Systemic Hypertension and Mitral Valve Disease

Obeyesekere, H. I.; Dulake, Michelle; Demerdash, Hala Mourad; Hollister, Robert M.

doi:10.1136/bmj.2.5459.441

Cited by 10 publications

(4 citation statements)

References 10 publications

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“…Gray (1954) and Roseman and Wasserman (1951) found that the incidence of hypertension was not significantly greater in patients with mitral stenosis than in control groups. These findings were not in accord with those of Obeyesekere et al (1965) who found that more than half their patients with mitral valve disease had a systemic blood pressure above normal.…”

contrasting

confidence: 94%

Proceedings of The British Cardiac Society

1967

Heart

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contrasting

confidence: 94%

Proceedings of The British Cardiac Society

1967

Heart

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“…In the present study, arterial hypertension was found to be significantly correlated with MS and TR. A literature review revealed a higher incidence of systemic hypertension in patients with MS [ 25 ] but provided no explanation for it; the etiology could be the subject of a future prospective study aimed at investigating a possible causal relationship. Indeed, blood pressure elevation recently has been investigated as a risk factor for development of AS or AR [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Mitral and Aortic Valvular Disease and Left Ventricular Dysfunction in a Lebanese Population: Retrospective Single-Center Experience

et al. 2020

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Background Recently, new therapeutic approaches have revolutionized the management of left ventricular dysfunction (LVD) and valvular heart disease (VHD), which are a growing public health problem. In parallel, there are no available epidemiological data about LVD and VHD in developing countries, especially in the Mediterranean area. This retrospective study was conducted at a single center and aimed to evaluate the associations between mitral and aortic valvular disease and left ventricle systolic and diastolic dysfunction in the Lebanese population. Material/Methods A retrospective study was conducted of 4520 consecutive patients aged >18 years who were referred to the Cardiovascular Department of Notre Dame de Secours-University Hospital in Jbeil-Lebanon for transthoracic echocardiography between December 2016 and December 2019. The study population was divided into different groups based on types of LVD and VHD. Left ventricle systolic dysfunction was defined as a left ventricle ejection fraction (EF) ≤40%. Statistical analysis was carried out using SPSS software version 20. Results VHD and systolic dysfunction were more common in men, whereas diastolic dysfunction was more common in women. Being older than age 65 years and smoking were significantly associated with heart failure with preserved EF, whereas female sex was a significant preventive factor against heart failure with reduced EF. Systemic hypertension was correlated with mitral stenosis and tricuspid regurgitation, whereas diabetes mellitus was associated with tricuspid regurgitation (TR). Smoking and older age also appeared to be associated with aortic stenosis. Conclusions Mitral valve disease (regurgitation and stenosis) was significantly correlated with systolic dysfunction, whereas aortic and mitral regurgitation were associated with diastolic dysfunction. Better monitoring of cardiovascular disease risk factors may lead to a reduced burden of LVD and VHD.

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“…A further 12 derived considerable benefit from operation initially for a variable period of three to five years, but have since deteriorated and are now in a state of congestive cardiac failure with frank mitral incompetence. Three of these have systemic hypertension with renal damage, due in all probability to recurrent renal emboli (Obeyesekere et al, 1965). Fifty-eight, however, have maintained their improvement since operation, the period of follow-up being six months to nine years.…”

Section: Operative Datamentioning

confidence: 94%

“…Systemic hypertension was recorded in 14 pre-operatively, and evidence of renal damage (albuminuria with raised blood urea and creatinine) was noted in five of those. Repeated emboli lodging in the kidney are now known to be a potent cause of subsequent renal damage and hypertension in mitral-valve disease (Obeyesekere et al, 1965), and it is reasonable to assume that such was the case in these five. A further two patients, who pre-operatively had normal blood pressure and renal function, have since developed this syndrome, several years after valvotomy.…”

Section: Associated Conditionsmentioning

confidence: 99%