognostic role of the systemic immune-inflammation index in biliary tract cancers: a meta-analysis of 3,515 patients

Long‐term Survival After Resection of Periampullary Cancer

Contact Info

Product

Resources

About